Morphogenesis of the special circular muscle layer and of the interstitial cells of Cajal related to the plexus muscularis profundus of mouse intestinal muscle coat

Pellegrini, Maria Simonetta Faussone

doi:10.1007/bf00303144

Cited by 36 publications

(26 citation statements)

References 6 publications

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“…Interestingly, the intensity of the labelling for the NK1r was at its maximum at 7 days of postnatal life, while that for SP reached the highest intensity in the adult age. TEM studies [85] have shown that ICC-DMP acquire the adult features during the first week of post-natal life and that their differentiative steps are temporally related to those of the nerve plexuses. The difference between the earliest ages and adulthood in the NK1r distribution on the ICC-DMP probably depends on a progressive membrane re-organization of the receptors in a cell that increases in size and changes in shape.…”

Section: Nk1r-ir Icc-dmp and Sp-ir Nerves During Gut Developmentmentioning

confidence: 99%

Relationships between neurokinin receptor‐expressing interstitial cells of Cajal and tachykininergic nerves in the gut

Faussone–Pellegrini

2006

J Cellular Molecular Medi

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The so-called interstitial cells of Cajal (ICC) are distributed throughout the muscle coat of the alimentary tract with characteristic intramural location and species-variations in structure and staining. Several ICC sub-types have been identified: ICC-DMP, ICC-MP, ICC-IM, ICC-SM. Gut motility is regulated by ICC and each sub-type is responsible for the electrical activities typical of each gut region and/or muscle layer. The interstitial position of the ICC between nerve endings and smooth muscle cells has been extensively considered. Some of these nerve endings contain tachykinins. Three distinct tachykinin receptors (NK1r, NK2r and NK3r) have been demonstrated by molecular biology. Each of them binds with different affinities to a series of tachykinins (SP, NKA and NKB). In the ileum, SP-immunoreactive (SP-IR) nerve fibers form a rich plexus at the deep muscular plexus (DMP), distributed around SP-negative cells, and ICC-DMP intensely express the SP-preferred receptor NK1r; conversely a faint NK1r-IR is detected on the ICC-MP and mainly after receptor internalization was induced by agonists. ICC-IM are never stained in laboratory mammals, while those of the human antrum are NK1r-IR. RT-PCR conducted on isolated ileal ICC-MP and gastric ICC-IM showed that these cells express NK1r and NK3r. Colonic ICC, except those in humans, do not express NK1r-IR, at least in resting conditions. Outside the gut, NK1r-IR cells were seen in the arterial wall and exocrine pancreas. In the mouse gut only, NK1r-IR is present in non-neuronal cells located within the intestinal villi, so-called myoid cells, which are c-kit-negative and α-smooth muscle actin-positive. Immunohistochemistry and functional studies confirmed that ICC receive input from SP-IR terminals, with differences between ICC sub-types. In the rat, very early after birth, NK1r is expressed by the ICC-DMP and SP by the related nerve varicosities. Studies on pathological conditions are few and those on mutant strains practically absent. It has only been reported that in the inflamed ileum of rats the NK1r-IR ICC-DMP disappear and that at the peak of inflammatory conditions ICC-MP are NK1r-IR. In the ileum of mice with a mutation in the W locus, ICC-DMP were seen to express c-kit-IR but not NK1-IR, and SP-IR innervation seems unchanged. In summary, there are distinct ICC populations, each of them under a different tachykininergic control and, likely, having different functions. Further studies are recommended at the aim of understanding ICC involvement in modulating/transmitting tachykininergic inputs.

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Section: Nk1r-ir Icc-dmp and Sp-ir Nerves During Gut Developmentmentioning

confidence: 99%

Relationships between neurokinin receptor‐expressing interstitial cells of Cajal and tachykininergic nerves in the gut

Faussone–Pellegrini

2006

J Cellular Molecular Medi

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“…Faussone-Pellegrini (1984) was more cautious, in that she also referred to these cells as ''ICC blast-like cells,'' which could not be identified with certainty. Torihashi and coworkers (Willenbucher et al, 1992;Torihashi et al, 1997) reported that such ICC blast cells were not observed at day 18 of gestation.…”

Section: Ontogenesis Of the Pacemaker Activity In Neonatal Mouse Smalmentioning

confidence: 99%

Development of pacemaker activity and interstitial cells of cajal in the neonatal mouse small intestine

1998

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“…Cytodifferentiation of the interstitial cells of Cajal (ICC) from fetal to adult life has been studied only in the small intestine of the mouse [Faussone-Pellegrini, 1984. 1985a.…”

Section: Introductionmentioning

confidence: 99%

Cytodifferentiation of the Interstitial Cells of Cajal of Mouse Colonic Circular Muscle Layer

Pellegrini¹

1987

Cells Tissues Organs

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Cytodifferentiation of the interstitial cells of Cajal related to the plexus entericus extremus and located on the inner face of the circular muscle layer of the mouse colon was studied in fetuses at term, unfed neonates, suckling and weaning young animals. In fetuses at term, the interstitial cells of Cajal are not found and their precursor cells are not identifiable among the cells present in the submucosal area facing the circular muscle layer, i.e., undifferentiated cells (mainly close to nerve fibers) and fibroblast-like cells (contacting each other and the developing smooth-muscle cells). Cells putatively considered as precursors of interstitial cells of Cajal, fibroblast-like cells rich in mitochondria, are present in unfed neonates (in small numbers) and in suckling animals (in large numbers). Differentiating interstitial cells of Cajal are undoubtedly recognizable during the second week of postnatal life (suckling period). Some of them have mixed fibroblastic- and interstitial-cell features and some have many interstitial-cell features. Both these cell types are already in contact with each other and differentiating and differentiated smooth-muscle cells. The undifferentiated cells, still present in unfed neonates, envelop the nerve fibers and differentiate as Schwann cells during the suckling period. During this period, as the nerve endings of the plexus entericus extremus develop, they immediately contact the differentiating interstitial cells of Cajal. During the weaning period, these cells are quite well differentiated although they do not have the same morphology as in adult animals before 30 days of age. Concomitantly, the nerve endings of the plexus entericus extremus contain an increasing number of synaptic vesicles.

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Morphogenesis of the special circular muscle layer and of the interstitial cells of Cajal related to the plexus muscularis profundus of mouse intestinal muscle coat

Cited by 36 publications

References 6 publications

Relationships between neurokinin receptor‐expressing interstitial cells of Cajal and tachykininergic nerves in the gut

Relationships between neurokinin receptor‐expressing interstitial cells of Cajal and tachykininergic nerves in the gut

Development of pacemaker activity and interstitial cells of cajal in the neonatal mouse small intestine

Cytodifferentiation of the Interstitial Cells of Cajal of Mouse Colonic Circular Muscle Layer

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