Morphologic three-dimensional scanning of fallopian tubes to assist ovarian cancer diagnosis

Madore, Wendy‐Julie; Montigny, Etienne De; Deschênes, Andréanne; Benboujja, Fouzi; Leduc, M; Mes-Masson, Anne-Marie; Provencher, Diane; Rahimi, Kurosh; Boudoux, Caroline; Godbout, Nicolas

doi:10.1117/1.jbo.22.7.076012

Cited by 11 publications

(7 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Keenan et al provided B‐scan images using an OCT falloposcope imaging porcine fallopian tubes, presumably benign . Madore et al showed B‐scan images of a fresh excised healthy human fallopian tube . These studies focus on proving the feasibility of falloposcope and providing qualitative OCT images.…”

Section: Discussionmentioning

confidence: 99%

Histogram analysis of en face scattering coefficient map predicts malignancy in human ovarian tissue

Zeng

Nandy

Rao

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

Ovarian cancer is a heterogeneous disease at the molecular and histologic level. Optical coherence tomography (OCT) is able to map ovarian tissue optical properties and heterogeneity, which has been proposed as a feature to aid in diagnosis of ovarian cancer.In this manuscript, depth-resolved en face scattering maps of malignant ovaries, benign ovaries, and benign fallopian tubes obtained from 20 patients are provided to visualize the heterogeneity of ovarian tissues. Six features are extracted from histograms of scattering maps. All features are able to statistically distinguish benign from malignant ovaries. Two prediction models were constructed based on these features: a logistic regression model (LR) and a support vector machine (SVM). The optimal set of features is mean scattering coefficient and scattering map entropy. The LR achieved a sensitivity and specificity of 97.0% and 97.8%, and SVM demonstrated a sensitivity and specificity of 99.6% and 96.4%. Our initial results demonstrate the feasibility of using OCT as an "optical biopsy tool" for detecting the microscopic scattering changes associated with neoplasia in human ovarian tissue. K E Y W O R D Scancer prediction, optical coherence tomography, ovarian cancer, scattering coefficient map

show abstract

Section: Discussionmentioning

confidence: 99%

Histogram analysis of en face scattering coefficient map predicts malignancy in human ovarian tissue

Zeng

Nandy

Rao

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

show abstract

“…Therefore, there is a major effort toward the development of in vivo oviduct screening methods. Fiber‐based OCT probes guided through the fallopian tube (falloposcopes) are currently being developed for the ovarian cancer diagnostics and screening (Keenan et al, 2017; Madore et al, 2017). If this trend continues, OCT fiber‐based falloposcopes are expected to enter clinical trials within a few years, and have a chance to become a standard clinical practice for ovarian cancer screening within the fallopian tube.…”

Section: Oocyte/embryo Transport and Early Embryo Developmentmentioning

confidence: 99%

Optical coherence tomography for dynamic investigation of mammalian reproductive processes

Umezu

Larina

2022

Molecular Reproduction Devel

View full text Add to dashboard Cite

The biological events associated with mammalian reproductive processes are highly dynamic and tightly regulated by molecular, genetic, and biomechanical factors.Implementation of live imaging in reproductive research is vital for the advancement of our understanding of normal reproductive physiology and for improving the management of reproductive disorders. Optical coherence tomography (OCT) is emerging as a promising tool for dynamic volumetric imaging of various reproductive processes in mice and other animal models. In this review, we summarize recent studies employing OCT-based approaches toward the investigation of reproductive processes in both, males and females. We describe how OCT can be applied to study structural features of the male reproductive system and sperm transport through the male reproductive tract. We review OCT applications for in vitro and dynamic in vivo imaging of the female reproductive system, staging and tracking of oocytes and embryos, and investigations of the oocyte/embryo transport through the oviduct.We describe how the functional OCT approach can be applied to the analysis of cilia dynamics within the male and female reproductive systems. We also discuss the areas of research, where OCT could find potential applications to progress our understanding of normal reproductive physiology and reproductive disorders.

show abstract

“…Fluorescence spectroscopy/imaging provides information on tissue composition, metabolism and/or targeted contrast agents. Autofluorescence imaging can detect serous-origin precancerous and cancerous lesions in ex vivo FT and ovaries with good sensitivity and specificity 13 and multispectral fluorescence imaging (MFI) can differentiate healthy, benign, and malignant ovarian and FT tissue 14 , Optical coherence tomography (OCT) reveals subsurface microstructural information and can distinguish normal and cancerous structure in ovaries and FT [15][16][17][18] . Because fluorescence techniques provide functional information whereas OCT provides microstructural information, they are potentially synergistic modalities.…”

Section: Introductionmentioning

confidence: 99%

Iterative prototyping based on lessons learned from the falloposcope in vivo pilot study experience

Rocha

Drake²,

Rice³

et al. 2023

Endoscopic Microscopy XVIII

View full text Add to dashboard Cite

High grade serous ovarian cancer is the most deadly gynecological cancer, and it is now believed that most originate in the fallopian tubes (FTs). We developed a FT endoscope, the falloposcope, as a method for detecting ovarian cancer. The falloposcope clinical prototype is being implemented in a pilot study with 20 volunteers (12 enrolled to date) to evaluate the safety and feasibility of FT imaging prior to standard of care salpingectomy in normal-risk volunteers. The falloposcope is approximately 0.8 mm in diameter and is introduced via a minimally invasive approach through a commercially available hysteroscope and introducing catheter. To date, FT navigation video, multispectral reflectance and fluorescence images, and optical coherence tomography (OCT) of human FT have successfully been acquired. This manuscript describes the fabrication improvements and iterative design changes that have been introduced to improve usability and reduce failure points based on clinical implementation. We discuss falloposcope improvements made with respect to the following subjects: improving perceived image quality with the fiber bundle, GRIN lens stray light, and improving the proximal imaging system. Navigation and MFI are limited by the 3,000 element fiber bundle and lens working distance (WD). A future system is being developed with a 10,000 element fiber bundle, more uniform illumination, a closer WD lens, and wire cytology instead of OCT probe.

show abstract

Morphologic three-dimensional scanning of fallopian tubes to assist ovarian cancer diagnosis

Cited by 11 publications

References 54 publications

Histogram analysis of en face scattering coefficient map predicts malignancy in human ovarian tissue

Histogram analysis of en face scattering coefficient map predicts malignancy in human ovarian tissue

Optical coherence tomography for dynamic investigation of mammalian reproductive processes

Iterative prototyping based on lessons learned from the falloposcope in vivo pilot study experience

Contact Info

Product

Resources

About