Environmental sustainability is an integral aspect of living a better life, which will continue to be globally highlighted in the future. Sustainable Development Goals (SDGs) are crucial in most research areas to improve natural resources that will ensure the long-term viability of the environment. The rising population may lead to increased pollution due to extensive anthropogenic activities. Natural resources are being increasingly exploited by an ever-increasing human population and rising per capita consumption. A combination of biotechnological approaches to strengthen environmental sustainability in plant fields has often been used. Azolla, an aquatic fern, is a promising candidate for worldwide application and is well established in biotechnology, particularly focusing on environmental sustainability. This review aims to explore the prospective of Azolla using a biotechnology approach. This review highlights current and future research and presents viewpoints on the importance of biotechnology in phytoremediation, genomics, and the animal feed industry.