Morphogen signaling by Wnt/β‐catenin pathway and microenvironmental alteration in the bone marrow of agricultural pesticide exposure‐induced experimental aplastic anemia
Abstract:The etiologic link between pesticide toxicity and aplastic anemia in agricultural and agro‐industrial setting has been frequently reported in epidemiological studies conducted worldwide. Chronic pesticide toxicity causes long‐term bone marrow injury and perturbs the normal hematopoietic physiology, including survival of hematopoietic progenitor cells and bone marrow's blood cell forming ability. The purpose of this study is to understand the mechanism of pesticide toxicity‐mediated bone marrow aplasia by study… Show more
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