Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

Shlivko, I. L.; Kamensky, Vladislav A.; Донченко, Е. В.; Агрба, П. Д.

doi:10.1111/srt.12095

Cited by 10 publications

(10 citation statements)

References 14 publications

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“…Non‐invasive study of skin morphology is of utmost importance to the understanding of the skin's changes in physiological and pathological conditions. Understanding different skin types and conditions, and monitoring changes created by the application of topical products, has become increasingly fundamental in providing scientific validation of product claims in cosmetic science 29–35 …”

Section: Discussionmentioning

confidence: 99%

“…The absence of any damage and alteration of tissue allows for the study of tissue dynamics and the effects of interventions on skin at different times and on cosmetically sensitive areas. Consequently, there has been an increasing use of these imaging modalities in the dermo‐cosmetic field and industry to study skin pathophysiology, to test skin care products and to test the effects of various therapies 29–35 …”

Section: Introductionmentioning

confidence: 99%

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A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

Ciardo

Pezzini

Guida

et al. 2021

Experimental Dermatology

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Non‐invasive reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) have been extended to the dermo‐cosmetic field, for skin pathophysiology understanding and therapeutics monitoring. However, standardized methodology and parameters to interpret structures and changes in these settings are still lacking. Present study aimed to propose a validated standard methodology and a list of defined parameters for objective non‐pathological skin assessments in the cosmetically sensitive cheekbone area of the face. OCT and RCM quantitative, semi‐quantitative and qualitative features were considered for assessments. Validation process included 50 sets of images divided into two age groups. Inter‐rater reliability was explored to assess the influence of the proposed methodology. Quantitative OCT parameters of “epidermal thickness,” “density and attenuation coefficients” and “vascular density” were considered and calculated. Severity scales were developed for semi‐quantitative OCT features of “disruption of collagen” and “vascular asset,” while extent scales were produced for semi‐quantitative RCM “irregular honeycomb,” “mottled pigmentation” and “polycyclic papillary contours.” Qualitative assessment was obtained for RCM type of collagen, and comparison between age groups was performed for all features considered. Severity visual scales assistance proved excellent inter‐rater agreement across all semi‐quantitative and qualitative domains. The assistance of shareable software systems allows for objective OCT quantitative parameters measurement. The use of standard reference scales, within a defined assessment methodology, offers high inter‐rater reliability and thus reproducibility for semi‐quantitative and qualitative OCT and RCM parameters. Taken together, our results may represent a starting point for a standardized application of RCM and OCT in dermo‐cosmetic research and practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

Ciardo

Pezzini

Guida

et al. 2021

Experimental Dermatology

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“…In contrast, TACo was found to preserve skin barrier integrity and function, and has previously been shown not to thin the epidermis. 24 Another human study found that pimecrolimus 1% cream applied twice daily for 3 weeks preserved normal lipid bilayer structures and lamellar body extrusion. 23 Unlike BMV, pimecrolimus upregulates the expression of genes important in maintaining skin barrier function.…”

Section: Discussionmentioning

confidence: 99%

The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis

et al. 2014

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“…21 Furthermore, care must be taken when it is combined with topical corticoids due to its associated effect on these (epidermal atrophy, hypertrichosis, hypopigmentation, cutaneous fragility, telangiectasia, stretch marks). 22 In spite of the questions raised, other authors defend the safety of HQ given that when reviewing the incidence of exogenous ochronosis in the United States, they found that this was scarce. 23 In this study, we have demonstrated that the treatment of melasma with the protocol of the new combination product obtains a significant improvement in the MASI vs. the vehicle-treated side.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma

Truchuelo¹,

Jiménez²,

Jaén³

2014

J of Cosmetic Dermatology

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Summary Background Melasma is a dermatosis with significant repercussions on patients' quality of life, and there is currently no standard treatment. Hydroquinone is deemed the treatment of choice, but its safety has been questioned in certain cases. Aims To determine the efficacy and safety of a new combination of retinoids in the improvement of melasma. Patients/Methods Prospective, double‐blind, vehicle‐controlled, and randomized study in 30 patients with melasma. The product was applied on one side of the face and the vehicle on the other, twice daily during 3 months. Standardized photographs were taken using RBX technology on the three visits (basal, at one and a half months and at 3 months). The main variable to determine the efficacy was the improvement of the hemifacial Melasma Area Severity Index (MASI). Other variables were determined such as improvement perceived by the investigator, improvement perceived by the patient, impact on quality of life or side effects. Results The MASI improvement at 3 months of treatment was significant on the treated side vs. the vehicle side, reaching an improvement of 70%, which is comparable to the percentage of improvement described with hydroquinone. No notable side effects were detected, in spite of a significant percentage of patients included in the study citing a history that could be compatible with sensitive skin. Conclusions This new combination of retinoids and depigmenting agents proved to be effective and safe in the treatment of melasma.

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Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

Cited by 10 publications

References 14 publications

A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis

Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma

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