Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers

doi:10.21873/invivo.11198

Cited by 13 publications

(11 citation statements)

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“…Histiocytic sarcoma: Histiocytic sarcoma is a rare cancer type. However, in certain dog breeds, this cancer occurs at a high frequency, with studies reporting 20–25% of Bernese mountain dogs and flat-coated retrievers being affected by the disease [ 41 , 59 , 60 ]. Three GWASs have investigated genetic associations with histiocytic sarcoma development, either alone or in combination with other cancer types, in selected dog breeds.…”

Section: Identification Of Predisposing Risk Factors For Sarcoma Deve...mentioning

confidence: 99%

Sarcoma Predisposition in Dogs with a Comparative View to Human Orthologous Disease

Arendt

Dobson

2023

Veterinary Sciences

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Sarcomas are malignant tumors arising from the embryonic mesodermal cell lineage. This group of cancers covers a heterogenous set of solid tumors arising from soft tissues or bone. Many features such as histology, biological behavior and molecular characteristics are shared between sarcomas in humans and dogs, suggesting that human sarcoma research can be informative for canine disease, and that dogs with sarcomas can serve as relevant translational cancer models, to aid in the understanding of human disease and cancer biology. In the present paper, risk factors for the development of sarcoma in dogs are reviewed, with a particular focus on recent advances in clinical genetics, and on the identification of simple and complex genetic risk factors with a comparison with what has been found in human orthologous disease.

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Section: Identification Of Predisposing Risk Factors For Sarcoma Deve...mentioning

confidence: 99%

Sarcoma Predisposition in Dogs with a Comparative View to Human Orthologous Disease

Arendt

Dobson

2023

Veterinary Sciences

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“…A number of studies have evidenced breed-related predispositions to specific tumour types, including skin neoplasia (6). For instance, an increased risk of malignant histiocytosis has been reported in the Bernese Mountain Dog, anal sac gland carcinoma in the English cocker spaniel, or malignant melanomas in the Schnauzer (6, 9, 10, 26). The highest risk for MCTs has been noted in Boxers (18, 33).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds

Śmiech

Łopuszyński

Ślaska

et al. 2019

Journal of Veterinary Research

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Introduction: Breed predisposition to cutaneous mast cell tumours (MCT) in a population of dogs in Poland affected by various skin tumours was assessed, and the distribution of MCT characteristics such as histological grading, sex, age, and location, in predisposed breeds was evaluated. Material and Methods: The retrospective epidemiological study included 550 dogs affected by cutaneous MCTs with a reference group of 2,557 dogs diagnosed with other skin tumours. Results: A univariable logistic regression analysis was performed to determine the odds ratios (ORs) with 95% confidence intervals. The risk of high-grade MCTs was the highest for Shar-Peis (OR: 26.394) and American Staffordshire Terriers (OR: 2.897). Boxers (OR: 6.619), Labrador Retrievers (OR: 2.630), French Bulldogs (OR: 2.050), Golden Retrievers (OR: 1.949), and American Staffordshire Terriers (OR: 2.592) were mainly affected by low-grade MCTs. The high risk of MCT was calculated to be at the age of 4–6 years for Labrador Retrievers (OR: 2.686) and 7–10 years for Boxers (OR: 2.956) and French Bulldogs (OR: 9.429). MCTs were significantly more often located on the trunk in French Bulldogs (OR: 4.680), American Staffordshire Terriers (OR: 2.520), and Labrador Retrievers (OR: 1.948). There was no statistically significant correlation between gender and the occurrence of MCTs in the breeds. Conclusions: The breed-predicated differences in the clinical course of MCTs suggest a genetic background for the tumours.

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“…Two weeks postoperatively, further staging was performed identifying metastatic histiocytic sarcoma within the spleen and cranial abdominal lymph nodes. In the canine, histiocytic sarcomas are one of the most aggressive and incurable tumors diagnosed [ 16 ]. Surgical intervention of histiocytic sarcomas alone may be adequate if metastasis is not detected at the time of diagnosis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Lymph Node Abscessation Secondary to Neoplasia in Two Dogs

Lumbrezer-Johnson

Hostnik

et al. 2022

Case Reports in Veterinary Medicine

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A 5-year-old male neutered mixed breed dog and an 8-year-old female spayed golden retriever presented for cervical swelling which was later diagnosed as abscessation of the retropharyngeal lymph node with a malignant round cell tumor and carcinoma with multifocal squamous differentiation, respectively. In veterinary medicine, there is limited published information regarding abscessation of lymph nodes secondary to a neoplastic process. While more common in humans, there are only limited case reports available. Advanced imaging (computed tomography), cytology, surgical excision, and histopathology lead to the final diagnosis. Both dogs underwent surgical extirpation of the lymph nodes and adjuvant chemotherapy protocols. Six weeks postsurgical excision, dog one was euthanized due to quality-of-life concerns. The second dog successfully completed 18 treatments of radiation therapy and was still alive at 388 days postsurgical excision. At the time of manuscript submission, the second dog was doing well clinically.

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Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers

Abstract: Abstract. Background

Cited by 13 publications

References 54 publications

Sarcoma Predisposition in Dogs with a Comparative View to Human Orthologous Disease

Sarcoma Predisposition in Dogs with a Comparative View to Human Orthologous Disease

Occurrence and distribution of canine cutaneous mast cell tumour characteristics among predisposed breeds

Lymph Node Abscessation Secondary to Neoplasia in Two Dogs

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