“…Increased physical activity in interventional studies may result in a variety of effects including, but not limited to, improved resting cerebrovascular reactivity to hypercapnia (Murrell et al, 2013), reduced arterial pressure (Vicente-Campos et al, 2012), lower total cholesterol and triglycerides (Vicente-Campos et al, 2012), lower BMI and blood pressure (Stewart et al, 2013), better glycemic control (Roberts et al, 2013), reduced chronic low-grade inflammation (Nimmo et al, 2013), increased growth factor levels (Cotman and Berchtold, 2002), better sleep (Dzierzewski et al, 2014), and greater brain neurogenesis (Cotman and Berchtold, 2002). Many of these effects relate to health factors that may modulate AD risk (Launer et al, 2000; Del Bo et al, 2009; Solomon et al, 2009; Lee et al, 2010; Matsuzaki et al, 2011; Piriz et al, 2011; Vargas et al, 2011; Crane et al, 2013; Tolppanen et al, 2013; Di Meco et al, 2014).…”