1986
DOI: 10.1038/bjc.1986.33
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Morphological and isoenzymatic differentiation of B-chronic lymphocytic leukaemia cells induced by phorbolester

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Cited by 36 publications
(4 citation statements)
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References 16 publications
(15 reference statements)
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“…This isoenzyme could be induced by the phorbolester 12-0-tetradecanoylphorbol 13-acetate (TPA) and by a T-cell-conditioned medium in the myelomonocytic leukaemia cell lines ML-3, THP-1, U-937 and HL-60 undergoing differentiation to monocyte-/macrophage-like cells (24). All cases of B-CLL and CML which were treated with TPA and differentiated along the B-cell axis and to monocyte-macrophages, respectively, displayed the tartrate-resistant band after several days of exposure to the inducing agent (22,23). In the present study, only the monocytic variants FAB M4 and FAB M5 showed the tartrate-resistant isoenzyme, whereas the 'granulocytic' subtypes FAB Ml-M3 and the erythroleukaemia cases (FAB M6) did not.…”
Section: Discussioncontrasting
confidence: 47%
See 1 more Smart Citation
“…This isoenzyme could be induced by the phorbolester 12-0-tetradecanoylphorbol 13-acetate (TPA) and by a T-cell-conditioned medium in the myelomonocytic leukaemia cell lines ML-3, THP-1, U-937 and HL-60 undergoing differentiation to monocyte-/macrophage-like cells (24). All cases of B-CLL and CML which were treated with TPA and differentiated along the B-cell axis and to monocyte-macrophages, respectively, displayed the tartrate-resistant band after several days of exposure to the inducing agent (22,23). In the present study, only the monocytic variants FAB M4 and FAB M5 showed the tartrate-resistant isoenzyme, whereas the 'granulocytic' subtypes FAB Ml-M3 and the erythroleukaemia cases (FAB M6) did not.…”
Section: Discussioncontrasting
confidence: 47%
“…Cytochemical studies demonstrated tartrate-resistant acP activity in activated macrophages (12,19), in stimulated peripheral blood monocytes (20), in alveolar macrophages (20) and in the peripheral blood monocytes from patients with Gaucher disease (21), but not in unstimulated normal peripheral blood monocytes (20). Pre-viously, we showed that isoelectric focusing studies are more sensitive than cytochemical techniques in detecting tartrate-resistant acP (22,23). Future studies will determine whether there exist different (cell type-specific?)…”
Section: Discussionmentioning
confidence: 91%
“…Recently, late cardiovascular events have also been described in long-term survivors of testicular cancer treated with platinum-based chemotherapy [ 9 , 10 ]. In addition, vascular damage is known to be induced by therapeutic irradiation [ 11 , 12 ]. It has been found that CCS who received irradiation of the brain and/or neck are at increased risk for stroke [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…In the first of these Ellis et al (1978) described the increased abundance of the I2 form in lymphocytes from patients with common acute lymphoblastic leukaemia (c-ALL), a characteristic that has been used as a marker in distinguishing common acute lymphoblastic leukaemia from other types ofleukaemia (Greaves, 1981). /8-N-Acetylhexosaminidase 12 was initially demonstrated in leukaemic cells by DEAE-cellulose chromatography, but it has also been detected in pre B-ALL, AUL, Null-ALL and AML as well as in c-ALL cells by isoelectric focusing (Drexler et al, 1984).…”
Section: Introductionmentioning
confidence: 99%