Morphological definition of CD71 positive reticulocytes by various staining techniques and electron microscopy compared to reticulocytes detected by an automated hematology analyzer

Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes

“…Indeed, the CD71 2 maturing reticulocytes are predominantly found in the peripheral circulation, whereas the CD71 1 immature reticulocytes are largely confined to the bone marrow. 5,9,[12][13][14][15]28,35 This raises the possibility that the bulk of P vivax invasion occurs in the bone marrow and not in the blood.…”

“…8 Notably, 1 such receptor, the transferrin receptor (CD71), is sequentially lost and becomes completely absent by the time the normocyte is formed, [9][10][11] thus making it a useful biomarker for the fine-scale age-grading of reticulocytes. 5,12,13 Most crucially, CD71 is depleted ;20 hours before the last remnants of reticular matter (commonly detected by new methylene blue [NMB] There is an Inside Blood Commentary on this article in this issue.…”

Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study

“…The transferrin receptor (or CD71) is usually expressed in immature erythroid precursors, 28 and such cells are usually very rare in peripheral blood. Preclinical in-vivo studies show that primitive prostate-cancer clonogenic cells compete for haemopoietic stem cell niches in bone marrow and displace haemopoietic stem cells into blood.…”

Fluorescent dye-based simple staining for in vivo micronucleus test with flow cytometer

“…CD71 is a transferrin receptor specific for erythroid precursors and erythrocytes in the early maturation stage [25]. Expression of CD71 is decreased earlier than disappearing reticular structures in newly differentiated erythrocytes [26]. IE in the early stage that account for 30-50% of RNA-positive reticulocytes are recognized as CD71-positive cells [4].…”