Morphological alteration of seminiferous tubules of testes of Wistar rat offspring exposed to alcohol during pregnancy and/or lactation

Onu, JE; Oke, B. O.; Ozegbe, PC; Oyewale, JO

doi:10.4314/ijbcs.v8i1.1

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…In the present study, we observed reductions of the gonadosomatic index and the diameter of seminiferous tubules. These results are consistent with findings in rat offspring that were exposed to ethanol during pregnancy or lactation (Onu, Oke, Ozegbe, & Oyewale, 2014). Interestingly, these morphological alterations were not accompanied by alterations of testosterone levels, which could be attributable to the increase in the number of Leydig cells in ethanol mice.…”

Section: Discussionsupporting

confidence: 92%

Ethanol exposure during the brain growth spurt period increases ethanol‐induced aggressive behavior in adolescent male mice

Demarque

Krahe

Oliveira

et al. 2020

Intl J of Devlp Neuroscience

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Ethanol exposure during development is associated with deficient social behavior, such as aggressive behavior, and ethanol consumption is associated with violent crimes, thus raising the possibility that individuals with fetal alcohol spectrum disorder may exhibit exacerbated social deficits in response to ethanol exposure. The present study evaluated the effects of ethanol exposure during the brain growth spurt period (i.e., a critical time period during which ethanol's effects are augmented) on aggressive behavior and ethanol‐induced aggression during adolescence. From postnatal Day 2 (PD2) to PD8, Swiss mice received either ethanol (5 g/kg, i.p.) or saline on alternate days. On PD39, aggressive behavior was assessed using the resident‐intruder paradigm in male mice, and social dominance was investigated using the tube dominance test in both males and females. Testis structure and testosterone levels were evaluated in male mice. Early ethanol exposure increased the gonadosomatic index and the number of Leydig cells. The thickness of the seminiferous tube decreased. No difference in testosterone levels was found. The ethanol‐exposed resident mice exhibited increased number and duration of aggressive episodes only when challenged with a low ethanol dose (1 g/kg) before confrontation. Female mice early‐exposed to ethanol won more confrontations in the tube dominance test. The present findings suggest a critical brain growth spurt period that is susceptible to ethanol‐induced alterations of social dominance behavior in females. Although basal levels of aggression were unaffected, early ethanol exposure resulted in greater susceptibility to ethanol‐induced aggression in adolescent male mice.

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Section: Discussionsupporting

confidence: 92%

Ethanol exposure during the brain growth spurt period increases ethanol‐induced aggressive behavior in adolescent male mice

Demarque

Krahe

Oliveira

et al. 2020

Intl J of Devlp Neuroscience

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show abstract

“…Alcohol consumption during pregnancy is associated with fetal alcohol syndrome (FAS) [1]. FAS is characterized by restricted fetal growth and dysfunction of the nervous system [2][3][4]. The consequence of ethanol present in the prenatal environment is associated with long-term consequences such as enduring growth retardation [5].…”

Section: Introductionmentioning

confidence: 99%

Tamarindus Indica Improved Growth Retardation Associated With Prenatal Ethanol Exposure in Wistar Rat Neonates

Usman,

Archibong,

Etukudo

et al. 2021

KJHS

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Background: Complications associated with alcoholism such as enduring growth retardation, especially during pregnancy, are serious health issues calling for lots of attention. Objectives: The study evaluated the effect of Tamarindus indica during prenatal ethanol (ET) exposure on pregnancy outcome and morphometric features of Wistar rat pups. Methodology: Twenty-four (24) pregnant timed Wistar rats were randomly assigned into 6 groups (n=4); Group A received 2 ml (distilled water), Groups B and C were administered 200 mg/kg ethanol extract of Tamarindus indica pulp (EETI), and 300 mg/kg of Vitamin E respectively, Group D received 30%v/v (2 mg/kg) of ET, Group E received 30%v/v (2 mg/kg) of ET + 200 mg/kg EETI, while Group F was administered 30%v/v (2 mg/kg) of ET + 300 mg/kg of Vitamin E. All administrations were via the oral route and lasted for 7 days from prenatal day 7 to 14. On postnatal day (PoND) zero, physical observations were made and the total number of littered pups was counted. Morphometric studies involved the measurements of the crown-rump length (CRL), fore-limb length (FL), hind-limb length (HL), tail length (TL), and body weight (BW) of pups were made using digital vernier caliper and analytical balance. Result: Prenatal ET exposure interfered with the pregnancy outcome, CRL, FL, HL, TL, and BW measurement; while treatment with EETI and vitamin E was associated with marked improvement. Conclusion: The administration of EETI during prenatal ethanol exposure was associated with significant improvements CRL, FL, HL, TL, and BW pups. Therefore, more attention should be given to the important medicinal plant that could possibly reduce pregnancy complications associated with prenatal ethanol exposure.

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Histological and biochemical studies of Tamarindus indica pulp extract on the cerebral cortex in prenatal ethanol exposure in Wistar rats

Usman¹,

Buraimoh²,

Ibegbu³

2016

J Exp Clin Anat

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Morphological alteration of seminiferous tubules of testes of Wistar rat offspring exposed to alcohol during pregnancy and/or lactation

Cited by 3 publications

References 12 publications

Ethanol exposure during the brain growth spurt period increases ethanol‐induced aggressive behavior in adolescent male mice

Ethanol exposure during the brain growth spurt period increases ethanol‐induced aggressive behavior in adolescent male mice

Tamarindus Indica Improved Growth Retardation Associated With Prenatal Ethanol Exposure in Wistar Rat Neonates

Histological and biochemical studies of Tamarindus indica pulp extract on the cerebral cortex in prenatal ethanol exposure in Wistar rats

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