Experimental and Molecular Pathology

1980

DOI: 10.1016/0014-4800(80)90043-x

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Morphological and biochemical differences among grossly-defined types of swine aortic atherosclerotic lesions induced by a combination of injury and atherogenic diet

Katherine Fritz¹,

Joan M. Augustyn³

et al.

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1982

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Cited by 29 publications

(7 citation statements)

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“…% Fuster et al, 1978. inspected for lesions. Only one type of lesion was seen (Mitchell and Schwartz, 1965;Fritz et al, 1980;Griggs et al, 1981): a raised fibrous arteriosclerotic plaque consisting of a firm, gray, prominent elevation with predominantly collagen and elastic bundles, as detected microscopically. Quantification was done by recording the proportion of the aortic area affected.…”

Section: Postmortem Analysismentioning

confidence: 99%

“…In all of the studies, a distal aortic segment proximal to the trifurcation was chosen for transplantation because this region is most prone to the development of arteriosclerosis (Fritz et al, 1980;Griggs et al, 1981). The operation was done as follows: At 3 months of age, the 25 pigs underwent general anesthesia induced with ether and maintained with halothane.…”

Section: Operationmentioning

confidence: 99%

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Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study.

Fass²,

et al. 1982

Circulation Research

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In a long-term prospective study, five normal control pigs and five pigs with homozygous von Willebrand's disease received a nonfatty diet from age 3 months to 4 years; then the aortas were analyzed. The fibrous arteriosclerotic plaques in the distal abdominal aortic region involved an average of 28% of the surface area in control pigs and only 7% of the surface area in pigs with von Willebrand's disease (P less than 0.01). In a subsequent study of 3-month-old pigs, the distal abdominal aortic segments from nine normal pigs were cross-transplanted with segments from nine other normal pigs (control study), and aortic segments from four normal pigs were transplanted into four host pigs with von Willebrand's disease (exchange study). All pigs received a 2% cholesterol diet for up to 6 months; then the transplanted aortic segments were analyzed. The donor normal aortic segments in the host normal pigs developed arteriosclerosis that involved an average of 20% of the surface; the endothelial fluorescent pattern of von Willebrand factor was identified. In contrast, the donor normal aortic segments in the host pigs with von Willebrand's disease had arteriosclerosis that involved an average of only 4% of the surface (P less than 0.01); the endothelial cell von Willebrand factor was not identified. The long-term prospective study indicates that pigs with von Willebrand's disease are resistant to the development of spontaneous arteriosclerosis. The aortic transplantation data are compatible with the hypothesis that the absence of von Willebrand factor in pigs with von Willebrand's disease may cause impairment of platelet-arterial wall interaction and resistance to arteriosclerosis.

“…% Fuster et al, 1978. inspected for lesions. Only one type of lesion was seen (Mitchell and Schwartz, 1965;Fritz et al, 1980;Griggs et al, 1981): a raised fibrous arteriosclerotic plaque consisting of a firm, gray, prominent elevation with predominantly collagen and elastic bundles, as detected microscopically. Quantification was done by recording the proportion of the aortic area affected.…”

Section: Postmortem Analysismentioning

confidence: 99%

“…In all of the studies, a distal aortic segment proximal to the trifurcation was chosen for transplantation because this region is most prone to the development of arteriosclerosis (Fritz et al, 1980;Griggs et al, 1981). The operation was done as follows: At 3 months of age, the 25 pigs underwent general anesthesia induced with ether and maintained with halothane.…”

Section: Operationmentioning

confidence: 99%

Arteriosclerosis in normal and von Willebrand pigs: long-term prospective study and aortic transplantation study.

Fass²,

et al. 1982

Circulation Research

View full text Add to dashboard Cite

In a long-term prospective study, five normal control pigs and five pigs with homozygous von Willebrand's disease received a nonfatty diet from age 3 months to 4 years; then the aortas were analyzed. The fibrous arteriosclerotic plaques in the distal abdominal aortic region involved an average of 28% of the surface area in control pigs and only 7% of the surface area in pigs with von Willebrand's disease (P less than 0.01). In a subsequent study of 3-month-old pigs, the distal abdominal aortic segments from nine normal pigs were cross-transplanted with segments from nine other normal pigs (control study), and aortic segments from four normal pigs were transplanted into four host pigs with von Willebrand's disease (exchange study). All pigs received a 2% cholesterol diet for up to 6 months; then the transplanted aortic segments were analyzed. The donor normal aortic segments in the host normal pigs developed arteriosclerosis that involved an average of 20% of the surface; the endothelial fluorescent pattern of von Willebrand factor was identified. In contrast, the donor normal aortic segments in the host pigs with von Willebrand's disease had arteriosclerosis that involved an average of only 4% of the surface (P less than 0.01); the endothelial cell von Willebrand factor was not identified. The long-term prospective study indicates that pigs with von Willebrand's disease are resistant to the development of spontaneous arteriosclerosis. The aortic transplantation data are compatible with the hypothesis that the absence of von Willebrand factor in pigs with von Willebrand's disease may cause impairment of platelet-arterial wall interaction and resistance to arteriosclerosis.

“…As shown in raised atherosclerotic lesions of swine aorta, the capacities for protein and DNA synthesis are increased about 10fold in comparison with normal media myocytes (14). As shown in raised atherosclerotic lesions of swine aorta, the capacities for protein and DNA synthesis are increased about 10fold in comparison with normal media myocytes (14).…”

Section: In-vitro Incubationsmentioning

confidence: 93%

“…Metabolic activity of the cells in the plaque can be estimated by their synthesis of DNA and protein in comparison with normal medical cells (14). Since it is known that within the proliferates produced by electrostimulation the mitotic activity of the smooth muscle cells is high (15), it is likely that the dividing cells in the plaque need an increased amount of oxydizable substrates.…”

Section: Introductionmentioning

confidence: 99%

Metabolic changes in modified smooth muscle cells of rabbit carotid arteries

¹

,

²

,

³

1982

Basic Res Cardiol

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In the common carotid artery of rabbits, intimal myocyte proliferations were induced by daily repeated local electrical stimulation of the vessel wall in combination with a cholesterol containing diet given for 4 weeks. Some biochemical parameters of the morphologically modified intimal smooth muscle cells were studied and compared with those of samples obtained from nonstimulated tunica media of the contralateral carotid artery. The results show that in relation to dry weight both alkali extractable protein and DNA content of the proliferates are increased to about 125%. In the proliferates, the in-vivo tissue concentrations of glucose and glycogen are only 50-70% of the normal values, whereas the concentration of lactate is increased to about 160%. In-vitro incubation experiments of excised tissues samples from the intimal proliferates and normal media indicate that under an optimal supply of substrates the glucose uptake and lactate production of the proliferates are increased to 140% and 150%, respectively. This results provides evidence for an increased capacity of glycolysis in the proliferates, which in vivo may lead to a decrease in glucose concentration and to an increased concentration of lactate. This investigation shows that modified smooth muscle cells proliferating in the arterial intima exhibit an activated metabolism as seen in other models of arteriosclerosis.

“…The use of the pig as a model animal in atherosclerosis research was reviewed by Vesselinovitch (1979). Studies have demonstrated that pigs develop lesions, both spontaneously (Gottlieb and Lalich, 1954; and in response to dietary manipulations (Bragdon et al, 1957;Rowsell et al, 1958Rowsell et al, , 1960Downie et al, 1963;Reitman et al, 1982), that are similar morphologically and bio chemically to those in humans (Fritz et al, 1980). Advanced atherosclerotic disease has been produced in swine by a combination of diet and endothelial injury (i.e.…”

Section: Introduction 1 Review Of Literaturementioning

confidence: 99%

Metabolism of cholesterol and triglycerides in young pigs fed beef-based, soy-based, or conventional diets

¹

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