Morphological and Urodynamic Evaluation of Urinary Bladder Wall Regeneration: Muscles Guarantee Contraction But Not Proper Function—A Rat Model Research Study

Adamowicz, Jan; Juszczak, Kajetan; Bajek, Anna; Tworkiewicz, J.; Nowacki, Maciej; Marszałek, Andrzej; Thor, Piotr; Chłosta, P.; Drewa, Tomasz

doi:10.1016/j.transproceed.2012.01.144

Cited by 30 publications

(22 citation statements)

References 22 publications

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“…However, nonseeded scaffolds failed to show full regeneration of the bladder wall. According to some studies, only approximately 30% of the smooth muscle layer was able to grow back [78]. The failure of cell-free scaffolds to replace bladder can be attributed to many factors.…”

Section: Tissue Engineering Of Urinary Bladdermentioning

confidence: 99%

Tissue Engineering of Urinary Bladder and Urethra: Advances from Bench to Patients

Orabi

Bouhout

Morissette

et al. 2013

The Scientific World Journal

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Urinary tract is subjected to many varieties of pathologies since birth including congenital anomalies, trauma, inflammatory lesions, and malignancy. These diseases necessitate the replacement of involved organs and tissues. Shortage of organ donation, problems of immunosuppression, and complications associated with the use of nonnative tissues have urged clinicians and scientists to investigate new therapies, namely, tissue engineering. Tissue engineering follows principles of cell transplantation, materials science, and engineering. Epithelial and muscle cells can be harvested and used for reconstruction of the engineered grafts. These cells must be delivered in a well-organized and differentiated condition because water-seal epithelium and well-oriented muscle layer are needed for proper function of the substitute tissues. Synthetic or natural scaffolds have been used for engineering lower urinary tract. Harnessing autologous cells to produce their own matrix and form scaffolds is a new strategy for engineering bladder and urethra. This self-assembly technique avoids the biosafety and immunological reactions related to the use of biodegradable scaffolds. Autologous equivalents have already been produced for pigs (bladder) and human (urethra and bladder). The purpose of this paper is to present a review for the existing methods of engineering bladder and urethra and to point toward perspectives for their replacement.

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Section: Tissue Engineering Of Urinary Bladdermentioning

confidence: 99%

Tissue Engineering of Urinary Bladder and Urethra: Advances from Bench to Patients

Orabi

Bouhout

Morissette

et al. 2013

The Scientific World Journal

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“…The implementation of stem cells has evoked tremendous enthusiasm among clinicians. [20][21][22][23][24] In the present study, we aimed to determine the local and systemic effects and utility of adipose-derived stem cells (ADSCs) as a component of dermal fillers in an in vivo rat model.…”

Section: Researchmentioning

confidence: 99%

Filling Effects, Persistence, and Safety of Dermal Fillers Formulated With Stem Cells in an Animal Model

Nowacki¹,

Pietkun

Pokrywczyńska³

et al. 2014

Aesthetic Surgery Journal

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“…Moreover, the material has to support adequate smooth muscle regeneration. This is best accomplished by seeding the scaffold with smooth muscle cells 15. Achieving an appropriately thick muscular layer will allow the regenerated tissue to be robust, withstanding rupture if overfilled with urine.…”

Section: Properties Of An Ideal Biomaterials For Urinary Tract Substitmentioning

confidence: 99%

Biofabrication and biomaterials for urinary tract reconstruction

Elsawy

Mel

2017

RRU

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Reconstructive urologists are constantly facing diverse and complex pathologies that require structural and functional restoration of urinary organs. There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patient’s autologous tissues with its associated morbidity. Biomimetic approaches are tissue-engineering tactics aiming to tailor the material physical and biological properties to behave physiologically similar to the urinary system. This review highlights the different strategies to mimic urinary tissues including modifications in structure, surface chemistry, and cellular response of a range of biological and synthetic materials. The article also outlines the measures to minimize infectious complications, which might lead to graft failure. Relevant experimental and preclinical studies are discussed, as well as promising biomimetic approaches such as three-dimensional bioprinting.

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Morphological and Urodynamic Evaluation of Urinary Bladder Wall Regeneration: Muscles Guarantee Contraction But Not Proper Function—A Rat Model Research Study

Cited by 30 publications

References 22 publications

Tissue Engineering of Urinary Bladder and Urethra: Advances from Bench to Patients

Tissue Engineering of Urinary Bladder and Urethra: Advances from Bench to Patients

Filling Effects, Persistence, and Safety of Dermal Fillers Formulated With Stem Cells in an Animal Model

Biofabrication and biomaterials for urinary tract reconstruction

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