Morphological and chemical characterization of Arnica montana L. under different cultivation models

Pljevljakušić, Dejan; Janković, Teodora; Jelačic, S.; Novaković, Miroslav; Menković, Nebojša; Beatovic, D.; Dajić-Stevanović, Zora

doi:10.1016/j.indcrop.2013.10.035

Cited by 26 publications

(32 citation statements)

References 26 publications

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“…In the case of Arnica spp., the knowledge of the role of nutrients as factors modifying the content, yield, and chemical composition of EO is insufficient [17,29]; therefore, the results presented in this paper partially fill in this gap. Another argument confirming the validity of our research is the rapid growth in the industrial demand for medicinal plants and herbal medicines worldwide, which has contributed to intensification of the cultivation of the species and search for new sources of secondary metabolites in recent years [17,31,[57][58][59][60]. The effects of application of nutrients or the soil type and properties on the quality and quantity of secondary metabolites in EO from arnica flower heads have not been investigated so far.…”

Section: Introductionmentioning

confidence: 55%

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

et al. 2019

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Chamisso arnica (Arnica chamissonis Less.) is a valuable plant species used in the pharmaceutical industry due to the content of many pharmacologically active substances and the similarity of its chemical composition to that of Arnica montana—a medicinal plant commonly used in pharmacy and cosmetics. The similarity of the two plant species implies that chamisso arnica can be a pharmaceutical substitute for the mountain arnica, i.e., an endangered and endemic plant species in Europe. Chamisso arnica extracts exhibit anti-inflammatory and antiradical activity and possesses high antioxidant properties that might be helpful in preventing or delaying the progress of free radical dependent diseases. The attributes of A. chamissonis are mainly related to the content and chemical composition of essential oil. Therefore, the objective of this study was to characterize the chemical composition of essential oil derived from A. chamissonis flower heads under a nitrogen impact. The experiment was performed on experimental fields in mid-eastern Poland on two soil types (sandy and loamy soils). The nitrogen fertilizer was applied as ammonium sulfate (control, 30, 60, 90, and 120 kg N ha−1). Collection of flower heads was carried out in the full flowering phase, which was characterized by the highest content of essential oil. The chemical composition of essential oil was examined using GC-MS. Among the 75 ingredients of the volatile oil of chamisso arnica flower heads, alpha-pinene, cumene, p-cymene, germacrene D, spathulenol, decanal, caryophyllene oxide, beta-pinene, and benzene acetaldehyde were present at relatively high levels. Both the nitrogen application and the soil type had an effect on the oil concentration and the yield of the main constituents (alpha-pinene and germacrene D) with pharmacological value. Different levels of nitrogen application could be considered as a relevant way to modify the chemical composition and to increase the essential oil production.

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Section: Introductionmentioning

confidence: 55%

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

et al. 2019

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“…Arnica montana L. is a source of several active compounds (sesquiterpene lactones, flavonoids, terpenoids, phenolic acids, and essential oils) exhibiting antibacterial, antifungal, antiseptic, anti-inflammatory, antiradical, antisclerotic, and antioxidant activities [1,2,3,4,5,6,7,8,9]. The chemical composition of essential oil (EO) and its major volatile components in arnica may vary depending on the geographical region and environmental factors [4,5,6,7,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil from Arnica Montana L. Achenes: Chemical Characteristics and Anticancer Activity

Sugier

Jakubowicz-Gil

et al. 2019

Molecules

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Mountain arnica Arnica montana L. is a source of several metabolite classes with diverse biological activities. The chemical composition of essential oil and its major volatile components in arnica may vary depending on the geographical region, environmental factors, and plant organ. The objective of this study was to characterize the chemical composition of essential oil derived from A. montana achenes and to investigate its effect on induction of apoptosis and autophagy in human anaplastic astrocytoma MOGGCCM and glioblastoma multiforme T98G cell lines. The chemical composition of essential oil extracted from the achenes was examined with the use of Gas Chromatography–Mass Spectrometry GC-MS. Only 16 components of the essential oil obtained from the achenes of 3-year-old plants and 18 components in the essential oil obtained from the achenes of 4-year-old plants constituted ca. 94.14% and 96.38% of the total EO content, respectively. The main components in the EO from the arnica achenes were 2,5-dimethoxy-p-cymene (39.54 and 44.65%), cumene (13.24 and 10.71%), thymol methyl ether (8.66 and 8.63%), 2,6-diisopropylanisole (8.55 and 8.41%), decanal (7.31 and 6.28%), and 1,2,2,3-tetramethylcyclopent-3-enol (4.33 and 2.94%) in the 3- and 4-year-old plants, respectively. The essential oils were found to exert an anticancer effect by induction of cell death in anaplastic astrocytoma and glioblastoma multiforme cells. The induction of apoptosis at a level of 25.7–32.7% facilitates the use of this secondary metabolite in further studies focused on the development of glioma therapy in the future. Probably, this component plays a key role in the anticancer activity against the MOGGCCM and T98G cell lines. The present study is the first report on the composition and anticancer activities of essential oil from A. montana achenes, and further studies are required to explore its potential for future medicinal purposes.

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“…After many pharmacological experiments carried out in recent decades, Arnica montana has shown primarily the anti-inflammatory action on various inflammation models. This is the main action and the most important one mentioned in the literature [50,51]. Among the compounds present in the Arnica montana, the sesquiterpene lactones, helenaline type, helenaline esters and 11,13-dihydrohelenaline esters with acetic, isobutyric, isovalerianic and tiglic acids, are responsible for the antiinflammatory action, reflected also by the European Pharmacopoeia which stipulates that arnica flowers must have a minimum content of 0.4 % expressed as helenalinetiglinat [51,52,53].…”

Section: Arnica Montana (Arnica)mentioning

confidence: 99%

Medicinal herbs as possible sources of anti-inflammatory products

Corciovă¹,

Matei²,

Ivănescu³

2017

Balneo

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Plants constitute an inexhaustible source of bioactive compounds that can be valuable for research in the chemistry field of antiinflammatory compounds. This review describes several plants from international and national flora that have been shown to have anti-inflammatory activity in various clinical trials. The paper includes: general aspects regarding the vegetal source, compounds responsible for anti-inflammatory activity, mechanism of action and clinical trials carried out with extracts or products containing standardized extracts.

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Morphological and chemical characterization of Arnica montana L. under different cultivation models

Cited by 26 publications

References 26 publications

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

Chemical Composition of Essential Oil from Flower Heads of Arnica Chamissonis Less. under a Nitrogen Impact

Essential Oil from Arnica Montana L. Achenes: Chemical Characteristics and Anticancer Activity

Medicinal herbs as possible sources of anti-inflammatory products

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