Morphogenetic systems: Models and experiments

Smolka, Vladimír; Drastík, Jan; Bradík, Jaroslav; Garzón, Max H.; Sosík, Petr

doi:10.1016/j.biosystems.2020.104270

Cited by 4 publications

(1 citation statement)

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“…In this section we briefly recall the concept of self-healing introduced in [ 18 ] and further elaborated in [ 46 ]. A configuration (or state ) of a given M system is a full description or listing of all the objects present in the system at a given time, including their location in the container space (3D space) and their attachments to one another to form substructures (such as membranes or cytoskeletons).…”

Section: Resultsmentioning

confidence: 99%

A Self-Controlled and Self-Healing Model of Bacterial Cells

et al. 2022

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A new kind of self-assembly model, morphogenetic (M) systems, assembles spatial units into larger structures through local interactions of simpler components and enables discovery of new principles for cellular membrane assembly, development, and its interface function. The model is based on interactions among three kinds of constitutive objects such as tiles and protein-like elements in discrete time and continuous 3D space. It was motivated by achieving a balance between three conflicting goals: biological, physical-chemical, and computational realism. A recent example is a unified model of morphogenesis of a single biological cell, its membrane and cytoskeleton formation, and finally, its self-reproduction. Here, a family of dynamic M systems (Mbac) is described with similar characteristics, modeling the process of bacterial cell formation and division that exhibits bacterial behaviors of living cells at the macro-level (including cell growth that is self-controlled and sensitive to the presence/absence of nutrients transported through membranes), as well as self-healing properties. Remarkably, it consists of only 20 or so developmental rules. Furthermore, since the model exhibits membrane formation and septic mitosis, it affords more rigorous definitions of concepts such as injury and self-healing that enable quantitative analyses of these kinds of properties. Mbac shows that self-assembly and interactions of living organisms with their environments and membrane interfaces are critical for self-healing, and that these properties can be defined and quantified more rigorously and precisely, despite their complexity.

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Section: Resultsmentioning

confidence: 99%