Morphologic Changes in Acute Central Serous Chorioretinopathy Evaluated by Fourier-Domain Optical Coherence Tomography

Fujimoto, Hisataka; Gomi, Fumi; Wakabayashi, Taku; Sawa, Miki; Tsujikawa, Motokazu; Tano, Yasuo

doi:10.1016/j.ophtha.2008.01.021

Cited by 161 publications

(130 citation statements)

References 26 publications

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“…In agreement with the findings of other authors (Fujimoto H et al 2008), our results suggest that PEDs are probably a relevant pathophysiological factor in the development of acute CSCR.…”

Section: Discussionsupporting

confidence: 93%

Alterations of intraretinal layers in acute central serous chorioretinopathy

Ahlers

Geitzenauer

Stock

et al. 2009

Acta Ophthalmologica

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ABSTRACT.Purpose: Optical coherence tomography (OCT) is restricted by its low scanning speed and limited resolution. High-definition raster-scanning OCT (HD-OCT) was used to evaluate changes in retinal microstructure in patients with acute central serous chorioretinopathy (CSCR) and to find new morphological features. Methods: Eighteen patients with subretinal fluid accumulation caused by acute CSCR were imaged in a cross-sectional study design. High-speed frequencydomain HD-OCT was used to image an area of 6 · 6 mm in the macular retina. Three-dimensional analyses were performed using en-face imaging and section analysis of single HD-OCT scans. Results: Detailed information about fluid accumulation can be obtained in all compartments. Discrete changes in reflectivity are visualized within the outer nuclear or plexiform layers in > 90% of patients. Subretinal fluid appears as a dome-shaped pool of fluid and is not associated with a loss of photoreceptor layer integrity. Deposits are demarcated beneath the outer cone segments. Multiple small pigment epithelial detachments are present in > 60% of patients. Conclusions: High-definition OCT provides extensive information regarding precise topographic and layer-specific localization of discrete morphological changes. Along with well-known changes in the retinal microstructure, hyperreflectivity can be imaged in the outer nuclear or plexiform layers and may represent intraretinal changes indicating the presence of subretinal pathologies or retinal maladjustment caused by the underlying pathology.

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“…In agreement with the findings of other authors (Fujimoto H et al 2008), our results suggest that PEDs are probably a relevant pathophysiological factor in the development of acute CSCR.…”

Section: Discussionsupporting

confidence: 93%

Alterations of intraretinal layers in acute central serous chorioretinopathy

Ahlers

Geitzenauer

Stock

et al. 2009

Acta Ophthalmologica

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“…However, PED prevalence may vary from 8% to 71% [11,18,19,22]. In our study, OCT did not show any PED in female cases.…”

Section: Discussioncontrasting

confidence: 61%

“…Montero et al reported that the hyperreflective small RPE bulging is present in 90% of the cases and they were related to leaking spots in FA [11]. However, it has been reported in an en face OCT study that it was detected in 35 % of the eyes with acute CSCR [19]. Additionally, RPE layer mapping study using OCT demonstrated that RPE bulging was in 94% of asymptomatic eyes in patients with CSR [25].…”

Section: Discussionmentioning

confidence: 98%

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Comparison of optical coherence tomography findings in males and females with acute central serous chorioretinopathy

Karanfil¹

2017

New Front Ophthalmol

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Objective: To compare the optical coherence tomography (OCT) findings in males and females with acute central serous chorioretinopathy (CSCR). Materials and methods:In this retrospective study, the OCT scans of 8 females (Group 1) and 16 males (Group 2) cases with acute CSCR which were diagnosed based on clinical, ophthalmological and OCT findings and which was followed in our hospital were retrospectively reviewed. The existence of the OCT findings and patterns regarding CSCR and sub-foveal choroidal thicknesses (SFCTs) were compared.Results: Serous macula detachment (SMD) was present in all of the female and male cases. The most common OCT finding was the brush-border pattern (6 cases, 75%) except SMD and retina pigment epithelium (RPE) bulging in females, and RPE bulging (14 cases, 87.5%) except SMD in males. There was no statistically significant difference in the frequency of OCT findings and patterns between both groups (p>0.05). The mean SFCTs of the eyes with CSCR in Group 1 and Group 2 were 346.08±32.1 µm (ranged from 338 to 365 µm) and 351.32±36.5 µm (ranged from 344 to 376 µm), respectively. The difference between SFCTs in the affected eyes was also not statistically significant (p>0.05).

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“…Further, a microrip or 'blow-out' in this PED has been postulated to result in a focal leak, which is observed as the point of leak on fluorescein angiogram. [4][5][6] Recently, a RPE defect within the PED at the leakage site has been reported on both time-domain 7 and fourier-domain OCT. 8 Fujimoto et al 8 observed RPE abnormalities at the site of leakage in 96% of eyes, with 22% of the eyes showing an RPE defect that was successfully treated with thermal laser photocoagulation. However, the natural course of these RPE abnormalities observed in the acute phase of CSC is not known.…”

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confidence: 99%

Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy

Gupta

Dogra

et al. 2009

Eye

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Purpose To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC). Methods Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted at presentation and follow-up. Results Transverse and RPE fit C-scans showed an irregularity of RPE resembling a 'honeycomb' pattern in 11 (85%) eyes at the point corresponding to the fluorescein leakage site. These were observed as pigment epithelium detachment (PED) on Raster line scan. Six of these 11 eyes (54.5%) showed a disruption/breach in the RPE on transverse C-scan and on RPE fit C-scan. All eyes showed a resolution of subretinal fluid with a closure of microrip, and the honeycombed pattern at the leakage site was replaced with RPE hypertrophy. Conclusion RPE microrips show spontaneous closure in the natural course of CSC.

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Morphologic Changes in Acute Central Serous Chorioretinopathy Evaluated by Fourier-Domain Optical Coherence Tomography

Cited by 161 publications

References 26 publications

Alterations of intraretinal layers in acute central serous chorioretinopathy

Alterations of intraretinal layers in acute central serous chorioretinopathy

Comparison of optical coherence tomography findings in males and females with acute central serous chorioretinopathy

Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy

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