Morphological analysis of the vertebral and basilar arteries in the Chinese population provides greater diagnostic accuracy of vertebrobasilar dolichoectasia and reveals gender differences

Deng, Dan; Cheng, Fu Bo; Zhang, Ying; Zhou, Hong; Feng, Yan; Feng, Jia

doi:10.1007/s00276-012-0960-9

Cited by 23 publications

(24 citation statements)

References 18 publications

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“…Diagnosis of VBD usually relies on assessment of the patient's vascular images by clinicians and radiologists based on their practical experience, in combination with clinical symptoms. A general consensus agrees that in VBD, the affected vertebrobasilar arteries are longer and broader than normal 6, 54.…”

Section: Imaging Featuresmentioning

confidence: 72%

Research Progress on Vertebrobasilar Dolichoectasia

Yuan¹,

Xu²,

Luo³

et al. 2014

Int. J. Med. Sci.

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Vertebrobasilar dolichoectasia (VBD) is a rare disease characterized by significant expansion, elongation, and tortuosity of the vertebrobasilar arteries. Current data regarding VBD are very limited. Here we systematically review VBD incidence, etiology, characteristics, clinical manifestations, treatment strategies, and prognosis. The exact incidence rate of VBD remains unclear, but is estimated to be 1.3% of the population. The occurrence of VBD is thought to be due to the cooperation of multiple factors, including congenital factors, infections and immune status, and degenerative diseases. The VBD clinical manifestations are complex with ischemic stroke as the most common, followed by progressive compression of cranial nerves and the brain stem, cerebral hemorrhage, and hydrocephalus. Treatment of VBD remains difficult. Currently, there are no precise and effective treatments, and available treatments mainly target the complications of VBD. With the development of stent technology, however, it may become an effective treatment for VBD.

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Section: Imaging Featuresmentioning

confidence: 72%

Research Progress on Vertebrobasilar Dolichoectasia

Yuan¹,

Xu²,

Luo³

et al. 2014

Int. J. Med. Sci.

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“…Currently, the diagnostic criteria for BADE used in China are derived from non-Asian populations 13 . Deng et al 12 previously proposed diagnostic criteria for BA ectasia for Chinese population; that is, males with a BA diameter >4.2 mm and females with a BA diameter >4.0 mm should be diagnosed with BA ectasia. The possible racial and gender differences in BA diameter may explain why there were so few patients with simple BA ectasia or BADE in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that the infarct sites of BADE patients are mainly in the pons, especially in the paramedian pontine 5,[9][10][11] . Furthermore, in Chinese population, few patients were diagnosed with BA ectasia or BADE based on the current diagnostic criteria for BADE 12,13 . But there are many cases with a simply elongated BA that cannot be classified as BADE.…”

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confidence: 99%

Basilar artery dolichosis is associated with a poor 90-day outcome in acute isolated pontine infarction

Cao

et al. 2020

Sci Rep

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Basilar artery (BA) dolichosis is not uncommon in patients with acute isolated pontine infarction. The effect of this abnormal BA geometrical form on the outcomes of pontine infarction has not been closely examined. This study aims to elucidate whether BA dolichosis contributes to a poor 90-day outcome in acute isolated pontine infarction. A total of 101 patients were enrolled with a median age of 65 years. the BA diameter (p = 0.026), basilar artery length (BAL) (p < 0.001), bending length (BL) (p < 0.001) and the proportion of BA bending (p < 0.001) were significantly higher in the BA dolichosis group. A poor outcome was closely associated with the baseline National Institute of Health Stroke Scale (NIHSS) score (p < 0.001), and BL (p = 0.042) as well as the proportions of BA dolichosis (p = 0.007) and BA bending (p = 0.010) in univariate analysis. Multivariate logistic regression analysis determined that BA dolichosis (adjusted oR = 4.724, 95% CI: 1.481~15.071, p = 0.009) and baseline NIHSS score (adjusted oR = 1.805, 95% CI: 1.296~2.513, p < 0.001) were independently associated with a poor outcome at 90 days. In conclusion, BA dolichosis may be a predictor of concern for a poor 90-day outcome in patients with acute isolated pontine infarction. ResultsClinical and demographic data of the study. In total, 131 patients with acute isolated pontine infarction were admitted during the study period between July 2015 and June 2018. Among these patients, 30 were excluded according to the exclusion criteria. There was no loss of follow-up or death during the 90-day follow-up. Therefore, 101 patients were finally enrolled in the present study (Fig. 1). All patients were Chinese Hans. Among the 101 patients, 60 (59.4%) were male and 41 (40.6%) were female with an age of 65 (20) (years, median (M) and interquartile range (IQR)). The infarct sites of 80 (79.2%) were located in the paramedian pontine area, 4 (4.0%) were in the anterior lateral pontine area, 9 (8.9%) were in the lateral pontine area and 8 (7.9%) were in multiple infarct areas. Patients with simple BA dolichosis accounted for 32.7% (33 cases), but no patients had simple BA ectasia. BADE patients accounted for only 1.0% (1 case). Of the 101 patients, 34 (33.7%) patients were divided into the BA dolichosis group, and the other 67 (66.3%) patients were divided into the non-BA dolichosis group. There were 81 (80.2%) patients with good outcomes versus 20 (19.8%) patients with a poor outcome at 90 days. The characteristics of the study population divided by group are summarized in Fig. 2 and Supplementary Table 1.

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“…Statistical differences in VA diameter between genders were not observed. However, Deng et al [9] reported the opposite relation for the Chinese population in which males exhibited a significantly wider arterial lumen compared to that of females.…”

Section: The Length and Diameter Of The Vmentioning

confidence: 97%

Intracranial region of the vertebral artery: morphometric study in the context of clinical usefulness

Dzierżanowski

Szarmach²,

Baścik³

et al. 2017

Folia Morphol

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The presented knowledge of anatomical variation and abnormali-ties of vertebral circulation can improve the accuracy and "safety" of the surgical procedures in this region, help to determine the range of surgical approach and avoid associated complications. The radiological examinations using 3D CT, DSA reveal unlimited observation of anatomical structures in contrast to studies based on cadavers, and can complement the morphometry in anatomical preparations.

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Morphological analysis of the vertebral and basilar arteries in the Chinese population provides greater diagnostic accuracy of vertebrobasilar dolichoectasia and reveals gender differences

Abstract: There are significant gender differences in the diameter of both the VA and BA, indicating that gender needs to be considered in the diagnosis of VBD. These results also provide much needed quantitative data for the diagnosis of VBD in Chinese people.

Cited by 23 publications

References 18 publications

Research Progress on Vertebrobasilar Dolichoectasia

Research Progress on Vertebrobasilar Dolichoectasia

Basilar artery dolichosis is associated with a poor 90-day outcome in acute isolated pontine infarction

Intracranial region of the vertebral artery: morphometric study in the context of clinical usefulness

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