Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance

Джалилова, Д. Ш.; Косырева, А. М.; Цветков, И.С.; Золотова, Н.А.; Мхитаров, В А; Михайлова, Л. П.; Makarova, Olga

doi:10.1007/s10517-020-04989-1

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Джалилова и соавт. [23] и G. Afshan et al [24] выявили более высокое содержание Т-регуляторных лимфоцитов у самцов крыс и у мужчин по сравнению с самками и с женщинами, соответственно, что согласуется с полученными нами результатами. Однако Ю. Гао и соавт.…”

Section: результаты и обсуждениеunclassified

Morphofunctional changes in the colon and immune responses during cold stress in male and female C57BL/6 mice

Золотова¹,

Цветков²,

Джалилова³

et al. 2020

Clin. Exp. Morphology

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Introduction. Stress is one of the factors contributing to the gastrointestinal tract diseases development and exacerbating the course of diseases of the gastrointestinal tract. The cold factor is the most common stress factor in Russia. Therefore, the aim of our work was to characterize the immune responses and colon morphological and functional changes during cold stress in male and female C57BL/6 mice. Materials and methods. We studied alterations in the subpopulation composition of peripheral blood lymphocytes and morphofunctional changes in the thymus, spleen, and colon in response to a course intermittent cold exposure during 35-minute sessions for 14 days at –20° in adult male and female C57BL/6 mice. Results. The volume fraction of the PALS zone of the spleen and the content of endocrine cells in the colon decreased in animals of both sexes in the cold stress conditions. In females, the number of platelets and leukocytes in the peripheral blood increased, the width of the subcapsular zone of the thymus decreased, and the volume fraction of the red spleen pulp increased. In males, in the peripheral blood, the absolute and relative content of T-regulatory lymphocytes decreased, and the relative content of activated T-helpers increased, the volume fraction of the light centers of lymphoid nodules in the spleen decreased, the length of the crypts increased in the colon. A number of differences between males and females of control groups were also revealed: in the peripheral blood, males had more platelets and the absolute content of T-regulatory lymphocytes and less absolute content of T-cytotoxic. In the colon of males, the content of proliferating epithelial cells in the colon was higher than the one in females, and the bulk density of goblet cells was lower in males. Conclusion. Under the cold stress factor exposure in animals, physiological stress develops. Immune reactions and colon morphofunctional changes in the colon during cold stress differ between males and females. Keywords:cold stress, sex differences, colon, immune system

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Section: результаты и обсуждениеunclassified

Morphofunctional changes in the colon and immune responses during cold stress in male and female C57BL/6 mice

Золотова¹,

Цветков²,

Джалилова³

et al. 2020

Clin. Exp. Morphology

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Multi-omics analysis identifies sex-specific hepatic protein-metabolite networks in yellow catfish (Pelteobagrus fulvidraco) exposed to chronic hypoxia

Zhao,

Song,

Zhang

et al. 2024

International Journal of Biological Macromolecules

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Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

Джалилова

Makarova

2020

Biomedicines

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Hypoxia plays an important role in the development of many infectious, inflammatory, and tumor diseases. The predisposition to such disorders is mostly provided by differences in basic tolerance to oxygen deficiency, which we discuss in this review. Except the direct exposure of different-severity hypoxia in decompression chambers or in highland conditions, there are no alternative methods for determining organism tolerance. Due to the variability of the detection methods, differences in many parameters between tolerant and susceptible organisms are still not well-characterized, but some of them can serve as biomarkers of susceptibility to hypoxia. At the moment, several potential biomarkers in conditions after hypoxic exposure have been identified both in experimental animals and humans. The main potential biomarkers are Hypoxia-Inducible Factor (HIF)-1, Heat-Shock Protein 70 (HSP70), and NO. Due to the different mechanisms of various high-altitude diseases, biomarkers may not be highly specific and universal. Therefore, it is extremely important to conduct research on hypoxia susceptibility biomarkers. Moreover, it is important to develop a method for the evaluation of organisms’ basic hypoxia tolerance without the necessity of any oxygen deficiency exposure. This can contribute to new personalized medicine approaches’ development for diagnostics and the treatment of inflammatory and tumor diseases, taking into account hypoxia tolerance differences.

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Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance

Cited by 3 publications

References 14 publications

Morphofunctional changes in the colon and immune responses during cold stress in male and female C57BL/6 mice

Morphofunctional changes in the colon and immune responses during cold stress in male and female C57BL/6 mice

Multi-omics analysis identifies sex-specific hepatic protein-metabolite networks in yellow catfish (Pelteobagrus fulvidraco) exposed to chronic hypoxia

Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

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