Morphologic evidence that analgesic-induced kidney pathology contributes to the progression of tumors of the renal pelvis

Stewart, John H.; Hobbs, J. B.; McCredie, Margaret

doi:10.1002/(sici)1097-0142(19991015)86:8<1576::aid-cncr27>3.0.co;2-v

Cited by 41 publications

(23 citation statements)

References 23 publications

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“…Other environmental risk factors unique to the upper urothelial tract, such as analgesic nephropathy (3,4) and Balkan nephropathy (5, 6), have been identified, and recent reports point to polluted artesian well water (41) and Chinese herbs (42) as causative agents. Comparatively little is known about genetic predispositions in urothelial cancers (43).…”

Section: Discussionmentioning

confidence: 99%

“…Similar to bladder carcinoma, smoking and occupational exposure to arylamines are well-established risk factors for upper tract urothelial carcinoma accounting for the majority of cases (2). There are also unusual exogenous carcinogenic factors unique to the upper urothelial tract, including analgesic nephropathy (3,4) and Balkan nephropathy (5,6). The 5-year cancer-specific survival for upper tract urothelial carcinoma in the United States approaches 75%, and stage and grade are the most powerful predictors of survival (1).…”

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confidence: 99%

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Upper Tract Urothelial Carcinoma: A Clinicopathologic Study Including Microsatellite Instability Analysis

et al. 2002

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Urothelial carcinoma of the renal pelvis and ureter may develop as a manifestation of the hereditary nonpolyposis colorectal cancer syndrome that is characterized by mutations in a number of DNA mismatch repair genes and detectable as microsatellite instability. In this study, we examined microsatellite instability and the clinicopathologic features of urothelial carcinoma of the renal pelvis (n ‫؍‬ 61) and ureter (n ‫؍‬ 53) from 114 consecutive patients surgically treated from 1985-1992. Clinical data were obtained through chart review. Matched normal and tumor DNA was extracted from paraffin-embedded tissue, and a panel of six microsatellite loci was analyzed. The male-female ratio was 2.8:1 with a median age of 70 years (range, 28 to 92 y). Microsatellite analysis was successful in 67 tumors, and 21 (31.3%) patients had tumors that exhibited microsatellite instability. Patients with microsatellite-unstable tumors were significantly more likely to have additional nonurologic cancers (P ‫؍‬ .015) including colorectal carcinoma (P ‫؍‬ .001) compared with patients with tumors that did not exhibit microsatellite instability. In addition, patients with microsatellite-unstable tumors showed more colorectal cancers in their family (P ‫؍‬ .026) and were more likely to have higher grade urothelial carcinoma of the upper tract (P ‫؍‬ .028). Grade and stage, but not microsatellite status, were the strongest predictors of cancer-specific survival. This study found the highest frequency of microsatellite instability in upper urothelial tract carcinomas reported to date and highlights upper tract urothelial carcinoma as a marker of the hereditary nonpolyposis colorectal cancer syndrome in some patients. These findings reinforce the importance of obtaining cancer histories in patients with upper tract urothelial carcinoma to subsequently identify individuals with the hereditary nonpolyposis colorectal cancer syndrome and at-risk relatives for surveillance and management programs.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Upper Tract Urothelial Carcinoma: A Clinicopathologic Study Including Microsatellite Instability Analysis

et al. 2002

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“…This could promote carcinogenesis or act as a cofactor in the presence of chronic irritation, infection or smoking. 25 The use of phenacetin was progressively abandoned in the 1980s and replaced by acetaminophen, which does not increase the cancer risk. …”

Section: Analgesicsmentioning

confidence: 99%

Epidemiology of urothelial carcinoma

2017

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The epithelium lining is defined as the mucosal surfaces of the renal collecting tubules, calyces and pelvis, as well as the ureter, bladder and urethra. The term "urothelium" is used to refer to these surfaces. Upper tract urothelial carcinoma is a rare subset of urothelial cancers with a poor prognosis. Urinary bladder cancer is the most common malignancy involving the urinary system. Upper tract urothelial carcinoma is more common in men than in women, with a male-to-female ratio of 2:1. The incidence of urinary bladder cancer is also higher in men. Cigarette smoking and occupational exposure are the main upper tract urothelial carcinoma and urinary bladder cancer risk factors, while other factors are more specific to the carcinogenesis of upper tract urothelial carcinoma (i.e. Balkan endemic nephropathy, Chinese herb nephropathy). In Egypt until recent years, urinary bladder cancer was the most frequently diagnosed cancer due to Schistosoma haematobium. Substantial knowledge exists regarding the causes of upper tract urothelial carcinoma and urinary bladder cancer, and epidemiological studies have identified various chemical carcinogens that are believed to be responsible for most cases of urothelial carcinoma. In the era of precision medicine, genetic effects might play a direct role in the initiation and progression of urothelial carcinoma.

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“…[1] Rare upper urothelial malignancies can be associated with renal stone disease or hydronephrosis [2][3][4] probably associated with a chronic inflammation or infection or with analgesic abuse. [5] In our cases, the malignancy was detected postoperatively during histopathological examination of nephrectomized specimen. We report two cases for rarity of their location (renal pelvis) and their coexistence with xanthogranulomatous pyelonephritis.…”

Section: Introductionmentioning

confidence: 65%

Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: Report of two cases

2010

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Squamous cell carcinoma of urinary tract is a rarely encountered tumor. It is more frequently reported in urinary bladder and male urethra than renal pelvis. Squamous cell carcinoma of renal pelvis is usually associated with nephrolithiasis. However, coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis is exceedingly rare with only one case on record so far. We report two such cases detected incidentally in patients who have undergone nephrectomy for hydronephrosis. The post operative histological evaluation revealed unsuspected squamous cell carcinoma of renal pelvis with concomitant xanthogranulomatous pyelonephritis.

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Morphologic evidence that analgesic-induced kidney pathology contributes to the progression of tumors of the renal pelvis

Cited by 41 publications

References 23 publications

Upper Tract Urothelial Carcinoma: A Clinicopathologic Study Including Microsatellite Instability Analysis

Upper Tract Urothelial Carcinoma: A Clinicopathologic Study Including Microsatellite Instability Analysis

Epidemiology of urothelial carcinoma

Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: Report of two cases

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