Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates

Scott, Lynette; Finn, A.; O’Leary, Thomas; McLellan, S.; Hill, Joseph A.

doi:10.1093/humrep/del358

Cited by 153 publications

(115 citation statements)

References 46 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…However, the correlation between 1 PB morphology and implantation and pregnancy rate found in our study is a controversial issue in the literature. Only few published reports have examined the association between 1 PB morphology, implantation rate [5,6,8,11,13] and pregnancy rate [5,12,13]. Our results are in accordance with some of the previously published reports [5,6] however, they contradict other reports [8][9][10][11]13].…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, there is a large discrepancy in the literature concerning the timing of 1 PB morphology evaluation ranging from 2 to 11 h following retrieval [4][5][6][7][8][9][10][11][12][13]. As has already has been explained this might have a crucial effect on 1 PB morphology.…”

Section: Discussionmentioning

confidence: 99%

“…A large 1 PB would indicate a problem with check point genes and mitogen activated protein Kinase, cMOS and involving first meiotic spindle establishment [19]. In addition, few of these studies included only "good quality" infertile women [11,13] while others defined poor responders as those having below 10 oocytes per retrieval [8]. As well, few studies estimated only a selected number of oocytes from each retrieved infertile woman [9,13].…”

Section: Discussionmentioning

confidence: 99%

“…Part of these studies has shown a correlation between the 1 PB morphology and oocyte performance during ICSI treatment [4][5][6]12] while others did not [8,9,11,13]. Moreover, the grounds for this discrepancy between the studies are still not clear.…”

Section: Introductionmentioning

confidence: 99%

“…Several investigators have questioned whether normal development of the 1 PB morphology is correlated to fertilization rate [4][5][6][7][8][9][10][11], cleavage rate [4,7,10], embryo quality [4][5][6][7][8][9][10][11][12][13], blastocyst formation [8,12] as well as implantation [5,8,[10][11][12][13] and pregnancy rates [5,6,10,13].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Does first polar body morphology predict oocyte performance during ICSI treatment?

Younis

Radin

Izhaki

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To gain insight into the morphology of the first polar body (1 PB) in ICSI patients and to explore whether it could predict mature oocyte viability and performance in this setting. Methods Seventy two consecutive women planned to perform ICSI treatment were prospectively recruited for this study. All oocytes retrieved underwent evaluation for nuclear maturity and accurate assessment of 1 PB morphology. MII oocytes were cultured in separate groups in each woman in accordance with two different categories of 1 PB morphology. Category A included normal intact round or ovoid 1 PB and category B included abnormal fragmented 1 PB. Each oocyte was followed throughout fertilization, embryo cleavage and embryo transfer. Cycles that reached embryo transfer, were divided into three groups in accordance with 1 PB morphology. Group I included only category A 1 PB embryos, group II included categories A and B 1 PB embryos, whereas group III included only category B 1 PB embryos. Results A total of 687 oocytes were aspirated and 553 MII oocytes underwent ICSI leading to 410 zygotes showing normal fertilization on day one. Three hundred ninety seven embryos cleaved on day two and a total of 176 embryos were replaced into the uterus. Clinical implantation and pregnancy rates were significantly correlated with the morphology of the 1 PB corresponding to 31%, 9% and 2% and 61%, 24% and 5%, in groups I, II and III respectively. Conclusions Our findings demonstrate that 1 PB morphology is related to mature oocyte viability and it has the potential to predict oocyte performance and pregnancy achievement in infertile women undergoing ICSI treatment.

show abstract