Morphogenesis of thyropathies according to expression Oct3/4, PHH3, CK8, CK18 in chronic endogenous intoxication

Abstract

Regeneration of internal organs under conditions of negative environmental impact, as well as adaptation to changing conditions of internal homeostasis in conditions of illness, is an urgent problem in regenerative medicine. The key links in the regulation of homeostasis are neuro-immune-endocrine relationships, where the main role in the regulation of metabolism is assigned to the thyroid gland. Morphological changes in the thyroid parenchyma under conditions of altered homeostasis in chronic endogenous intoxication (CEI) can lead to the formation of undiagnosed thyroid disorders and are not taken into the development of thanatogenesis. We conducted an IHC study to determine the main patterns of development of regenerative and adaptive processes of thyrocytes in conditions of CEI based on the expression of thyrocyte proliferation factors (PHH3), stem cells (Oct3/4), as well as to determine the risk of developing malignant neoplasms (CK8, CK18). It was found that in the formation of nodular neoplasms with a pronounced expression of PHH3 with a mitotic index of more than 25 %, it is necessary to conduct an IHC study to determine the expression of CK8, CK18 to identify the risk of developing thyroid neoplasms.