Morphological correlates to cognitive dysfunction in schizophrenia as studied with Bayesian regression

Abstract

Background: Relationships between cognitive deficits and brain morphological changes observed in schizophrenia are alternately explained by less gray matter in the brain cerebral cortex, by alterations in neural circuitry involving the basal ganglia, and by alteration in cerebellar structures and related neural circuitry. This work explored a model encompassing all of these possibilities to identify the strongest morphological relationships to cognitive skill in schizophrenia.

Stability of personality traits over a five-year period in Swedish patients with schizophrenia spectrum disorder and non-psychotic individuals: a study using the Swedish universities scales of personality

“…Control subjects were recruited among students, hospital staff members or from a population register. All controls with the exception of those recruited from a population register had earlier attended in biological research at the Karolinska Institute [22,[30][31][32]. The controls consisted of non-psychotic individuals unrelated to the patients.…”

Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study

“…studies and in vivo brain imaging studies (Wolf et al, 2008;Kubicki et al, 2007;Whitford et al, 2007;Laywer et al, 2006;Bogerts et al, 1990a,b;Witthaus et al, 2008). However, the extent to which these findings are related to vulnerability for schizophrenia, as opposed to the disease progression, is less certain.…”

COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation

“…A worse CPT performance has been associated with smaller prefrontal volume in patients with schizophrenia, 134 but not in studies that included patients with any psychosis 8,135,136 or healthy individuals. 8,[134][135][136] Studies in patients with schizophrenia, their unaffected co-twins and healthy controls have found no association between CPT performance and hippocampal volume.…”

“…8,[134][135][136] Studies in patients with schizophrenia, their unaffected co-twins and healthy controls have found no association between CPT performance and hippocampal volume. 8,[134][135][136][137] These findings suggest that worse performance on the n-back task is associated with smaller prefrontal and medial temporal volumes and that worse CPT performance is associated with smaller prefrontal volume in patients with schizophrenia. Consistent with this evidence, a meta-analysis of fMRI studies reported that the dorsolateral prefrontal cortex and the anterior cingulate cortex were less activated during the n-back task in patients with schizophrenia.…”