Morphologic diversity of the endometrial gastrointestinal-type adenocarcinoma

Karpathiou, Georgia; Chauleur, Céline; Mathonat, Laure; Dridi, Maroa; Picot, Tiphanie; Devouassoux‐Shisheboran, Mojgan; Péoc’h, Michel

doi:10.1016/j.prp.2022.153759

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…To conclude, the present report described a rare case of intestinal-type mucinous carcinoma of the endometrium, which showed a polypoidal exophytic form. According to a number of previous reports (2,5,6), endometrial intestinal-type carcinoma appears to have a dismal prognosis compared with that of classical mucinous Müllerian type carcinomas of the endometrium (5,6). The present case did not present with any myometrial invasion or extramural extension due to its polypoidal exophytic form, which may have contributed to its favorable prognosis.…”

Section: Discussionsupporting

confidence: 45%

“…This rare tumor may be misdiagnosed as Müllerian-type endometrial mucinous carcinoma, endocervical adenocarcinoma, metastasis of a gastro-intestinal tract adenocarcinoma or gastric (gastro-intestinal) type mucinous metaplasia (5). The presence of mucin production in both non-neoplastic and neoplastic endometrium is common (6). Therefore, Müllerian-type endometrial mucinous carcinoma should be distinguished from endometrial intestinal-type carcinoma (5).…”

Section: Discussionmentioning

confidence: 99%

“…Medical history of extra-uterine carcinoma is key for diagnosis of metastasis from another organ (12). Furthermore, the WHO classification proposed a method for differentiating between primary endometrial carcinoma and metastatic carcinoma (6). It specifically states that metastatic tumors demonstrate 'widespread replacement of endometrial stroma while sparing benign endometrial glands, along with the disproportional involvement of serosa or outer myometrium' (5).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this rare histological type should be diagnosed correctly according to the diagnostic criteria described by Wong et al (2). Apart from the four cases described by Wong et al (2), there have been only 11 cases in the literature reporting the features of this endometrial intestinal-type mucinous carcinoma after the establishment of its definitive classification (5), where the findings remained ambiguous (6). Therefore, further studies, including case reports, are necessary to deepen the understanding of this rare histological subtype.…”

Section: Introductionmentioning

confidence: 98%

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Intestinal‑type mucinous carcinoma of the endometrium showing a polypoidal exophytic form: A case report

Nakano,

Fukuda,

Tanaka

et al. 2023

Oncol Lett

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Although endometrial cancer is a common malignancy in women, rare histological subtypes can pose diagnostic challenges. Primary endometrial intestinal-type mucinous carcinoma is a newly recognized subtype of endometrial cancer that differs from Müllerian-type endometrial mucinous carcinoma. The present case report documents a rare case of intestinal-type mucinous carcinoma of the endometrium showing a polypoidal exophytic form. The patient, an 80-year-old female, was incidentally diagnosed with a uterine tumor during a follow-up for vulvar Paget's disease. Clinical and imaging examinations revealed a localized mass within the uterine cavity. Hysteroscopy and subsequent histological examination confirmed the presence of intestinal-type mucinous carcinoma of the endometrium. Microscopically, the tumor displayed adenocarcinoma containing an intestinal-type glandular epithelium with mild nuclear atypia. It stained positive for the gastrointestinal markers mucin 2 and caudal type homeobox 2, and stained negatively for estrogen receptor α. The patient underwent surgery and adjuvant chemotherapy, with no evidence of recurrence at the latest follow-up 6 months after surgery. Endometrial intestinal-type mucinous carcinoma is a rare histological subtype of endometrial cancer. Differential diagnoses include Müllerian-type endometrial mucinous carcinoma, endocervical adenocarcinoma, metastasis from gastrointestinal tract adenocarcinoma and non-neoplastic gastric/intestinal metaplasia. However, the prognosis of endometrial intestinal-type mucinous carcinoma remains unclear due to limited reported cases. Existing evidence suggests a poorer prognosis compared with classical mucinous carcinomas of the endometrium. The present case, which is characterized by a polypoidal exophytic tumor without myometrial invasion, showed a favorable outcome. Further documentation and characterization of the aforementioned rare malignancy are necessary to enhance the understanding of its clinical physiology and outcomes. The present case report highlights the diagnostic challenges associated with intestinal-type mucinous endometrial carcinoma. The inclusion of this type of malignancy in the latest World Health Organization classification emphasizes the need for further comprehensive studies and case reports to expand the current knowledge on this rare histological subtype.

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