Morphogenic plasticity: the pathogenic attribute of Candida albicans

Prasad, Priya; Tippana, Meena

doi:10.1007/s00294-023-01263-5

Cited by 9 publications

(5 citation statements)

References 156 publications

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“…C. albicans is a common opportunistic pathogen and a commensal microbe in human systems. It takes on several morphogenic forms in order to thrive in diverse host niches with varying environmental conditions (Prasad and Tippana 2023). Our findings about the dominant species were nearly consistent with the results previously mentioned by Bitew and Abebaw (2018) and Xiao et al (2022).…”

Section: Isolation Distribution and Phenotypic Identification Of Yeastssupporting

confidence: 92%

Phenotypic and genotypic diversity of yeast isolated from cancer patients and their environment and their antifungal sensitivity pattern

AL-DARRAJI,

MOHAMMED-AMEEN

2023

Biodiversitas

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Abstract. Al-Darraji ZDG, Mohammed-Ameen MKM. 2023. Phenotypic and genotypic diversity of yeast isolated from cancer patients and their environment and their antifungal sensitivity pattern. Biodiversitas 24: 4166-4174. This study aimed to investigate yeast diversity and their antifungal susceptibility patterns in 853 samples collected from cancer patients, their apparently healthy companions, their beds, their tables, and indoor hospital air. The samples were cultured and identified using classical phenotypic characteristics and a molecular method utilizing amplification of ITS conservative regions of rRNA. The sum of phenotyping and genotyping identification revealed that 102 yeast isolates included 6 genera and 14 species. Candida sp. was the most dominant genera (84.31%), followed by Naganishia sp. (10.78%). Candida albicans (24.50%) and C. krusei (16.66%) were the most prevalent yeast species. Fluconazole, caspofungin, and voriconazole exhibited potent antifungal activities against the most yeast species with low minimum inhibitory concentration (MIC) values compared with high MIC (64 µg/mL) values against Meyerozyma guilliermondi, Naganishia difflunes, and C. tropicalis. To conclude, the antifungal activity was isolate- and species-specific and the higher antifungal concentrations led to a more-rapid expression of activity. The high isolation rate of yeasts from beds and tables, advocated the use of various monitoring systems to ensure thorough cleaning and consistent disinfection of surfaces around patients and health care providers. The study findings showed that the molecular method was superior to the phenotyping technique in identifying yeast isolates. While similar research has been performed in different locations, the current project represents a unique milestone for this particular institution, and offers an opportunity to advance research in this area.

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Section: Isolation Distribution and Phenotypic Identification Of Yeastssupporting

confidence: 92%

Phenotypic and genotypic diversity of yeast isolated from cancer patients and their environment and their antifungal sensitivity pattern

AL-DARRAJI,

MOHAMMED-AMEEN

2023

Biodiversitas

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“…Candida albicans is a commensal organism of the human gastrointestinal tract and a prevalent opportunistic pathogen. It exhibits different morphogenic forms to facilitate its survival in different host niches with distinct environmental conditions (Prasad and Tippana 2023). In this study, the frequency of Candida sp.…”

Section: Identification Of Candida Spp Isolatesmentioning

confidence: 83%

Molecular determination of the microbial diversity associated with vaginitis and testing their sensitivity to selected antimicrobials

AL-ZAIDI,

AL-TAMIMI,

SALEH

2023

Biodiversitas

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Abstract. Al-Zaidi MHH, Al-Tamimi WH, Saleh AAA. 2023. Molecular determination of the microbial diversity associated with vaginitis and testing their sensitivity to selected antimicrobials. Biodiversitas 24: 4253-4261. Millions of women suffer from bacterial vaginitis is associated with several serious health problems. The present study aimed to investigate the microbial diversity and their sensitivity to different antimicrobial agents. Bacterial isolates were identified by genotyping using the 16S rRNA gene sequencing and BLASTn analysis, while conventional mycological methods identified Candida spp. The disc diffusion method was used to study the antimicrobial susceptibility patterns. The molecular identification showed that Escherichia coli (20.8%) and Staphylococcus haemolyticus (20.8%) were the most frequent species, followed by Klebsiella pneumoniae (16.7%). At the same time, Macrococcus caseolyticus, Streptococcus agalactiae, Staphylococcus aureus, and Bacillus cereus were the least prevalent bacteria (4.16%)—all Candida sp. against the selected antimicrobial agents. Thus, molecular assays are important in monitoring microorganisms associated with vaginitis. Prospective genotyping studies are needed to determine these microbes' resistant genes and understand their mode of action and response to drug therapy.

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“…This model has successfully been used to assess the effects of F, alone or associated with polyphosphates, as well as antifungal drugs [ 10 , 20 ]. However, this model has not been previously used to assess the effects of polyols, so some aspects deserve comment, especially the complexity of this fungus and the different size of the microorganism structure compared to prokaryotic cells [ 35 ]. Moreover, when sucrose is present in the medium, a higher number of hyphae cover the biofilm, which leads to a denser structure that hinders the access of actives to act over the biofilm cells [ 28 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Solutions Containing Fluoride, Sodium Trimetaphosphate, Xylitol, and Erythritol, Alone or in Different Associations, on Dual-Species Biofilms

Zen,

Delbem,

Martins

et al. 2023

IJMS

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Although the association of polyols/polyphosphates/fluoride has been demonstrated to promote remarkable effects on dental enamel, little is known on their combined effects on biofilms. This study assessed the effects of solutions containing fluoride/sodium trimetaphosphate (TMP)/xylitol/erythritol on dual-species biofilms of Streptococcus mutans and Candida albicans. Biofilms were grown in the continuous presence of these actives alone or in different associations. Quantification of viable plate counts, metabolic activity, biofilm biomass, and extracellular matrix components were evaluated. Overall, fluoride and TMP were the main actives that significantly influenced most of the variables analyzed, with a synergistic effect between them for S. mutans CFUs, biofilm biomass, and protein content of the extracellular matrix (p < 0.05). A similar trend was observed for biofilm metabolic activity and carbohydrate concentrations of the extracellular matrix, although without statistical significance. Regarding the polyols, despite their modest effects on most of the parameters analyzed when administered alone, their co-administration with fluoride and TMP led to a greater reduction in S. mutans CFUs and biofilm biomass compared with fluoride alone at the same concentration. It can be concluded that fluoride and TMP act synergistically on important biofilm parameters, and their co-administration with xylitol/erythritol significantly impacts S. mutans CFUs and biomass reduction.

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Morphogenic plasticity: the pathogenic attribute of Candida albicans

Cited by 9 publications

References 156 publications

Phenotypic and genotypic diversity of yeast isolated from cancer patients and their environment and their antifungal sensitivity pattern

Phenotypic and genotypic diversity of yeast isolated from cancer patients and their environment and their antifungal sensitivity pattern

Molecular determination of the microbial diversity associated with vaginitis and testing their sensitivity to selected antimicrobials

Evaluation of Solutions Containing Fluoride, Sodium Trimetaphosphate, Xylitol, and Erythritol, Alone or in Different Associations, on Dual-Species Biofilms

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