Morphogenetic and Homeostatic Self-assembled Systems

Sosík, Petr; Smolka, Vladimír; Drastík, Jan; Moore, Tyler G.; Garzón, Max H.

doi:10.1007/978-3-319-58187-3_11

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…A typical reaction rule has the form u → v , where u (reactants) and v (products) are multisets which may contain floating objects, protions, and/or tiles. A more detailed, but also more technical, description of M systems can be found in [ 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…A nontrivial example of such an M system is described in [ 17 ]. This system produces a model M 0 of a living cell self-assembled from basic pentagonal tiles and undergoing a sort of morphogenetic process to generate a cytoskeleton in its interior, eventually producing a copy of itself, akin to a mitotic division.…”

Section: Methodsmentioning

confidence: 99%

“…Motivated by these considerations, [ 17 , 18 ] recently proposed a dynamic computational model, M systems, based in part on the techniques of membrane computing [ 19 ]. M systems arose as an evolution of so-called membrane systems (or P systems, [ 19 ]), which generally consist of a structure of (possibly nested) delimiting regions in 2D or 3D space enclosed by membranes, as illustrated below, and as a mathematical abstraction of common biological structures.…”

Section: Introductionmentioning

confidence: 99%

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A Self-Controlled and Self-Healing Model of Bacterial Cells

et al. 2022

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A new kind of self-assembly model, morphogenetic (M) systems, assembles spatial units into larger structures through local interactions of simpler components and enables discovery of new principles for cellular membrane assembly, development, and its interface function. The model is based on interactions among three kinds of constitutive objects such as tiles and protein-like elements in discrete time and continuous 3D space. It was motivated by achieving a balance between three conflicting goals: biological, physical-chemical, and computational realism. A recent example is a unified model of morphogenesis of a single biological cell, its membrane and cytoskeleton formation, and finally, its self-reproduction. Here, a family of dynamic M systems (Mbac) is described with similar characteristics, modeling the process of bacterial cell formation and division that exhibits bacterial behaviors of living cells at the macro-level (including cell growth that is self-controlled and sensitive to the presence/absence of nutrients transported through membranes), as well as self-healing properties. Remarkably, it consists of only 20 or so developmental rules. Furthermore, since the model exhibits membrane formation and septic mitosis, it affords more rigorous definitions of concepts such as injury and self-healing that enable quantitative analyses of these kinds of properties. Mbac shows that self-assembly and interactions of living organisms with their environments and membrane interfaces are critical for self-healing, and that these properties can be defined and quantified more rigorously and precisely, despite their complexity.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%