Morphofunctional estimation of the gastroprotective activity of the <i>Ferulopsis hystrix</i> dry extract in neurogenic ulcer

Abstract

The purpose of the research: morphofunctional estimation of the gastroprotective activity of the dry extract from the roots and rhizomes of Ferulopsis hystrix in neurogenic ulcer.Materials and methods: The studies were carried out on white Wistar rats. The neurogenic ulcer was simulated by 24-hour immobilization of the animals. The gastroprotective effect of Ferulopsis hystrix was estimated taking into account the Pauls’ index which was calculated for bleedings, erosions and strip-like ulcers as well as taking into account the morphometric indices (the depth of erosions) of the stomach mucosa. The intensity of lipid free radical oxidation processes was estimated by malonic dialdehyde content (MDA); the state of the antioxidant system was estimated by the activity of catalase, superoxide dismutase and the reduced glutathione content.Results. The Ferulopsis hystrix extract in the doses of 100 and 150 mg/kg reduces the depth of erosions by 43% and 80% respectively, thus promoting the diminishment of destructive processes in the stomach mucosa against the background of neurogenic ulcer. The Ferulopsis hystrix extract in the given doses decreased the MDA content by 37% on average; the catalase activity was twofold increased; the reduced glutathione increases 2.6 times and SOD activity — 3.8 and 2.8 times respectively.Conclusion. Ferulopsis hystrix has the gastroprotective effect in neurogenic ulcer.

Coumarins of Ferulopsis hystrix: LC–MS Profiling and Gastroprotective and Antioxidant Activities of Skimmin and Peucenidin

“…The F. hystrix extract reduces the platelet aggregation rate, increases bleeding time, prevents thrombosis, has an analgesic and antispasmodic action, stimulates motor-evacuation gastrointestinal tract activity, and it exhibits choleretic activity by increasing the rate of bile secretion, stimulating cholates via bile synthesis and excretion, as well as cholesterol and bilirubin excretion [32]. In vitro, the studied extract inhibits lipid peroxidation (stabilizing the structural and functional In animal experiments, F. hystrix root extract (in a dose of 100-300 mg/kg) has been found to have a gastroprotective effect against ethanol, steroid, neurogenic, and indomethacin gastropathy, and it can prevent damage to the gastric mucosa (according to Shay); this effect was achieved by increasing the resistance of the gastric mucosa to the action of aggressive factors, and by preventing the development of dystrophic and necrotic processes, as well as microcirculation disorders and inflammatory reactions, in the stomach walls of white rats [27][28][29][30]. The F. hystrix extract exhibits an anti-exudative effect (by reducing the exudation degree induced by carrageenan and formalin) and an anti-alterative effect (by limiting tissue damage caused by phlogogenic agents and accelerating the reparative regeneration processes) [31].…”