Morphological Changes and Characteristics of the Expression of Serine Racemase in the Rat Hippocampus in Combined Stress

Смирнов, А. В.; Григорьева, Н В; Ekova, Maria; Шмидт, М В; Медников, Д. С.; Tyurenkov, I. N.; Куркин, Д. В.; Волотова, Е. В.

doi:10.1007/s11055-017-0504-1

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“…Additionally, these findings suggest the absence of sexual dimorphism in SR expression within this particular brain region. Additionally, our findings, revealing a decline in SR expression in the hippocampal subregions with aging, are consistent with previous research indicating a reduction in SR activity in the neuropil of the radial layer of the CA1 field in aged rats exposed to stress [ 58 , 59 ]. This alignment suggests a potential connection between age-related changes in SR expression and stress-induced alterations in hippocampal regions.…”

Section: Discussionsupporting

confidence: 93%

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Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats

Bean,

Bose,

Rani

et al. 2024

Aging

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Aging is associated with a decrease in N-methyl-D-aspartate (NMDA) receptor function, which is critical for maintaining synaptic plasticity, learning, and memory. Activation of the NMDA receptor requires binding of the neurotransmitter glutamate and also the presence of co-agonist D-serine at the glycine site. The enzymatic conversion of L-serine to D-serine is facilitated by the enzyme serine racemase (SR). Subsequently, SR plays a pivotal role in regulating NMDA receptor activity, thereby impacting synaptic plasticity and memory processes in the central nervous system. As such, age-related changes in the expression of SR could contribute to decreased NMDA receptor function. However, age-associated changes in SR expression levels in the medial and lateral prefrontal cortex (mPFC, lPFC), and in the dorsal hippocampal subfields, CA1, CA3, and dentate gyrus (DG), have not been thoroughly elucidated. Therefore, the current studies were designed to determine the SR expression profile, including protein levels and mRNA, for these regions in aged and young male and female Fischer-344 rats. Our results demonstrate a significant reduction in SR expression levels in the mPFC and all hippocampal subfields of aged rats compared to young rats. No sex differences were observed in the expression of SR. These findings suggest that the decrease in SR levels may play a role in the age-associated reduction of NMDA receptor function in brain regions crucial for cognitive function and synaptic plasticity.

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Section: Discussionsupporting

confidence: 93%

“…Interestingly, reduced SR expression was found in additional areas of interest including VH and hypothalamus. Our results of decreased SR expression in the VH with aging align with prior findings indicating reduced SR activity in the neuropil of the radial layer of the CA1 field in aged rats exposed to stress [ 58 , 59 ].…”

Section: Introductionsupporting

confidence: 91%