Morphological characteristics of models of generalized experimental periodontitis. Treatment with acisol

Abstract

Recently, the alterative effect of stress on periodontium, which is associated with the disturbance of lipid peroxidation processes, is increasingly being considered. In this regard, in order to reduce the severity of clinical manifestations of periodontitis in the acute stage, it is advisable to use antioxidant and antihypoxic therapy. In an experimental study, a comparative analysis of inflammatory-destructive periodontal lesions was performed at different levels of stress, and the therapeutic effect of acyzole on the degree of regeneration of soft periodontal tissues under the given conditions was determined.

Study of the anti-inflammatory, analgesic, ulcerogenic and anti-ulcerogenic activity of N-isopropenylimidazole zinc complex derivative

“…This calls for the search for and development of novel compounds with potent anti-inflammatory properties that do not have adverse effects on the digestive system, in order to create new drugs with an appropriate mechanism of action. Numerous studies have demonstrated that the medications atmizole, hesperidin, hypoxene, petaprot, acizole and mexidol, combining antihypoxant and antioxidant properties, have anti-inflammatory effects and are also able to greatly increase the therapeutic efficacy of NSAIDs (Bobr et al 2010;Novikov et al 2010;Turgeneva et al 2011;Babaniyazova et al 2013;Novikov and Ilyukhin 2013;Pozhilova 2014;Maskurova et al 2018;Ivanova et al 2021).…”