Morphogenesis by Orientated Cell Division

Davies, Jamie A.

doi:10.1016/b978-0-12-391062-2.00023-1

Cited by 1 publication

(1 citation statement)

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“…Morphogenesis is the biological process that causes an organism to develop its shape 40 . This process usually requires the pattering of cells via their spatial distribution during the embryonic development of an organism 41 . As it turns out, there are common mechanisms found in both DoL and morphogenesis, as seen, for example, in the patterning of nitrogen-fixing cells in cyanobacteria 15 .…”

Section: Cells Model Parameters In This Circuit Include the Diffusiomentioning

confidence: 99%

Deriving general conditions and mechanisms for division of labor using the cell-based simulator `gro`

Gregorio-Godoy

Rodríguez-Regueira

et al. 2018

Preprint

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Division of Labor can occur as a consequence of a major evolutionary transition such as multicellularity but is also found in societies of similar individuals like microbes. It has been defined as a process that occurs when cooperating individuals specialize to carry out specific tasks in a distributed manner. This paper analyzes the conditions for division of labor to emerge as a beneficial evolutionary solution and proposes two novel mechanisms for this process to emerge as a consequence of cell communication in an isogenic group of cells. The study is conducted by means of the cell-based model gro that simulates the growth and interaction of cells in a two-dimensional bacterial colony. When the labor is social, like the production of a molecule that is publicly shared, simulation results indicate that division of labor provides higher fitness than individual labor if the benefits of specialization are accelerating. Two genetic networks that 2 generate consensual and reversible specialization are presented and characterized. In the proposed mechanisms, cells self-organize through the exchange of certain molecules and coordinate behaviors at the local level without the requirements of any fitness benefits. In addition, the proposed regulatory mechanisms are able to create de novo patterns unprecedented to this date that can scale with size. MAIN TEXTMulticellularity is considered one of the major transitions in evolution, a concept that encompasses the phenomena in which natural selection transforms autonomously replicative genes/cells/individuals into new higher-level structures 1,2 . In such structures, individuals are no longer independent of each other but rather form a group that coordinates and communicates with a resulting behavior that is determined by the interaction of its fundamental elements 2 . One of this major transitions is multicellularity 3 . It has been identified that multicellularity has evolved independently more than 20 times, at least once in animals, three times in fungi, six times in algae, and multiple times in bacteria 4 .Multicellularity has involved different evolutionary pathways, leading to the belief that there is not a single explanation for its origins. However, some requirements have been identified across many species and are thought to be essential to meet the current definition of what constitutes a multicellular organism 5 . The evolutionary requirements for multicellularity include (i) the formation of clusters of cells via physical contact or adhesion to form a new evolutionary unit 6 , and (ii) communication among the individuals leading to coordinated activity 7 .There are some essential disadvantages to multicellularity. For example, it is much costly to adhere and communicate with your neighbors than to live a solitary life. Employing strategies that assure communication and encourage cooperation to reduce possible conflicts within the group does not 3 come for free 8 . Yet, these pitfalls can be greatly compensated by the benefits that multicellularity can provide. ...

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Section: Cells Model Parameters In This Circuit Include the Diffusiomentioning

confidence: 99%

Deriving general conditions and mechanisms for division of labor using the cell-based simulator `gro`

Gregorio-Godoy

Rodríguez-Regueira

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

Morphogenesis by Orientated Cell Division

Cited by 1 publication

References 40 publications

Deriving general conditions and mechanisms for division of labor using the cell-based simulator `gro`

Deriving general conditions and mechanisms for division of labor using the cell-based simulator `gro`

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Morphogenesis by Orientated Cell Division

Cited by 1 publication

References 40 publications

Deriving general conditions and mechanisms for division of labor using the cell-based simulator gro

Deriving general conditions and mechanisms for division of labor using the cell-based simulator gro

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About

Deriving general conditions and mechanisms for division of labor using the cell-based simulator `gro`

Deriving general conditions and mechanisms for division of labor using the cell-based simulator `gro`