Morphogenesis and histogenesis of the connecting tubule in the rat kidney

Neiss, Wolfram F.

doi:10.1007/bf00304585

Cited by 38 publications

(13 citation statements)

References 19 publications

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“…pelvis enlarges markedly and the number of medullary collecting ducts increases strikingly, with a corresponding reduction in nephric mesenchyme (27). During these later stages of rat pregnancy, the PRLR is expressed prominently in the perirenal and nephric mesenchyme and in medullary collecting ducts and renal tubules.…”

Section: Resultsmentioning

confidence: 98%

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.

et al. 1997

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To explore potential roles for lactogenic hormones in human fetal development, we examined the distribution and ontogenesis of expression of prolactin receptors (PRLRs) in human fetal tissues at 7.5-14 wk of gestation and in tissues of the embryonic and fetal rat on days e12.5-e20.5. Histochemical analysis of PRLR immunoreactivity in the human fetus and fetal rat revealed novel and unexpected patterns of receptor expression. Most remarkable was the appearance in early fetal development of intense PRLR immunoreactivity in tissues derived from embryonic mesoderm, including the periadrenal and perinephric mesenchyme, the pulmonary and duodenal mesenchyme, the cardiac and skeletal myocytes, and the mesenchymal precartilage and maturing chondrocytes of the endochondral craniofacial and long bones, vertebrae and ribs. Striking changes in the cellular distribution and magnitude of expression of PRLRs were noted in many tissues during development. In the fetal adrenal the initial mesenchymal PRLR expression is succeeded by the emergence of PRLR immunoreactivity in deeper fetal cortical cell layers. In the fetal kidney and lung, the invagination of cortical mesenchyme is accompanied by progressive PRLR immunoreactivity in bronchial and renal tubular epithelial cells. In the pancreas, the PRLR is expressed primarily in acinar cells and ducts in early gestation; in late gestation and in the postnatal period, the PRLR is expressed predominantly in pancreatic islets, co-localizing with insulin and glucagon. Finally in fetal hepatocytes, PRLR immunoreactivity increases significantly between embryonic days e52 and e96 in the human fetus and between days e16.5 and e18.5 in the fetal rat. In addition to playing important roles in reproduction, lactation, and immune function, the lactogenic hormones likely play roles in tissue differentiation and organ development early in gestation. ( J. Clin. Invest. 1997. 99:1107-1117.)

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Section: Resultsmentioning

confidence: 98%

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.

et al. 1997

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“…It has so far remained an open question as to whether the CNT is a developmental derivative of the nephrogenic blastema, or of the ureteric bud (Osathanondh and Potter 1966;Kaissling and Kriz 1979;Neiss 1982b). As a third possibility, the CNT may represent a hybrid entity, with shared properties induced by the apposed cell types.…”

Section: Hsd2 In Distal Tubulementioning

confidence: 99%

Sodium transport-related proteins in the mammalian distal nephron - distribution, ontogeny and functional aspects

Bachmann

Bostanjoglo

Schmitt

et al. 1999

Anatomy and Embryology

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The mammalian distal nephron plays a pivotal role in adjusting urinary sodium excretion. Successive portions of the renal tubule are formed to adapt to this function, and an axial heterogeneity of the distal segments has been defined. The specific transport properties of these epithelia are accomplished by the expression of proteins (cotransporters, exchangers, channels) governing the movement of ions on either cell side. Molecular cloning of these proteins has had a marked impact on the study of their localization and function in the healthy and diseased kidney. Electroneutral cation-chloride cotransporters [Na(K)CC] have been localized to the thick ascending limb and the distal convoluted tubule using specific probes. Proteins implicated in the function of aldosterone target cells, such as the epithelial Na(+) channel (ENaC), the mineralocorticoid receptor (MR) and 11beta-hydroxysteroid dehydrogenase type 2 (11HSD2), an enzyme that confers mineralocorticoid specificity, have been found in the terminal portion of the nephron and the collecting duct. A mineralocorticoid-sensitive component of thiazide-sensitive NaCl transport has been identified in the distal convoluted tubule. Analysis of the ontogeny of these proteins in the maturing kidney has provided a detailed picture of epithelial differentiation and morphological specialization of the renal tubule. The study of mutations of the proteins related with NaCl transport has led to the identification of the molecular causes of inherited human diseases associated with hypo- or hypertension, and the respective sites of an impaired ion transport could be mapped to the renal tubule.

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“…At an early stage of the nephron program, an outpouching of distal cells emerges from the RV derivative forming a close association with the ureteric epithelium that is enhanced by the absence of basement membrane in this region 11 ; however, histologic analysis has not described a patent luminal interconnection before S-shaped body stages. [17][18][19] To obtain a more comprehensive insight into these processes, we used high-resolution imaging to examine interconnection events. Throughthe analysis of apical and tight junction-associated membrane complexes, we show that a continuous lumen is established between the nephron and collecting duct at late Sshaped bodied stages.…”

mentioning

confidence: 99%

Invasion of Distal Nephron Precursors Associates with Tubular Interconnection during Nephrogenesis

Kao

Vasilyev

Miyawaki

et al. 2012

Journal of the American Society of Nephrology

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Formation of a functional renal network requires the interconnection of two epithelial tubes: the nephron, which arises from kidney mesenchyme, and the collecting system, which originates from the branching ureteric epithelium. How this connection occurs, however, is incompletely understood. Here, we used high-resolution image analysis in conjunction with genetic labeling of epithelia to visualize and characterize this process. Although the focal absence of basal lamina from renal vesicle stages ensures that both epithelial networks are closely apposed, we found that a patent luminal interconnection is not established until S-shaped body stages. Precursor cells of the distal nephron in the interconnection zone exhibit a characteristic morphology consisting of ill-defined epithelial junctional complexes but without expression of mesenchymal markers such as vimentin and Snai2. Live-cell imaging revealed that before luminal interconnection, distal cells break into the lumen of the collecting duct epithelium, suggesting that an invasive behavior is a key step in the interconnection process. Furthermore, loss of distal cell identity, which we induced by activating the Notch pathway, prevented luminal interconnection. Taken together, these data support a model in which establishing the distal identity of nephron precursor cells closest to the nascent collecting duct epithelium leads to an active cell invasion, which in turn contributes to a patent tubular interconnection between the nephron and collecting duct epithelia.

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Morphogenesis and histogenesis of the connecting tubule in the rat kidney

Cited by 38 publications

References 19 publications

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.

Sodium transport-related proteins in the mammalian distal nephron - distribution, ontogeny and functional aspects

Invasion of Distal Nephron Precursors Associates with Tubular Interconnection during Nephrogenesis

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