Morphological analysis of fibrous webs electrospun from Polycaprolactone, polylactic acid and their blends in chloroform based solvent systems

Optimization of Electrospun Bilayer Vascular Grafts through Assessment of the Mechanical Properties of Monolayers

“…It is known that the higher molecular weight results in an increase in the solution viscosity, which causes the fiber diameters to get larger in the electrospinning process. 22,45,46 The oriented samples produced at higher rotational speeds have higher fiber diameters in nearly all sample groups, which can be attributed to the increase in applied voltage in the samples produced by higher rotational speeds. Normally, it is expected that the samples produced by higher rotational speeds will have lower fiber diameters than the ones produced by using slower collector speeds because the fibers are subjected to stretching force.…”

“…When the fiber diameters of the blended samples are assessed, the fiber diameters are increased with the addition of PLA because it has a higher molecular weight ( M n 230,000) than the PCL polymer ( M n 80,000) that is used in the production process. It is known that the higher molecular weight results in an increase in the solution viscosity, which causes the fiber diameters to get larger in the electrospinning process. ,, …”

“…For the process of manufacturing the tubular scaffolds with randomly distributed and radially oriented fibers, PCL, PLA, and PLCL polymers are all dissolved in CHL/ETH/AA (8/1/1 wt) which has been optimized in preliminary studies. ,,, PCL and PLA solutions are prepared in neat or blended forms, whereas PLCL is used in the neat form. By varying the blending ratio (90/10, 80/20, 70/30, 60/40, and 50/50) by increasing 10 in the range of 50–100%, optimum blend ratios that will eliminate the individual deficiencies of each polymer are determined. , The polymer concentration for the solutions made of both pure PCL and PLA and their blends is determined as 8% wt. , while PLCL solution is prepared at 10% wt .…”

Functionalization of PLA nanofibers with PCL blending and TiO2 nanoparticle addition

“…For example, Eren et al [24] investigated the production of electrospun PLA and PLA/PCL fibers, incorporating ampicillin trihydrate for drug delivery. Oztemur et al [30] developed PLA/PCL webs for tissue-engineering applications, such as vascular grafts, using several chloroform-based solvent solutions. By varying the polymer mass ratios, Goreninskii et al [31] investigated the effect of single-channel and multi-channel electrospinning on the properties of the manufactured PLA/PCL scaffolds.…”

“…TiO 2 nanoparticles have significant interest due to their self-cleaning, low cost, and antibacterial characteristics. They are also highly adaptable to a wide range of applications, including but not limited to solar cells and tissue engineering [5,30,[41][42][43][44]. Their effectiveness is contingent upon the size, shape, phase, and physical characteristics of the individual particles within the matrix or on the surface of the materials [45].…”