Morphologic and Immunologic Studies of Subcutaneous Incisor Allografts in Mice

Mincer, Harry H.; Jennings, B. R.

doi:10.1177/00220345700490023101

Cited by 15 publications

(12 citation statements)

References 11 publications

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“…Later inflammatory episodes comprise mainly mononuclear leukocytes and thus correspond to the classic allograft reaction which commences 4 to 5 days post-operatively and reaches a peak shortly afterwards. A similar time scale of infiltration of tooth allografts has been observed (Shulman 1964, Shulman & Valente 1965, Mincer & Jennings 1970, Shulman & Kalis 1970, Klein 1971, Macedo-Sobrinho & Iranpour 1971, Riviere et al 1971. On the other hand it has been observed that infiltration does not begin until 2 or 3 weeks after grafting (Ivanyi & Vacek 1964a) or even later (Ivanyi 1965a, Weinreb et al 1968).…”

Section: The Allograft Reactionsupporting

confidence: 60%

“…Similar behavior to autografted and isografted tissue has been reported; namely recovery and renewal of dentinogenesis (Fong & Agnew 1958, Hoffman 1960, Ivanyi 1965a, Hoffman 1966, 1967, Weinreb et al 1968, Macedo-Sobrinho & Iranpour 1971. A number of authors have also observed that fibrous replacement of the pulp takes place (Ivanyi & Vacek 1964a, Ivanyi 1965a, 1965b, Fong et al 1968, Mincer & Jennings 1970. In still other experiments the pulp appears to remain empty or is filled with cell debris and no further dentinogenesis is seen (Ivanyi 1965a, Weinreb et al 1968, Macedo-Sobrinho & Iranpour 1971, Riviere et al 1971, Atkinson 1975.…”

Section: Allograftsmentioning

confidence: 53%

“…et al (1964) found that there was no significant decrease in epithelial eel! viability of second set skin whereas \ significant decrease was detected b) Mincer & Jennings (1970) and Klein i Secosky (1971). More recently , Goldstein et al (1975) mi Kardos & Heslop (1975) have all observe^ accelerated second set skin rejection following first set tooth allografts which takes place irrespective of the age of the donor tissue.…”

Section: Second Set Responsesmentioning

confidence: 96%

“…Tooth allografts exhibit similar changes to tooth autografts and isografts immediately after grafting, namely a degeneration of the cellular components of the graft (Shulman & Kalis 1970, Klein 1971. Again, degeneration appears to proceed from the cuspal cornua towards the cervix or apex (Fong & Agnew 1958, Ivanyi & Vacek 1964a, Fong et al 1968, Mincer & Jennings 1970, Atkinson 1975. Little has been recorded about the fate of the enamel organ in allografts although Ivanyi & Vacek (1964a) have claimed that it is still healthy 3 days after grafting whilst the dental papilla is degenerating.…”

Section: Allograftsmentioning

confidence: 99%

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Histopathological and immunological aspects of tooth transplantation

Atkinson

1978

J Oral Pathology Medicine

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Histopathological studies of teeth transplanted between genetically identical animals and to animals in which the immune response is suppressed or enhanced show that autografts and isografts degenerate but then are repaired, whereas allografts show a bewildering array of changes from almost total destruction to total repair. Some explanations for the repair of teeth in an immunologically hostile environment are put forward.The immunological aspects of tooth transplantation are also reviewed. Transplanted teeth stimulate an immune response from the host and are subject to the same rules of genetic relationship which apply to other tissues. Most components of the teeth are antigenic in isolation but only the pulp and periodontal ligament have so far been demonstrated to possess these properties //; vivo. Transplanted teeth also elicit antibody formation but the importance of antibodies in the rejection process is still disputed.It is concluded that teeth are not immunologically privileged tissues but will elicit cell mediated responses from allogeneic hosts and are subject to the same invasive destructive lesions as a result. The peculiar observations of repair of allogeneic teeth and delayed immune responses can be explained by considering the histopathology of transplanted teeth and their capacity for repair.Finally, the use of transplanted teeth to study odontogenesis and pathological entities such as odontogenic cysts and reparative dentin formation are briefly reviewed.

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Section: The Allograft Reactionsupporting

confidence: 60%

Section: Allograftsmentioning

confidence: 53%

Section: Second Set Responsesmentioning

confidence: 96%

Section: Allograftsmentioning

confidence: 99%

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Histopathological and immunological aspects of tooth transplantation

Atkinson

1978

J Oral Pathology Medicine

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“…In mice, teeth are able to sensitize the host's tissue although no histological differences could be detected between isotransplants and allotransplants. 6 Although there is no agreement yet, the participation of the periodontal ligament in the process has been considered for a long time. [5][6][7][8][9][10][11][12][13][14][15][16] Because of the controversial information in the literature and the technical difficulties involved in orthotopic dental transplantation in man and animals, we decided to study the receptor-tissue reaction to autotransplants and allotransplants of teeth inserted into the subcutaneous tissue of rabbits.…”

mentioning

confidence: 99%