Morphological analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan®) and methylprednisolone acetate (Depomedrol®) in osteoarthritis

Ronchetti, Ivonne Pasquali; Guerra, Deanna; Taparelli, F.; Boraldi, F.; Bergamini, Giuseppe; Mori, G.; Zizzi, F; Frizziero, L

doi:10.1093/rheumatology/40.2.158

Cited by 88 publications

(39 citation statements)

References 30 publications

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“…Results from experimental OA and limited arthroscopic observations in humans indicate that hyaluronan possesses mild chondroprotective and anti-inflammatory activities. [37][38][39] Compared with hyaluronan, intra-articularly administered GlcNAc in normal saline has a much shorter half life (minutes for GlcNAc versus hours for hyaluronan (San-Bao Hwang, unpublished data)). However, in experimental OA GlcNAc demonstrated better disease modifying activity than hyaluronan.…”

Section: Discussionmentioning

confidence: 99%

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

Shikhman

2005

Annals of the Rheumatic Diseases

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Objective: To examine the therapeutic efficacy of N-acetylglucosamine (GlcNAc) in rabbits with experimental osteoarthritis (OA). Methods: Experimental OA was induced in rabbits by anterior cruciate ligament transection (ACLT). In the first study, rabbits (six in each group) received intramuscular injections of GlcNAc or normal saline three times a week starting 1 week postoperatively. In the second study, rabbits (eight in each group) were injected intra-articularly with GlcNAc (either once or twice a week) or normal saline. In the third study, rabbits (seven in each group) were injected intra-articularly twice a week with either GlcNAc, hyaluronan, or normal saline. Animals were killed 8 weeks after ACLT for macroscopic and histological assessment of the knee joints. Results: Intramuscular administration of GlcNAc in rabbits with experimental knee OA did not show chondroprotective effects but showed mild anti-inflammatory activity. In contrast, intra-articular administration of GlcNAc twice a week reduced cartilage degradation. Additionally, intra-articular GlcNAc also suppressed synovitis. Once a week intra-articular injections of GlcNAc did not demonstrate therapeutic efficacy. The chondroprotective efficacy of GlcNAc was better than that of viscosupplementation treatment with hyaluronan. Conclusion: Intra-articular GlcNAc has chondroprotective and anti-inflammatory activity in experimental OA.

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Section: Discussionmentioning

confidence: 99%

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

Shikhman

2005

Annals of the Rheumatic Diseases

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“…Hyaluronic acid concentrations are decreased in the joints of patients with osteoarthritis. [17][18][19][20] Hyaluronic acid is responsible for the viscoelastic component of synovial joint fluid; it is also an effective lubricant, shock absorber, and fluid retainer, especially in weightbearing joints. 21 The exact mechanism through which intra-articular hyaluronic acid promotes decreased joint pain is not clearly understood, but there are numerous proposed mechanisms including upregulation of cartilage synthesis as well as the inhibition of inflammatory cytokines and phagocytic cells.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

“…27 It has also been suggested that low-to mid-weight hyaluronic acid concentrations have better penetration into synovial tissue and may contain some disease-modifying activity, though these benefits have not been demonstrated in clinical studies. 19,22 …”

Section: Hyaluronic Acidmentioning

confidence: 99%

The Efficacy of Hyaluronic Acid in the Treatment of Osteoarthritis of the Trapeziometacarpal Joint

Moran¹,

Duymaz²,

Karabekmez³

2009

The Journal of Hand Surgery

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“…vide further evidence that HA injections may be an effective low-risk treatment for TMCJ OA unresponsive to standard medical therapy 4,[11][12][13] . This retrospective open label study evaluated the results of i.a.…”

Section: Six-months Pain Relief and Functional Recovery After Intra-amentioning

confidence: 89%

Six-months pain relief and funcional recovery after intra-articular injections with hyaluronic acid (mw 500-730 kda) in trapeziometacarpal osteoarthritis

Frizziero

Maffulli

Masiero

et al. 2014

MLTJ

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SummaryBackground: this retrospective open label study evaluates the efficacy and tolerability of intra-articular injections of Hyaluronic Acid (HA) (MW 500-730 KDa -Hyalgan®) for the treatment of pain and disability of trapeziometacarpal joint osteoarthritis (TMCJ OA). Methods: fifty eight patients, 50 females (86%) and 8 male (14%), aged between 40-75 years, suffering from TMCJ OA according to Kellgren-Laurence grades 2-3 on standard plain radiography, were included. Patients with known inflammatory arthritis, previous thumb trauma and intra-articular (i.a.) injections with corticosteroids were excluded. Primary endpoints were: pain (VAS), NSAID intake, radial and palmar ab-/adduction, pinch strength. All patients received an i.a. injection of 0.8 mL of HA (MW 500-730 KDa) once weekly for three weeks. Control examinations were carried out at 1, 3, and 6 months. Results: intra-articular HA injections have significantly reduced spontaneous and provoked pain

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Morphological analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan®) and methylprednisolone acetate (Depomedrol®) in osteoarthritis

Cited by 88 publications

References 30 publications

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

The Efficacy of Hyaluronic Acid in the Treatment of Osteoarthritis of the Trapeziometacarpal Joint

Six-months pain relief and funcional recovery after intra-articular injections with hyaluronic acid (mw 500-730 kda) in trapeziometacarpal osteoarthritis

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