Morphological and Histochemical Studies on Fibrillopathia Epitheliocapsularis

Fluorescein angiography of the iris (IFAG) was performed on 15 patients with a positive cyclopentolate response (IOP elevation greater than or equal to 8 mmHg) in 17 eyes to the cyclopentolate provocative test. The chamber angles were open in all the eyes. Seven of the responder eyes had capsular glaucoma undergoing treatment, six had simple glaucoma, two had pigmentary glaucoma and two suspicion of open-angle glaucoma. The object was to study with IFAG whether vascular changes can be established in the iris of the responder eyes such as could have a role in the elevation of IOP. All the eyes with capsular glaucoma displayed vascular changes, vasoproliferation and fluorescein leakage from the iris vessles. No other vascular changes were seen in the irises of the responder eyes. IFAG revealed no differences in the iris vasculature between responder and non-responder eyes. A vascular aetiology for the IOP elevation in responders is improbable.

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

The Cyclopentolate Provocative Test in Suspected or Untreated Open‐angle Glaucoma

Valle

Vannas

1976

“…The enzyme 0-chymotrypsin has no effect on the known inclusions of the lens capsule and the capsula propria when used in "clinical concentrations" (20 mg/100 ml) for very short periods (Salmony 1959;Bertelsen & Ehlers 1969;Fisher & Pettet 1972;Seland & Slagsvold 1977).…”

Section: Discussionmentioning

confidence: 98%

The Ultrastructure of the Human Lens Capsule Ii. Cataracta Complicata

Seland

1978

Eight human cataractous lenses extracted from eyes suffering from uveitis have been examined by transmission electron microscopy. The following changes have been demonstrated: cellular proliferation, fibrillogenesis and formation of osmiophilic, electron-dense amorphous structures. The changes were most pronounced in young lenses but had no features in common with the FEC (fibrillopathia epitheliocapsularis) syndrome.

“…This has also been recorded by Bertelsen & Ehlers (1969) after their studies of enzymatic digestion of sections of lenses with PE.…”

Section: Discussionmentioning

confidence: 99%

A Method of Isolating and Collecting Pseudo‐exfoliation Material From Extracted Cataractous Lenses

Davanger

1977

It has been observed that the pseudo-exfoliation (PE) material on the surface of extracted lenses was not dissolved by a papain solution, while the underlying lens capsule was digested. This forms the basis of a method for isolating and collecting PE material. The anterior lens surface was swept with a cilium after the lens had been suspended in a 5% papain solution for 1/2-1 hour. The PE material was loosened in flakes which adhered to the tip of the cilium and could be collected as a lump. By light and scanning and transmission electron microscopy no contaminants could be seen, and no damage to the PE material was disclosed.