Morphokinetics of embryos after IMSI versus ICSI in couples with sub‐optimal sperm quality: A time‐lapse study

Boediono, Arief; Handayani, Nining; Sari, Henny Natalya; Yusup, Nuraeni; Indrasari, Wahyu; Polim, Arie A; Sini, Ivan

doi:10.1111/and.14002

Cited by 7 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using this method, most of the studies compiled herein (57.2%) revealed an improvement in ART outcomes [16,18,20,22,25,26,28,30,33,35,36]. Other articles (42.8%), however, did not find differences between advanced and traditional sperm selection methods regarding ART outcomes [19,21,23,24,29,31,32,34]. Differences in laboratory/clinical procedures or in exclusion/inclusion factors, such as patient selection criteria (age, female factors or male factors), could be behind these inconsistent results.…”

Section: Using Advanced Sperm Selection Techniques Improves Art Outcomesmentioning

confidence: 85%

“…Indeed, Oliveira et al [32] and Gatimel et al [24] did not find statistically significant differences in pregnancy and implantation rates between IMSI and conventional ICSI in patients with recurrent implantation failure. Similarly, the study by Boediono et al [21] included females with severe endometriosis and observed no improvement in clinical pregnancy rates. Not only do these studies suggest that the success of IMSI relies on the patient, but they also support that further research should include a larger sample size to establish in which clinical conditions IMSI could bring the most benefit.…”

Section: Using Advanced Sperm Selection Techniques Improves Art Outcomesmentioning

confidence: 94%

See 1 more Smart Citation

Advanced Sperm Selection Strategies as a Treatment for Infertile Couples: A Systematic Review

Ribas-Maynou

Barranco

Sorolla-Segura

et al. 2022

IJMS

View full text Add to dashboard Cite

Assisted reproductive technology (ART) is an essential tool to overcome infertility, and is a worldwide disease that affects millions of couples at reproductive age. Sperm selection is a crucial step in ART treatment, as it ensures the use of the highest quality sperm for fertilization, thus increasing the chances of a positive outcome. In recent years, advanced sperm selection strategies for ART have been developed with the aim of mimicking the physiological sperm selection that occurs in the female genital tract. This systematic review sought to evaluate whether advanced sperm selection techniques could improve ART outcomes and sperm quality/functionality parameters compared to traditional sperm selection methods (swim-up or density gradients) in infertile couples. According to preferred reporting items for systematic reviews and meta-analyses (PRISMA guidelines), the inclusion and exclusion criteria were defined in a PICOS (population, intervention, comparator, outcome, study) table. A systematic search of the available literature published in MEDLINE-PubMed until December 2021 was subsequently conducted. Although 4237 articles were recorded after an initial search, only 47 studies were finally included. Most reports (30/47; 63.8%) revealed an improvement in ART outcomes after conducting advanced vs. traditional sperm selection methods. Among those that also assessed sperm quality/functionality parameters (12/47), there was a consensus (10/12; 83.3%) about the beneficial effect of advanced sperm selection methods on these variables. In conclusion, the application of advanced sperm selection methods improves ART outcomes. In spite of this, as no differences in the reproductive efficiency between advanced methods has been reported, none can be pointed out as a gold standard to be conducted routinely. Further research addressing whether the efficiency of each method relies on the etiology of infertility is warranted.

show abstract

Section: Using Advanced Sperm Selection Techniques Improves Art Outcomesmentioning

confidence: 85%

Section: Using Advanced Sperm Selection Techniques Improves Art Outcomesmentioning

confidence: 94%

Advanced Sperm Selection Strategies as a Treatment for Infertile Couples: A Systematic Review

Ribas-Maynou

Barranco

Sorolla-Segura

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Sperm volume, concentration, and motility were evaluated according to the "WHO laboratory manual for the examination and processing of human semen" (2010). Semen samples were subsequently processed by an albumin gradient, density gradient, swim-up, or simple wash technique according to our clinic's standard operating procedure as described previously [19]. The final sperm postwash count and motility were then examined.…”

Section: Sperm Preparationmentioning

confidence: 99%

Clinical Pregnancy Is Not Associated with Sperm Quality in POSEIDON Group 1 and 2 Patients

Handayani

Sundari²,

Aprilliana³

et al. 2023

Andrologia

Self Cite

View full text Add to dashboard Cite

This study is aimed at establishing the effects of varying sperm quality on IVF-ICSI/IMSI outcomes in unexpected poor ovarian responder subjects of POSEIDON groups 1 and 2. In the present study, 1,263 couples with female partners who fulfilled the POSEIDON group 1 and 2 criteria were recruited. All couples underwent ICSI or IMSI at Morula IVF Jakarta Clinic, Indonesia. Patients were subsequently classified into six groups, according to semen conditions of the respective male partners: (1) normozoospermic, (2) teratozoospermia, (3) oligoasthenoteratozoospermia (OAT), (4) asthenozoospermia, (5) severe OAT, and (6) cryptozoospermia. Laboratory and clinical outcomes of the IVF-ICSI/IMSI program were then evaluated. Early and late embryonic development parameters including the number of fertilization, cleavage and blastocyst stages, and blastocyst quality differed significantly among the different sperm quality groups ( p < 0.05 ). No difference was observed in the number of embryo transfers and clinical pregnancy among the studied groups ( p > 0.05 ). Our study has demonstrated the effect of sperm quality on embryo development at the early and later stages; however, the clinical pregnancy was not impaired in the unexpected poor responders of POSEIDON groups 1 and 2.

show abstract

“…[ 35 ] concluded that only patients with repeated implantation failures, severe male infertility factors or advanced male or maternal ages had higher chances of conceiving with IMSI. However, only a few articles in the literature focus on the use of MSOME and IMSI on normal/subnormal sperm [ 36 – 40 ].…”

Section: Introductionmentioning

confidence: 99%

First-line infertility treatment in normal or subnormal sperm: Interest of a simplified pre-IMSI test

Sigala,

Poirey,

Robert

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background In the field of male infertility, when sperm is normal/subnormal, a few “add-on” routine tests can complete the basic semen examination. Objectives The aim of this study was to develop and evaluate a faster, simplified motile sperm organelle morphology examination (MSOME) technique for selected infertile patients with apparently normal/subnormal sperm and, in their background: failure of two or three intrauterine insemination (IUI) cycles, repeatedly fragmented embryos, embryonic development to blastocyst-stage failures, repeated miscarriages, a long period of infertility or 2 or more IVF attempts without pregnancy. Our test results were correlated with IUI, conventional in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and intracytoplasmic morphologically selected sperm injection (IMSI) outcomes. Materials and methods We validated an adapted version of the MSOME analysis called the pre-IMSI test (PIT), based on vacuole evaluation alone. 248 infertile patients from our assisted reproductive technology (ART) Center were retrospectively selected and split into three PIT score subgroups (patients with ≤8% (score I), 9 to 15% (score II) and ≥16% normal spermatozoa (score III)) based on the correlation between PIT results and each ART technique outcome. The choice of one or another of these ART techniques had been made according to the usual clinico-biological criteria. Results Clinical outcomes for each of the three PIT subgroups were compared individually for the different ART techniques. For ICSI, the effect of the PIT score subgroup was significant for clinical pregnancies (p = 0.0054) and presented a trend for live births (p = 0.0614). Miscarriage rates of IVF attempts were statistically different depending on the PIT score (p = 0.0348). Furthermore, the odds ratios of clinical pregnancy rates were significantly different according to PIT score subgroup when comparing ICSI vs. IMSI or IVF vs. ICSI attempts. Discussion IMSI appears to be recommended when sperm belongs to PIT score I, ICSI when it belongs to PIT score II and IVF or IUI when sperm is of PIT score III quality in selected infertile couples. The lack of statistical power in these PIT subgroups means that we must remain cautious in interpreting results. Conclusion Our results support the interest of this simplified test for certain couples with normal/subnormal sperm to help choose the most efficient ART technique, even as first-line treatment.

show abstract

Morphokinetics of embryos after IMSI versus ICSI in couples with sub‐optimal sperm quality: A time‐lapse study

Cited by 7 publications

References 45 publications

Advanced Sperm Selection Strategies as a Treatment for Infertile Couples: A Systematic Review

Advanced Sperm Selection Strategies as a Treatment for Infertile Couples: A Systematic Review

Clinical Pregnancy Is Not Associated with Sperm Quality in POSEIDON Group 1 and 2 Patients

First-line infertility treatment in normal or subnormal sperm: Interest of a simplified pre-IMSI test

Contact Info

Product

Resources

About