Morphological and functional demonstration of rat dura mater mast cell–neuron interactions in vitro and in vivo

Rózniecki, J; Dimitriadou, Violetta; Lambracht-Hall, M.; Pang, Xinzhu; Theoharides, Theoharis C.

doi:10.1016/s0006-8993(99)01855-7

Cited by 209 publications

(166 citation statements)

References 82 publications

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“…Human experimental studies suggest that parasympathetic activation is pronociceptive, in that migraine pain is reduced after anesthetic blocking of the parasympathetic sphenopalatine ganglion. 26,27 Because parasympathetic and trigeminal fibers are closely related in the perivascular space, 28 it is possible that PACAP released from either system could lead to modulation of sensory input in trigeminal neurons.…”

Section: The Peripheral Actions Of Pacapmentioning

confidence: 99%

The PACAP Receptor: A Novel Target for Migraine Treatment

2010

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Summary:The origin of migraine pain has not yet been clarified, but accumulating data point to neuropeptides present in the perivascular space of cranial vessels as important mediators of nociceptive input during migraine attacks. Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in sensory trigeminal neurons and may modulate nociception at different levels of the nervous system. Human experimental studies have shown that PACAP-38 infusion induces marked dilatation of extracerebral vessels and delayed migraine-like attacks in migraine patients. PACAP selectively activates the PAC 1 receptor, which suggests a possible signaling pathway implicated in migraine pain. This review summarizes the current evidence supporting the involvement of PACAP in migraine pathophysiology and the PAC 1 receptor as a possible novel target for migraine treatment.

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Section: The Peripheral Actions Of Pacapmentioning

confidence: 99%

The PACAP Receptor: A Novel Target for Migraine Treatment

2010

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“…t has long been demonstrated that mast cells are closely apposed to nerves in a variety of tissues, including skin, intestine, and dura mater (1)(2)(3)(4)(5). Some mast cells actually form membrane-membrane contact with nerve cells in vivo (1,2).…”

mentioning

confidence: 99%

“…Some mast cells actually form membrane-membrane contact with nerve cells in vivo (1,2). In addition, nerves in association with mast cells often contain neuropeptides, such as substance P (SP) 4 and calcitonin gene-related peptide (1,6). Because nerves release these neuropeptides on stimulation, and mast cells express receptors for many neuropeptides (5,(7)(8)(9)(10), nerve activation results in mast cell activation, i.e., degranulation or secretion of mediators (11).…”

mentioning

confidence: 99%

The Spermatogenic Ig Superfamily/Synaptic Cell Adhesion Molecule Mast-Cell Adhesion Molecule Promotes Interaction with Nerves

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Ito

Koma

et al. 2005

The Journal of Immunology

106

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Nerve-mast cell interaction is involved in both homeostatic and pathologic regulations. The molecules that sustain this association have not been identified. Because synaptic cell adhesion molecule (SynCAM), alternatively named spermatogenic Ig superfamily (SgIGSF), is expressed on both nerves and mast cells and because it binds homophilically, this molecule may be a candidate. To examine this possibility, mast cells with or without SgIGSF/SynCAM were cocultured with superior cervical ganglion neurons that express SgIGSF/SynCAM, and the number of mast cells attached to neurites was counted. The attachment of mast cells with SgIGSF/SynCAM, i.e., bone marrow-derived mast cells (BMMC) from wild-type mice, was inhibited dose-dependently by blocking Ab to SgIGSF/SynCAM. Mast cells without SgIGSF/SynCAM, i.e., BMMC from microphthalmia transcription factor-deficient mice and BMMC-derived cell line IC-2 cells, were defective in attachment to neurite, and transfection with SgIGSF/SynCAM normalized this. When the nerves were specifically activated by scorpion venom, one-quarter of the attached IC-2 cells mobilized Ca2+ after a few dozen seconds, and ectopic SgIGSF/SynCAM doubled this proportion. At points of contact between neurites and wild-type BMMC, SgIGSF/SynCAM was locally concentrated in both neurites and BMMC. SgIGSF/SynCAM on mast cells appeared to predominantly mediate attachment and promote communication with nerves.

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“…Hypothalamic mast cells are located close to nerve endings that contain CRH and can be activated by acute stress (Rozniecki et al, 1999). Acute stress can trigger mast cell degranulation (Singh et al, 1999) and increased the number of skin mast cells and also can worsened delayed hypersensitivity, effects blocked by pretreatment with a CRH receptor antagonist (Kaneko et al, 2003).…”

Section: Keratinocytes -Crh and Mast Cellsmentioning

confidence: 99%