Morphogenetic effect of kainate on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor

Suzuki, Fumio; Junier, Marie‐Pierre; Guilhem, D.; Sørensen, J.C.; Onténiente, Brigitte

doi:10.1016/0306-4522(94)00463-f

Cited by 196 publications

(187 citation statements)

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“…In addition to changes in the cell density and thickness of the granule cell layer, the granule cells appeared larger than normal with thickening of proximal dendrites. Similar pathology has been reported in patients with temporal lobe epilepsy (Houser et al, 1990) and in rats months after kainic acid lesions of the hippocampus (Suzuki et al, 1995). After finding this pathology in WH, we reexamined his medical records and reinterviewed his wife regarding his seizures.…”

Section: Patient Whsupporting

confidence: 67%

Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation

et al. 1996

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Patient RB (Human amnesia and the medial temporal region: enduring memory impairment following a bilaterial lesion limited to field CA1 of the hippocampus, S. Zola-Morgan, L. R. Squire, and D. G. Amaral, 1986, J Neurosci 6:2950 -2967 was the first reported case of human amnesia in which detailed neuropsychological analyses and detailed postmortem neuropathological analyses demonstrated that damage limited to the hippocampal formation was sufficient to produce anterograde memory impairment. Neuropsychological and postmortem neuropathological findings are described here for three additional amnesic patients with bilateral damage limited to the hippocampal formation. Findings from these patients, taken together with the findings from patient RB and other amnesic patients, make three important points about memory. (1) Bilateral damage limited primarily to the CA1 region of the hippocampal formation is sufficient to produce moderately severe anterograde memory impairment. (2) Bilateral damage beyond the CA1 region, but still limited to the hippocampal formation, can produce more severe anterograde memory impairment. (3) Extensive, temporally graded retrograde amnesia covering 15 years or more can occur after damage limited to the hippocampal formation. Findings from studies with experimental animals are consistent with the findings from amnesic patients. The present results substantiate the idea that severity of memory impairment is dependent on locus and extent of damage within the hippocampal formation and that damage to the hippocampal formation can cause temporally graded retrograde amnesia.

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Section: Patient Whsupporting

confidence: 67%

Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation

et al. 1996

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“…However, our data suggest that in the adult primate, these alterations can take place after injury (SE) during adult life, even within a few months. Comparatively, while prominent in rodent SE models (Mello et al, 1992;Suzuki et al, 1995), granule cell dispersion is not as frequent in humans with TLE (Houser, 1990). Similarly, dentate neurogenesis is quite robust in rodents Parent et al, 1997) but rather discrete in adult non-human primates (Gould et al, 1999) and in humans (Eriksson et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate

et al. 2011

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“…Additionally, growth properties of cultured neonatal dentate granule cells are influenced by exogenously applied BDNF. 47 Lastly, Suzuki et al 48 have demonstrated that injection of kainate into the hippocampus is associated with a long-lasting global trophic response of granule cells involving somatic and dendritic growth, which is correlated with a specific overexpression of BDNF. A potential limitation of this study is that casecontrol association studies can be influenced by undetected population stratification.…”

Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation

et al. 2005

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Magnetic resonance (MR) imaging studies have identified hippocampal structural alterations in the pathogenesis of schizophrenia. Brain-derived neurotrophic factor (BDNF) is one of the neurotrophins that is widely expressed in the hippocampal formation and has been implicated in the neurobiology of schizophrenia. Polymorphisms in the BDNF gene may therefore confer risk for schizophrenia through hippocampal pathogenesis and/or making the hippocampus more susceptible to environmental insults. In this study, we investigated whether val66met, a functional and abundant missense polymorphism in the coding region of the BDNF gene, was associated with the volume of the hippocampal formation in 19 patients with first-episode schizophrenia and 25 healthy volunteers. A total of 124 contiguous T1-weighted coronal MR images (slice thickness ¼ 1.5 mm) were acquired through the whole head using a 3D Fast SPGR IR Prep sequence on a 1.5 T GE imaging system. Volumes of the right and left hippocampal formation were measured manually by an operator blind to group status and genotype. All participants were genotyped for the BDNF val66met locus. Mixed model analyses revealed a main effect of BDNF val66met genotype such that in the combined sample of patients and healthy volunteers, val/val homozygotes (N ¼ 27) had larger volumes of the hippocampal formation compared to val/met heterozygotes (N ¼ 17). In separate analyses by group, however, val66met genotype accounted for a greater proportion of the variance in the volume of the hippocampal formation in patients compared to healthy volunteers. These findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers. Molecular Psychiatry (2005) 10, 631-636.

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Morphogenetic effect of kainate on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor

Cited by 196 publications

References 50 publications

Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation

Three Cases of Enduring Memory Impairment after Bilateral Damage Limited to the Hippocampal Formation

Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate

Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation

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