Morphological Changes of Mesenchymal Stem Cells by Cyclic Stretch

Ghazanfari, Samaneh; Tafazzoli-Shadpour, Mohammad; Shokrgozar, Mohammad Ali; Amirizadeh, Naser; Rangraz, E Jafargholi

doi:10.1109/bmei.2008.366

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Mesenchymal stem cells, for example, have been shown to differentiate into intervalvular cells under specific cyclic stretching conditions. 39 Stretching, however, has to be maintained below a maximum level to prevent cell damage and death, 40 which highlights the importance of tuning the stress distribution carefully throughout the leaflet.…”

Section: Resultsmentioning

confidence: 99%

Bioinspired Heart Valve Prosthesis Made by Silicone Additive Manufacturing

Coulter

Schaffner

Faber

et al. 2019

Matter

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Here we present a multi-material additive manufacturing approach for fabricating personalized polymeric aortic heart valves and surrounding vasculature, derived from a patient's CT data. The valves feature geometries and fiber-reinforced leaflet architectures that resemble those of native valve tissue, along with materials that match the hardness and modulus of specific features. The designs are first simulated to predict the stresses and deformations in the valve, and subsequently the fabricated valves are tested in vitro to show excellent hydrodynamic properties.

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Section: Resultsmentioning

confidence: 99%

Bioinspired Heart Valve Prosthesis Made by Silicone Additive Manufacturing

Coulter

Schaffner

Faber

et al. 2019

Matter

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“…Matsune et al reported that the degree of dynamic morphological change of murine embryonic stem cells is proportional to the increase in the ratio of cellular population in subculture [3]. Ghazanfari et al studied morphological changes of mesenchymal stem cells by cyclic stretch [4]. Besides, qualitative analysis of cell morphological change as an aided diagnosis of clinical diagnosis has been of interest for a long time [5].…”

Section: Introductionmentioning

confidence: 99%

A Method of Quantitative Analysis for Dynamic Cellular Morphological Change

Liu

et al. 2009

2009 2nd International Conference on Biomedical Engineering and Informatics

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In recent years, with the advancement of microscopic imaging technique, cellular morphological analysis has become one of the most important branches of biomedical image processing field. Cell image analysis, an assisting method of clinical information acquisition, has played an important role in facilitating the appropriate diagnosis and treatment against some serious diseases such as cancer, leukemia and etc. Early studies of this field focuses on still image information and mainly concerns either cell counting or the morphological characteristics of cell image. Furthermore, much effort has been devoted to analyzing the morphological change of cell image qualitatively, while less attention has been paid to analyzing it quantitatively which in fact is more effective, objective and accurate. Under this very circumstances, our work concentrates on analyzing the cellular morphological change by means of quantitative measurement, and a new method-circumference radial difference (Rd c) is proposed. The basic idea is to measure the morphological change by estimating the radial differences from 360 different angles. Two sets of lymphocyte video database provided by the cooperation hospital are used to verify the proposed approach. Experimental results show that the proposed (Rd c) measurement can produce reasonably good agreement with subjective judgment by people.

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“…impact of integrin-mediated mechanical forces resulted in the upregulation of collagen 1, VEGF, and SRY-box transcription factor 9 expression in MSCs, respectively indicating osteogenesis, angiogenesis, and chondrogenesis [170]. Without addition of growth factors, MSCs differentiated to smooth muscle cells under application of uniaxial tensile stretching, with higher proliferation rate and reorientation in the stretching direction [171]. Uniaxial stretching was reported to upregulate smooth muscle markers, while equiaxial cyclic loading led to their downregulation [161].…”

Section: Tensile Forcementioning

confidence: 99%

Exploiting material softness to regulate mesenchymal stem cells secretome production for "cell-free" regenerative medicine

Yang¹

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Morphological Changes of Mesenchymal Stem Cells by Cyclic Stretch

Cited by 3 publications

References 23 publications

Bioinspired Heart Valve Prosthesis Made by Silicone Additive Manufacturing

Bioinspired Heart Valve Prosthesis Made by Silicone Additive Manufacturing

A Method of Quantitative Analysis for Dynamic Cellular Morphological Change

Exploiting material softness to regulate mesenchymal stem cells secretome production for "cell-free" regenerative medicine

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