Morpho-functional studies regarding the fertility prognosis of mares suffering from equine endometrosis

Lehmann, Jörg; Ellenberger, C.; Hoffmann, Christine; Bazer, Fuller W.; Klug, Jörg; Allen, William R.; Sieme, Harald; Schoon, Heinz-Adolf

doi:10.1016/j.theriogenology.2011.06.001

Cited by 56 publications

(89 citation statements)

References 24 publications

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“…al. 2009and Lehmann et al 2011. None of these studies have however demonstrated as strong a correlation to fertility as the papers by Doig et al (1981) and Kenney and Doig (1986).…”

Section: Kenney Scorementioning

confidence: 90%

Diagnostik der Endeometritis beim Pferd – Mikrobiologie, Zytologie und Histologie von Endometriumsbiopsien und Korrelation mit der Fruchtbarkeit

Nielsen¹,

Nielsen²,

Petersen³

2012

PHK

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SummaryThe objective of this study was to examine the relationship between pregnancy results and the presence of inflammation detected by PMNs (cytology or histology) and microbial growth from an endometrial biopsy. Following recovery of the endometrial biopsy a quick stained cytology slide and bacterial culture was performed. After this was done the biopsy was fixed in 4% formaldehyde. Histology was evaluated for presence of PMNs and a Kenney score was assigned to each mare using the guidelines proposed by Kenney and Doig (1986). Significant correlation was detected between bacterial growth and PMNs detected by histology (p=0.0082) and PMNs detected by histology and day 70 pregnancy rate (p= 0.0022), but no significant correlation could be determined between cytology or bacterial growth and day 70 pregnancy rate or cytology and presence of PMNs detected by histology. In a logistic regression model following factors were evaluated to determine impact on pregnancy rate at day 70: 1) Histological detection of PMNs, 2) Cytology, 3) Bacteriological culture, 4) Mare age and 5) Kenney score. The only significant factor with impact on day 70 pregnancy rate was histological detection of PMNs (p=0.003). Significant correlation between Kenney groups and pregnancy rates was found in both the 75 initially included mares and in 74 mares from the same two stud farms that were retrospectively included in the study (p=0.0069 and p <0.0001), respectively. The study suggests the use of histological detection of presence of PMNs to diagnose endometritis, due to the statistical association and strong negative impact of PMNs present within the endometrium on chances of establishing a pregnancy.Keywords: Reproduction, endometritis, cytology, microbiology, histology.

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“…al. 2009and Lehmann et al 2011. None of these studies have however demonstrated as strong a correlation to fertility as the papers by Doig et al (1981) and Kenney and Doig (1986).…”

Section: Kenney Scorementioning

confidence: 90%

Diagnostik der Endeometritis beim Pferd – Mikrobiologie, Zytologie und Histologie von Endometriumsbiopsien und Korrelation mit der Fruchtbarkeit

Nielsen¹,

Nielsen²,

Petersen³

2012

PHK

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“…It was observed that a large percentage of both barren and foaling mares show angiosclerosis; however, this does not have an impact on the degree of endometrosis (Lehmann et al 2011). …”

Section: Pathogenesismentioning

confidence: 99%

“…Based on the morphology of the periglandular stromal cells, the fibrosis can be divided into different types, which can be classified as either destructive or non-destructive, with biopsies displaying more than 75% of the fibrotic foci of one of these groups being termed "active" or "inactive" fibrosis respectively. Biopsy with approximately equal ratios of active and inactive periglandular stromal cells are termed "mixed" endometrosis (Table 1) (Lehmann et al 2011). In all of the above-mentioned types, single uterine glands and/or glandular nests may be affected by the process (Hoffmann et al 2009b).…”

Section: Types Of Endometrosismentioning

confidence: 99%

“…Potential etiological factors which may affect development of the disease are morphological and immunohistochemical changes of the endometrium, which occur in endometrosis (Table 1) (Hoffmann et al 2009b, Lehmann et al 2011). In the unaffected endometrium, cyclical and seasonal endocrine changes result in cycle-synchronous morphological alterations to epithelial and stromal cells.…”

Section: Pathogenesismentioning

confidence: 99%

“…In the unaffected endometrium, cyclical and seasonal endocrine changes result in cycle-synchronous morphological alterations to epithelial and stromal cells. With regard to the morphology of the periglandular stromal cells within the fibrotic foci of the endometrosis an active and inactive differentiation can be distinguished (Hoffmann et al 2009b, Lehmann et al 2011. However, in contrast to the unaltered stromal cells, neither seasonal nor cyclic endocrine changes seem to have a significant influence on the activity of the fibrotic stromal cells (Hoffmann et al 2009b).…”

Section: Pathogenesismentioning

confidence: 99%

See 2 more Smart Citations

Endometrosis – significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods

Buczkowska¹,

Kozdrowski²,

Nowak³

et al. 2014

Polish Journal of Veterinary Sciences

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Equine endometrosis is a multifactorial disease considered to be a one of the most important causes of equine infertility, especially in older mares. This article reviews the current knowledge of equine endometrosis: pathogenesis, diagnosis, and optional treatment. Also describes the histomorphological and immunohistochemical characterization of endometrosis as well as potential etiological factors which may influence disease progression. Unfortunately, the etiology and pathogenesis of endometrosis still remains unclear, and consequently no effective treatment has been proposed so far. Therefore future studies are needed for explanation of this disease.

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What Goes Wrong from a Mare Healthy Endometrium to Endometrosis?

Ferreira‐Dias

Rebordão

Galvão

et al. 2020

Advances in Animal Health, Medicine and Production

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Morpho-functional studies regarding the fertility prognosis of mares suffering from equine endometrosis

Cited by 56 publications

References 24 publications

Diagnostik der Endeometritis beim Pferd – Mikrobiologie, Zytologie und Histologie von Endometriumsbiopsien und Korrelation mit der Fruchtbarkeit

Diagnostik der Endeometritis beim Pferd – Mikrobiologie, Zytologie und Histologie von Endometriumsbiopsien und Korrelation mit der Fruchtbarkeit

Endometrosis – significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods

What Goes Wrong from a Mare Healthy Endometrium to Endometrosis?

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