Morphologic and histologic abnormalities in female and male rats treated with anabolic steroids

Abstract

A two-part study was performed to determine the effects of high doses of anabolic steroids on weight, appetite, and organ histology. Initially, 30 white Wistar rats, 15 males and 15 females, were treated weekly with either 0.52 cc of physiologic saline or nandrolone decanoate. After 6 weeks, female treated and control rats had comparable weight gains, but male treated rats were significantly lighter than controls. Rats were sacrificed and organs dissected for histologic preparation. Treated male livers had less lipid than control males. The uteri of treated females displayed abnormal vacuolization, stromal edema, and peliosis. In Part II, 12 male rats, 6 treated and 6 control, were given the drug or saline in a manner identical to that in Part I. Treated rats had lower weights from Weeks 1 through 6 and ate less than controls. Upon sacrifice, treated rats' kidneys were heavier, and testes and liver were lighter compared to controls. Roentgenographic studies of tibias from Parts I and II showed no significant differences in tibial length or height of growth plate between treated and control groups. In summary, when anabolic steroid use is studied in the rat model, numerous pathological and anatomical changes occur.

Effect of Nandrolone Decanoate (Anabolic Steroid) on the Liver and Kidney of Male Albino Rats and the Role of Antioxidant (Antox-Silymarin) as Adjuvant Therapy

“…However, observed that the liver weight of ND administered rats was lower as compared to control groups at the sixth week of the ND application [17]. In the another [18] study, the decrement of relative liver weight of ND administered rats was consistent with the observation of other research who suggested that this decrement may be due to the type of anabolic steroid, the form and duration of administration of the drug [17].…”

Stereological estimation of ovarian oocyte volume, surface area and number: application on mice treated with nandrolone decanoate

“…Some athletes (and non-athletes) abuse steroids in order to increase their muscular mass, power, and endurance [2]. The side effects of anabolic steroids on the physiology and function of the reproductive system have been proved [3]. The side effects of steroids on the histology of testis [4], prostate [5], ovary, and uterus [6][7], spermatogenesis [8], genitalia malformation, and ovarian cyclical activity [1,[9][10][11] have also been shown.…”

O papel do esteroide anabolizante sobre a hipertrofia e força muscular em treinamentos de resistência aeróbia e de força

“…The AS influence on body mass is still very argued in the literature. In previous investigations, Yu-Yahiro et al (17) , showed reduction in body mass in rats treated with AS, being it associated with appetite decrease in these animals. On the other hand, other authors have not observed differences in rats treated with AS (18) .…”