W e report the usefulness of live three-dimensional transthoracic echocardiogram (3DTTE) in the assessment of a right atrial thrombus in an elderly patient.The patient was a 73-year-old female who presented to our institution with sudden onset of shortness of breath in the middle of the night. Two weeks previously, she had apparently fallen and fractured her left humerus. She also had a history of a cerebral arteriovenous malformation with intracranial hemorrhage and repair about 3 months previously. On examination, she appeared very ill with a heart rate of 131/min, blood pressure 53/26 mm Hg (which subsequently rose to 100 mm Hg systole), respiration 28/min, and an oxygen saturation of 91% on room air. The remainder of the physical examination was unremarkable with clear lungs. The electrocardiogram showed sinus tachycardia and a right bundle branch block with S 1 Q 3 T 3 pattern. A chest x-ray was normal, but a computed tomography scan of the chest showed evidence of thrombi in the right atrium and right pulmonary artery. Because of the history of intracranial hemorrhage, no anticoagulants were administered to the patient.A two-dimensional transthoracic echocardiogram (2DTTE) performed with a Philips Sonos 5500 ultrasound system (Philips Medical Systems, Andover, MA) and a 3.0 MHz transducer showed a dilated right ventricle with a poor ejection fraction of 20%; moderate tricuspid regurgitation with an estimated pulmonary artery systolic pressure of 59 mm Hg; normal left ventricular function; and a large, mobile mass in the right atrium consistent with a thrombus. No masses were visualized in the proximal portion of the main pulmonary artery. The distal portion of the pulmonary artery could not be imaged. It was decided to submit the patient to surgery.Prior to surgery, 3DTTE was performed to further assess the right heart using a Philips Sonos 7500 ultrasound system (Philips Medical Systems, Andover, MA) and a 4 MHz, 4X transducer. Only the apical four-chamber view was utilized; the threedimensional images were systematically cropped and viewed as described previously. 1 All measurements were performed offline using a TomTec CardioView RT System (Munich, Germany). 2 Live 3DTTE showed a large, serpiginous mass in the right atrium, measuring 12 cm in maximum length and 1.2 cm in maximum breadth, with a volume of 24 cc. Systematic and meticulous cropping of the 3DTTE dataset demonstrated no attachment of the thrombus to the right atrial walls or the atrial septum, indicating a free floating thrombus. In addition, en face viewing of the cropped segments of the thrombus showed no evidence of echolucencies within the thrombus, suggesting absence of clot lysis (Figure). 3 At surgery, a large, free thrombus was noted in the right atrium, as well as multiple thrombi in both left and right pulmonary arteries with a saddle embolus at the bifurcation of the main pulmonary artery. The patient underwent pulmonary artery thrombectomy and removal of thrombus in the right atrium using cardiopulmonary bypass and insertion of an...