Morphological and Functioinal Alterations Noted after Baboon Renal Allotransplantation

Weber, Herbert; Brede, H. D.; Retief, François; Retief, C.P.; Zyl, J. A. Van; Groenewald, J. H.; Zyl, J. J. W. Van; Murphy, Gerald P.

doi:10.1016/s0022-5347(17)62366-8

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…-Treatment of rats with corticosterone likewise induces an aging-like behavior of tail tendons (8). Some investigators (9) feel that the decreasing ability to overcome stress is the principal expression of aging.…”

Section: Warner-lambert Research Institute Morris Plains New Jerseymentioning

confidence: 99%

“…Isometric tension of contracting tendons was determined by previously described methods (8). Materials.…”

Section: Warner-lambert Research Institute Morris Plains New Jerseymentioning

confidence: 99%

“…The techniques and methods of study for baboon renal allotransplantation have been described in detail previously (8,9). The techniques and methods of study for baboon renal allotransplantation have been described in detail previously (8,9).…”

mentioning

confidence: 99%

“…The techniques and methods of study for baboon renal allotransplantation have been described in detail previously (8,9). These included PAH clearance, endogenous creatinine clearance, total blood urea (mg/100 ml) ; and peripheral hematocrit (8). The present report describes ESF alterations observed in 13 adult male and female chacma baboons after renal allotransplantation.…”

mentioning

confidence: 99%

“…Few animals with such renal grafts survive beyond 14 days, and therefore further postoperative observations in this untreated group are not possible (8). Few animals with such renal grafts survive beyond 14 days, and therefore further postoperative observations in this untreated group are not possible (8).…”

mentioning

confidence: 99%

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Erythropoietin Release in Baboons after Renal Allotransplantation

Mirand¹,

Steeves²,

Zyl³

et al. 1968

Experimental Biology and Medicine

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Section: Warner-lambert Research Institute Morris Plains New Jerseymentioning

confidence: 99%

“…Isometric tension of contracting tendons was determined by previously described methods (8). Materials.…”

Section: Warner-lambert Research Institute Morris Plains New Jerseymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Erythropoietin Release in Baboons after Renal Allotransplantation

Mirand¹,

Steeves²,

Zyl³

et al. 1968

Experimental Biology and Medicine

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Correlation of urinary isoenzymes in baboon renal allografts and autografts

Groenewald

Bersohn

Zyl

et al. 1969

Journal of Surgical Oncology

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Urinary and blood isoenzymes and other biochemical tests were performed on fresh or fresh-frozen specimens from intact renal-allografted or renal-autografted adult male and female Chacma baboons. Although elevations in urinary and blood LDH and alkaline phosphatase activity were noted, these failed to prove consistent, or to be specific indices of renal rejection, or to correlate with the level of measured renal function. LDH urinary enzymes as determined by paper electrophoresis disclosed a heretofore undescribed shift from a high, fast-moving fraction (I) in renal-allografted or renal-autografted animals. The shift is therefore not related to renal rejection, but more to nonspecific ischemic cellular destruction. Techniques of starch gel and paper urinary isoenzyme measurements are compared, and the necessity of fresh catheterized specimens for accurate enzymatic determination is stressed.

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The effect of cinanserin (antiserotonin agent) on canine renal allografts

Murphy

Brede

Weber

et al. 1970

Journal of Surgical Oncology

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A new compound, cinanserin, which possesses antiserotonin as well as immunosuppressive properties, was tested in dog renal allografts. Increased survival rates were noted a t a dose level of 40 mg/kg/day. Increasing drug therapy above this level was associated with hepatotoxicity. There was no evidence of bone marrow toxicity. Histologically, characteristic features of allograft rejection were generally unmodified. Serological alterations seen in untreated renal allografts were generally suppressed t o a limited degree.

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Morphological and Functioinal Alterations Noted after Baboon Renal Allotransplantation

Cited by 6 publications

References 7 publications

Erythropoietin Release in Baboons after Renal Allotransplantation

Erythropoietin Release in Baboons after Renal Allotransplantation

Correlation of urinary isoenzymes in baboon renal allografts and autografts

The effect of cinanserin (antiserotonin agent) on canine renal allografts

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