Morphine is protective against doxorubicin-induced cardiotoxicity in rat

Babaeikelishomi, Rohollah; Ejtemaee-Mehr, Shahram; Tavangar, Seyed Mohammad; Rahimian, Reza; Mobarakeh, Jalal Izadi; Dehpour, Ahmad Reza

doi:10.1016/j.tox.2007.09.026

Cited by 67 publications

(40 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A large number of animals were used in the DOX treated groups (n = 10) than control groups (n=8) due to the high mortality that (50%) observed in the DOX groups in the pilot study. This mortality rate is consistent with other reports (Ferreria et al, 2007 andKelishomi et al, 2008). …”

Section: Animal Preparation and Study Designsupporting

confidence: 93%

Nigella sativa and Aloe vera protection against doxorubicin hepatotoxicity

Elzawahry¹,

Kholoussi²,

Raouf³

et al. 2016

J. Exper. Appl. Anim. Sci.

View full text Add to dashboard Cite

Doxorubicin (DOX) is a potent available antitumor agent; however, its clinical use is limited due to its significant toxicity to most tissues and organs. Administration of DOX induced acute hepatotoxicity manifested by significant elevation in serum and liver lipid peroxidation. The present study was designed to evaluate and confirm the protective effect of Nigella sativa (N.S), Aloe vera (A.V) and their mixture. A cumulative dose (30 mg/kg i.p.) of DOX divided into 6 equal doses administered over six weeks to male albino rats separate or combined with N.S, A.V or their mixture extract. At the end of the experiment, biochemical and histological parameters were assessed. Concerning oxidative stress and antioxidant defense system, the depleted hepatic glutathione content (GSH) of DOX-administered rats as well as glutathione peroxidase (GPx), catalase (CAT) and super oxide dismutase (SOD) activities were increased above normal levels as a result of pretreatment with N.S, A.V and their mixture. However, while elevated lipid peroxidation was noticed in DOX treated rats, pretreatment with N.S, A.V and their mixture produced a detectable decrease in the lipid peroxidation level. Histological measurements showed that DOX caused a marked rise multiple focal coagulative necrosis of hepatocytes associated with hemorrhage while rats pretreated with N.S, A.V and their mixture in combination with DOX showed no histopathological changes compared to normal control. From these data, it can be concluded that N.S, A.V and their mixture of extracts could be protective for the liver cells against DOX-induced hepatotoxicity due to their contents of polyphenolic compounds that might serve as novel adjuvant therapy with DOX.

show abstract

Section: Animal Preparation and Study Designsupporting

confidence: 93%

Nigella sativa and Aloe vera protection against doxorubicin hepatotoxicity

Elzawahry¹,

Kholoussi²,

Raouf³

et al. 2016

J. Exper. Appl. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…(2) Therefore, measurement of cardiospecific biomarkers can be a valid diagnostic tool for early identification, assessment, and monitoring of cardiotoxicity. Previous cardiotoxicity models include long term exposure to doxorubicin for [5][6][7][8][9][10][11][12] weeks. (5-7) LTMs are time consuming, and represent long-time stress for the animals, and high mortality rates have been reported.…”

Section: Introductionmentioning

confidence: 99%

A short-time model to study relevant indices of cardiotoxicity of doxorubicin in the rat

Hole

Larsen

Fossan

et al. 2013

Toxicology Mechanisms and Methods

View full text Add to dashboard Cite

“…The rats were anaesthetized with 1.50 g ⁄ kg urethane using the s.c. route. When the rats had reached the appropriate depth of anaesthesia, needle electrodes were inserted under the skin for the limb lead at position II and ECG parameters were measured [15]. The output signals of these systems were sampled at 100 Hz (RM6240 multi-channel physiological recording and processing system, Chengdu Instrument Factory, Sichuan, China).…”

Section: Electrocardiography (Ecg)mentioning

confidence: 99%

“…Pharmacodynamic study showed that PDs significantly reduced MK-801-induced hyperlocomotion in mice. The electrocardiogram (ECG) was recorded at 0,5,10,15,20, 25, 30, 45 and 60 min. in anaesthetized rats after i.v.…”

mentioning

confidence: 99%

Studies on the Acute Toxicity, Pharmacokinetics and Pharmacodynamics of Paliperidone Derivatives – Comparison to Paliperidone and Risperidone in Mice and Rats

Sun¹,

Su²,

Cheng³

et al. 2010

Basic Clin Pharma Tox

View full text Add to dashboard Cite

The objective of this study was to investigate the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives (PDs) compared with paliperidone and risperidone. The i.g. LD 50 and i.v. maximum tolerated doses of PD1, PD5 and PD6 were greater than those of paliperidone and risperidone in mice. Pharmacokinetic study showed that PDs were quickly metabolized to paliperidone to take effect in the treatment of schizophrenia in rats after i.g. administration. Only traces of the parent substances were found. Pharmacodynamic study showed that PDs significantly reduced MK-801-induced hyperlocomotion in mice. The electrocardiogram (ECG) was recorded at 0,5,10,15,20, 25, 30, 45 and 60 min. in anaesthetized rats after i.v. injection of 0.21, 0.59, 1.69 lmol ⁄ kg drugs. Heart rate reduction had a linear relation with dose after i.v. injection of PDs, paliperidone and risperidone. No significant change in the ECG parameters was found in all groups after administration of the low dose. Although the reductions in heart rate and the corrected QT interval (QTc) were observed in all drugs at the high dose, PD5 and PD6 were associated with smaller effects on the ECG parameters than other compounds, including paliperidone and risperidone. Therefore, PD5 and PD6 could be potential candidates for the treatment of schizophrenia.Risperidone, 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidin]ethyl}-6,7,8,9-tetrahydro-2-methyl-4H-pyrido-[1,2-a]py rimidine-4-one, is a serotonin 5-HT 2 and dopamine D 2 receptor antagonist and widely used in the treatment of schizophrenia as an atypical antipsychotic drug. In human beings, risperidone is mainly metabolized to 9-hydroxyrisperidone by cytochrome P450 in the liver [1]. Because of its antipsychotic activity, 9-hydroxyrisperidone has been reported under the name of paliperidone for the treatment of schizophrenia. Johnson and Johnson launched paliperidone under the trade name of Invega in the end of 2006. The poor absolute oral bioavailability (only 28%) and the high daily dose of Invega may lead to an increased risk of side effects [2]. Consequently, it is very important to search for new derivatives of paliperidone for the treatment of schizophrenia with higher oral bioavailability and lower side effects [3]. A series of paliperidone derivatives (PDs) were synthesized ( fig. 1) and their physical and chemical properties are listed in table 1.Among patients with schizophrenia, accelerated heart disease is a major cause of sudden death and the risk of dying from cardiovascular disease is two to three times higher than in the general population [4]. Numerous antipsychotic drugs are well-documented for their effects on the QT interval [5]. Prolongation of the QT interval by risperidone has also been reported in a clinical study [6]. In vitro electrophysiological studies showed that supra-therapeutic doses of risperidone induced the prolongation of ventricular repolarization in a dose-related and reverse use-dependent manner, which prolonged the terminal repolariza...

show abstract

Morphine is protective against doxorubicin-induced cardiotoxicity in rat

Cited by 67 publications

References 39 publications

Nigella sativa and Aloe vera protection against doxorubicin hepatotoxicity

Nigella sativa and Aloe vera protection against doxorubicin hepatotoxicity

A short-time model to study relevant indices of cardiotoxicity of doxorubicin in the rat

Studies on the Acute Toxicity, Pharmacokinetics and Pharmacodynamics of Paliperidone Derivatives – Comparison to Paliperidone and Risperidone in Mice and Rats

Contact Info

Product

Resources

About