Morphofunctional characteristics of working cardiomyocytes in offspring of mothers with experimental type 1 diabetes in the early neonatal period

Abstract

The aim of this research was to analyze the features of morphofunctional state of left ventricular contractile cardiomyocytes of the offspring of mothers with experimental type 1 diabetes mellitus during the neonatal period. Diabetes mellitus was modeled in sexually mature female rats using streptozotocin. Specific area of myocardial stroma and parenchyma, the number of cardiomyocytes, nuclear-cytoplasmic ratio, the content of binucleated cells, as well as the content of glycogen in cardiomyocytes were determined on serial histological sections. It has been established that in the experimental rats there is a decrease in the number of cardiac muscle tissue, an increase in the cytoplasmic area of cardiomyocytes and excessive accumulation of glycogen in them. At the same time, the content of bicore cardiomyocytes significantly decreases in comparison with the control group. The results obtained allow us to conclude that experimental maternal type 1 diabetes mellitus has a negative effect on the morphofunctional formation of the contractile apparatus of the offspring heart.