Morphological characterization of the coronary arteries in African sheep (Ovis orientalis). Differential analysis with those of humans and other animal species

Gómez, Fabián A.; Cortés, Luz S.; Ballesteros, Luis Ernesto

doi:10.5603/fm.a2018.0054

Cited by 4 publications

(12 citation statements)

References 20 publications

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“…In literature (Vincenti et al, 2014) it is believed that owing to its anatomical features are similar to human heart, the sheep heart can set a model for the studies conducted in human medicine. Besides the importance of using sheep heart as an experimental model, there were macroanatomic and morphometric studies on coronary arteries and myocardial bridges of various sheep breeds (Teke et al, 2017;Aksoy et al, 2018;Gomez et al, 2018). However, no studies on coronary arteries and myocardial bridges were found in Tuj and Hemshin sheep.…”

Section: Introductionmentioning

confidence: 99%

Macroanatomical Investigation of Arteria Coronaria and Myocardial Bridges in Tuj and Hemshin Sheep

Gürbüz¹,

Aksoy

2019

IJAR

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In the study, it was aimed that the macroanatomic features of the coronary arteries and myocardial bridges were investigated in Tuj and Hemshin sheep. 10 hearts of male Tuj sheep and 10 hearts of male Hemshin sheep were used as the study material. It was applied the latex injection and corrosion cast techniques. It was observed that the hearts were vascularized by arteria (a.) coronaria dextra and a. coronaria sinistra. A. coronaria sinistra was dominant in 8 Tuj and 9 Hemshin sheep, a. coronaria dextra was dominant in 2 Tuj and 1 Hemshin sheep. The r. interventricularis subsinuosus was formed by ramus (r.) circumflexus sinister in 8 Tuj and 9 Hemshin sheep, by r. circumflexus dexter in 1 Tuj sheep, and by r. proximalis atrii dextri in 1 Tuj and 1 Hemshin sheep. There were myocardial bridges on the r. interventricularis paraconalis in all of the hearts. There was a statistical difference in the length of the myocardial bridges on the sulcus interventricularis paraconalis between the hearts of Tuj and Hemshin sheep (P less than 0.05).

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Section: Introductionmentioning

confidence: 99%

Macroanatomical Investigation of Arteria Coronaria and Myocardial Bridges in Tuj and Hemshin Sheep

Gürbüz¹,

Aksoy

2019

IJAR

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“…Consequently, their usage as animal models to mimic the human coronary system merits careful scrutiny before findings can be extrapolated. 38,39…”

Section: Ijmsmentioning

confidence: 99%

“…Given that bovine species exhibit the most coronary artery anomalies, their usage as an animal model in better understanding the various treatment IJMS options for Type-A ADs is hence not justified, given that these findings would not necessarily accurately represent what we might see within humans. 38,39 Between porcine and ovine species however, the coronary vasculature is similar to that of humans. However, as aforementioned, much more research has been performed on the coronary arterial supply of pigs, with little to no comparative research being performed on their ovine counterparts, and as such, the former takes current precedence when selecting an animal model for Type-A AD research.…”

Section: Suitability For Use As Animal Clinical Models In Type-a Aort...mentioning

confidence: 99%

Comparative review of large animal models for suitability of proximal aortic endovascular repair

2022

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Background The advent of TEVAR heralds a paradigm shift in treating descending aortopathies and is viewed as a potential option for ascending aortic dissection (AD) repair too. Currently, TEVAR’s usage for ascending aortopathies remains limited. Consequently, an urgent requirement exists to choose appropriate animal models to better contemporary understanding of endovascularly treating Type-A ADs. This review article provides a summary of current literature on this topic. Two broad sections are covered, including the macroscopic differences between adult swine, ovine and porcine species versus that of their human counterparts, as well as the valvular, aortic and coronary vasculature variances. Methods A narrative review was conducted to integrate current findings of anatomical differences in valvular and ascending aortic anatomy amongst the aforementioned species. An electronic search of PubMed and Ovid Medline databases from January 1965 to June 2020 was performed, limited to articles published in English. Results Whilst macroscopic anatomy remains grossly similar, differences in valvular leaflet shape are present, with swine and porcine models possessing anatomic characteristics that are comparable to their human counterparts. Research into inter-species ascending aortic anatomy has not been extensively performed, highlighting a literature gap. Conversely, multiple morphological studies have highlighted that swine coronary vasculature is closely resemblant to that of man. Conclusion Both swine and ovine species are suitable as appropriate animal models in examining the feasibility of endovascular stent-grafts for ascending ADs. However, given the similarities in coronary and aortic valve anatomy to their human analogues, porcine models are better suited for this purpose.

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“…( James, 1965 ; Kalpana, 2003 ; Ballesteros et al, 2011 ). In addition, there is a reference to the study of the coronary tree in other types of ruminants such as the European bison ( Kupczyńska et al , 2015 ; Barszcz et al , 2020 ), sheep ( Bertho and Gagnon, 1964 ; Besoluk and Tipirdamaz, 2001 ; Aksoy et al , 2009 ; Gómez et al , 2019 ) and goats ( Lipovetsky et al , 1983 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of coronary arteries morphometry and distribution in bovines with humans and other animal species

Torres,

Machado,

2023

Open Vet J

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Background: The left coronary artery in the bovines is more developed than the right. Aim: The objective of the study is to describe the bovine coronary system from a morphological point of view, including the morphometry and its distribution. Methods: Arciform suture with 2.0 silk was applied around the sinus orifice and coronary ostium and a number 14 catheter was installed, to perfuse semi-synthetic polyester resin, consisting of a mixture of 85% GP40L palatal with 15% styrene with red color mineral. Results: The average weight of 28 bovine hearts used in our study was 1.534.1 kg. The right coronary artery had a proximal caliber of 5 +/- 0.9 mm. The left coronary artery caliber and length were 9.4 +/- 1.2 mm and 18.3 +/- 4.8 mm, respectively. This artery was divided into two branches in 85.7% of the cases and trifurcated in 14.3%. The paraconal interventricular branch ended more frequently in the apex (46.4%), and its proximal caliber was 6.4 +/- 1.4 mm. The left circumflex branch ended in 82.1% in the subsinusal interventricular sulcus, and its proximal caliber was 5.9 +/- 1.2 mm. The proximal calibers of the paraconal interventricular branch and the left circumflex branch did not present statistically significant differences (p=0.137). The sinoatrial branch presented a dual origin (right and left coronary arteries) in 46.4% of the cases and a single origin from the left coronary artery in 53.6% of the samples. In the evaluated hearts, left coronary dominance was observed in most cases (96.4%). There presence of anastomosis between the branches of the coronary arteries was observed in 57.1% of cases. Conclusion: The presence of a myocardial bridge was found in six hearts (21.4%). In bovines, a high percentage of anastomosis was found, a protective factor in obstruction of the coronary arterial branches.

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Morphological characterization of the coronary arteries in African sheep (Ovis orientalis). Differential analysis with those of humans and other animal species

Abstract: Due to the similitude in the features of the coronary arteries between African sheep and humans, this animal model can be proposed for procedural and hemodynamic activities.

Cited by 4 publications

References 20 publications

Macroanatomical Investigation of Arteria Coronaria and Myocardial Bridges in Tuj and Hemshin Sheep

Macroanatomical Investigation of Arteria Coronaria and Myocardial Bridges in Tuj and Hemshin Sheep

Comparative review of large animal models for suitability of proximal aortic endovascular repair

Comparison of coronary arteries morphometry and distribution in bovines with humans and other animal species

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