Morphologic studies of the liver cell dysplasia

Abstract

Light and electron microscopic changes in human liver cells which were considered to be precancerous lesions, were studied. In our micrometrical examination, dysplastic liver cells were classified into two types: large and small dysplastic cell. Each type had nuclear pleomorphism and multinucleation; however, the nucleocytoplasmic ratio of the large dysplastic cell remained normal. Electron microscopically, the large dysplastic cell had some features of regenerative cells. The nucleocytoplasmic ratio of the small dysplastic cell was between that of normal hepatocytes and liver cancer cells. The difference in the incidence of the small and large dysplastic cells in normal livers and cirrhotic livers having hepatocellular carcinoma was statistically significant. In addition, the small dysplastic cell had more of a tendency to produce a small round focus. It was morphologically suggested that the more important candidate for the precancerous cell in the liver was the small dysplastic cell.

Clonal analysis of macronodules in cirrhosis

“…Several authors argue that among them, SLCC should be considered as one of the major preneoplastic pathological criteria. 33,34 It is of note that in the present work, among the 7 macronodules displaying SLCC, only 3 showed a monoclonal pattern. Although the procedure we used is very sensitive, After HpaII digestion, control monoclonal DNA displays only one peak.…”

Pathologic diagnosis of early hepatocellular carcinoma: A report of the international consensus group for hepatocellular neoplasia

“…3). Small cell change (also known as small cell dysplasia 30 ) is the most frequently seen form of cytologic atypia in HDNs. This form of atypia may also occur in small hepatocellular foci outside of H-DNs; the term dysplastic focus 11 may be appropriately used for such lesions.…”

Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

“…1). Dysplastic lesions were defined as cirrhotic nodules in which hepatocytes showed enlarged pleomorphic nuclei and included both large and small cell types (22). Dysplastic hepatocytes were present in the form of atypical cirrhotic nodules that were large and often poorly demarcated.…”