Morphological and histopathological changes in placentas of pregnancies with intrauterine growth restriction

Vişan, Valeria; Bălan, Raluca; Costea, Claudia Florida; Cărăuleanu, Alexandru; Haba, Raluca Maria; Haba, Mihai Ștefan Cristian; Socolov, Demetra; Mogos, Raluca; Bogdănici, Camelia Margareta; Nemescu, Dragoş; Turliuc, Mihaela Dana; Cucu, Andrei; Scripcariu, Dragoş Viorel; Toma, Bogdan Florin; Popovici, Răzvan; Ciocoiu, Manuela; Petrariu, F.D.

doi:10.47162/rjme.61.2.17

Cited by 13 publications

(5 citation statements)

References 30 publications

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“…In the present study, intervillous fibrin was significantly increased in the IUGR group than in the control group. This is consistent with the results of other studies ( Nigam et al, 2014 , Visan et al, 2020 ). The presence and expansion of intervillous fibrin are strongly correlated with a reduction in placental and fetal weight ( Redline 2008 ).…”

Section: Discussionsupporting

confidence: 94%

“…IUGR may be affected by maternal, fetal, or placental factors ( Sharma, Shastri and Sharma 2016 ); however, placental factors are considered essential causes in many IUGR cases ( Visan et al 2020 ). Studies have revealed the association of IUGR with placental changes, such as placental weight, fetal/placental weight ratio, type of umbilical cord insertion in the placenta, and its diameter ( Visan, Balan, Costea, Carauleanu, Haba, Haba, Socolov, Mogos, Bogdanici, Nemescu, Tanase, Turliuc, Cucu, Scripcariu, Toma, Popovici, Ciocoiu and Petrariu 2020 ). A small placenta is associated with an increased risk of IUGR ( Ducray et al 2011 ).…”

Section: Introductionmentioning

confidence: 99%

“…More specifically, IUGR has been linked to reduced volume and surface area of placental villi ( Teasdale 1984 ). Placentas in IUGR pregnancies are characterized by several histopathological phenotypes such as chronic villitis, avascular villi, villous infarction, distal villous hypoplasia, perivillous fibrinoid deposition, cytotrophoblast hyperplasia, syncytial knots, chorangiosis, and basement membrane thickening ( Almasry et al, 2012 , Veerbeek et al, 2014 , Visan et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Stereological and histopathological assessment of intrauterine growth restriction placenta from Saudi women

Mojammamy

Alayed²,

Aljerian³

et al. 2023

Saudi Journal of Biological Sciences

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stereological and histopathological assessment of intrauterine growth restriction placenta from Saudi women

Mojammamy

Alayed²,

Aljerian³

et al. 2023

Saudi Journal of Biological Sciences

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“…On the other hand, a placental infarct consists of necrosis of a foetal cotyledon caused by occlusion of the supplying uteroplacental artery. However, as previously mentioned in the method section, placental infarcts are areas of low T2 signal or sometimes high T2 intensity with low signal rim, usually in the background of presence of a thick placenta [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic models for the detection of intrauterine growth restriction and placental insufficiency severity based on magnetic resonance imaging of the placenta

Moradi¹,

Tabibian²,

Kazemi³

et al. 2023

Pol J Radiol

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Purpose We aimed to provide diagnostic models based on different parameters of placental magnetic resonance imaging (MRI) to detect intrauterine growth restriction (IUGR), as well as the severity of placental insufficiency. Material and methods We included 44 foetuses with appropriate weight for gestational age (AGA) and 46 foetuses with documented IUGR, defined as the estimated foetal weight (EFW) below the 10 th centile. Using Doppler ultrasound, IUGR cases were divided into 2 groups: 1) IUGR with severity signs: EFW < 3 rd centile, or cerebroplacental ratio < 5 th centile, or abnormal umbilical/uterine artery pulsatility index; and 2) non-severe IUGR without any of this criterion. For all these participants, placental MRI was performed in the third gestational trimester, and its parameters were compared between AGA and IUGR, as well as between the severe and non-severe IUGR groups. Two diagnostic models consisting of significant predictors were developed, and their performance was investigated with accuracy metrics. Results The severity signs were detected in 25 (54.3%) IUGR cases. The diagnostic model for the differentiation of IUGR from AGA revealed an acceptable performance (area under the curve [AUC] of 0.749) and consisted of 2 variables: 1) the largest size of infarct ≥ 25 mm (odds ratio [OR] = 5.01, p = 0.001), and 2) thickness : volume ratio ≥ 0.043 (OR = 3.76, p = 0.027); while, the logistic regression model for detection of the severity signs was even better, with AUC = 0.862, and comprised of 2 predictors: 1) placental infarct percent ≥ 10% (OR = 26.73, p = 0.004), and 2) placental globular shape (OR = 5.40, p = 0.034). Conclusions Placental MRI parameters can differentiate IUGR from AGA, and more precisely, assess the severity of placental insufficiency in IUGR foetuses.

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“…One of the very common causes of growth restriction is the placental factor because placental structure and function affect the transport and exchange of gases and nutrients, as well as the products of metabolism at the level of uteroplacental circulation [3]. Ultrasound fetal measurements and other markers present the most common diagnostic method for prediction and diagnosing of FGR.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and ultrasonographic markers in fetal surveillance

2023

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Introduction/Objective. Fetal growth restriction (FGR) is associated with increased fetal and neonatal mortality and morbidity. The study objective was to investigate the correlation of maternal blood biochemical markers routinely determined in the first and second trimester screening and ultrasound fetal surveillance parameters in the prediction of fetal growth and condition in singleton pregnancies. Methods. In the first trimester we measured serum levels of beta subunit of human chorionic gonadotropin (?HCG) and pregnancy-associated plasma protein A (PAPP-A). In the second trimester we measured values of chorionic gonadotropin (HCG), alpha feto-protein (AFP), unconjugated estriol (E3) and inhibin A, also examined ultrasonographic biometric fetal parameters, amniotic fluid index (AFI) and Doppler resistance indexes. FGR was defined as ultrasonographically determined fetal weight and growth parameters below the 10th percentile for the gestational age. Obtained biochemical and ultrasonographic parameters were correlated. Results. Study included 104 singleton pregnancies. ?HCG in the first trimester negatively correlated with fetal growth in the second and third trimester, and the second trimester AFI. Increased PAPP-A correlated positively with elevated resistance index in medial cerebral artery, lower biophysical profile scores, and intermediate type of non-stress test. Lower values of E3 were associated with FGR. Elevated serum AFP levels were linked to oligoamnion in the third trimester. There was no correlation of inhibin A levels with fetal condition. Conclusion. First and second trimester biochemical markers of pregnancy (?HCG, PAPP-A, HCG, AFP and E3) in combination with ultrasonographic biophysical parameters of fetus have predictive value for fetal growth and development.

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Morphological and histopathological changes in placentas of pregnancies with intrauterine growth restriction

Cited by 13 publications

References 30 publications

Stereological and histopathological assessment of intrauterine growth restriction placenta from Saudi women

Stereological and histopathological assessment of intrauterine growth restriction placenta from Saudi women

Diagnostic models for the detection of intrauterine growth restriction and placental insufficiency severity based on magnetic resonance imaging of the placenta

Biochemical and ultrasonographic markers in fetal surveillance

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