Morphologic variability of human chromosomes: Polymorphism of constitutive heterochromatin

Ghosh, Pradeep; Singh, Ishwar

doi:10.1007/bf00291498

Cited by 12 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous reports have called attention t o the location of minor variants within heterochromatin (known t o contain highly reiterated sequences o f DNA), adjacent t o the centromeres, and in the distal part of the Y chromosome [ l , 31 . The staining characteristics of these minor chromosome variants and their occurrence in normal individuals suggest that they may represent benign polymorphisms of constitutive heterochromatin [4] . However, the interspecies conservation of DNA base composition in a proportion of heterochromatin from lower animals indicates an important function of at least some constitutive heterochromatin [ S ] .…”

Section: Introductionmentioning

confidence: 99%

Minor chromosome variants in child psychiatric patients

et al. 1978

View full text Add to dashboard Cite

The frequency of minor chromosome variants, as detected by conventional chromosome analysis, was examined among 1,289 child psychiatric patients, of whom one-fourth had only behavioral problems and three-fourths had congenital abnormalities and more severe mental disorders. There was no more than random association between prominent satellites, prominent secondary constrictions or a long Y chromosome, and congenital abnormalities or more severe mental disorders. The frequencies of these chromosome variants were affected by race as has been shown in previous studies. These findings do not support the evidence for a developmental effect of minor variants in man.

show abstract

Section: Introductionmentioning

confidence: 99%

Minor chromosome variants in child psychiatric patients

et al. 1978

View full text Add to dashboard Cite

show abstract

Heterogeneity of human chromosome 9 constitutive heterochromatin as revealed by sequential distamycin A/DAPI staining and C-banding

et al. 1981

View full text Add to dashboard Cite

Distamycin A/DAPI staining and sequential C-banding of human lymphocyte chromosomes reveals the regular occurrence of differentially staining subfractions of chromosome 9 constitutive heterochromatin. These subfractions are regionally organized as two subsegments: a distal one, which fluoresces brightly with DAPI after preincubation with distamycin A and a proximal one, which stains intensely with Giemsa after sequential C-banding. Observations are presented that indicate an occasionally independent genetic behavior of these heterochromatin subfractions.

show abstract