Morphine injections in the taste aversion paradigm: Extent of aversions and readiness to consume sweetened morphine solutions

Gorman, Judith E.; Obaldia, Ricardo N. De; Scott, Robert C.; Reid, Larry D.

doi:10.3758/bf03326702

Cited by 15 publications

(1 citation statement)

References 8 publications

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“…The experiment used the now classical taste aversion paradigm (Garcia, Hankins, & Rusiniak, 1974;Riley & Baril, 1976). It has been shown that morphine, when used as the unconditioned stimulus, can sustain a poison aversion (LeBlanc & Cappell, 1974;Parker, Failor, & Weidman, 1973), but the resultant poison aversion is less intense than those sustained by unequivocally toxic agents (Gorman et al, 1978;Riley, Jacobs, & Lolordo, 1978). The taste aversion paradigm is theoretically sensitive to the ability of an agent to produce nausea and, combined with results indexing the possibility for an agent to elicit positive effect, can be used to determine if an agent produces negative effects or mixed affective events.…”

Section: Methodsmentioning

confidence: 99%

Affective consequences and subsequent effects on morphine self-administration of d-ala2-methionine enkephalin

et al. 1979

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Albino rats implanted with intracerebroventricular (lCV) cannulae were used to investigate the effects of ICV administration of d-alavmethionine enkephalin. Potentially positive affective consequences were assessed by observing rats' movements in an alley, one compartment of which had previously been paired with drug administration. Like morphine (10 mg/kg, intraperitoneally-IP), this enkephalin analogue (10 lAg, ICV) produced a tendency for rats to move toward the place where they had previously experienced the drug's effects. In another experiment, the same dose of d-alavmethionine enkephalin was not sufficient to produce a conditioned taste aversion, as did the lO·mg/kg IP dose of morphine. Rats with a prior history of administration of either d-ala--methionine enkephalin or systemic morphine subsequently consumed significantly more sweetened morphine solution than control animals in a voluntary oral consumption situation with tap water also available. Collectively , these results suggest that enkephalin administration may produce a positive affective state without aversive components and potentiate voluntary consumption of morphine.

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Section: Methodsmentioning

confidence: 99%

Affective consequences and subsequent effects on morphine self-administration of d-ala2-methionine enkephalin

et al. 1979

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Conditioned Taste Aversions and the Regulation of Drug-Taking Behavior

Stolerman¹

1984

Social and Medical Aspects of Drug Abuse

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Facilitation of memory processing by posttrial morphine: Possible involvement of reinforcement mechanisms?

Mondadori

Waser

1979

Psychopharmacology

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Posttrial administration of 40 mg/kg and 100 mg/kg, but not of 1 mg/kg, of morphine hydrochloride facilitates learning of a one-trial passive avoidance task in drug-naive mice. The effect does not depend on the punishing properties of the morphine injection, since in injection of LiCl (a strong punisher) fails to enhance learning in a similar way. After the establishment of tolerance by several morphone administrations, the 100 mg/kg, but not the 40 mg/kg, dose level resulted in memory facilitation. The data are discussed in connection with the hypothesis that morphine acts directly on reinforcement mechanisms by activating the opiate receptor.

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Morphine injections in the taste aversion paradigm: Extent of aversions and readiness to consume sweetened morphine solutions

Cited by 15 publications

References 8 publications

Affective consequences and subsequent effects on morphine self-administration of d-ala2-methionine enkephalin

Affective consequences and subsequent effects on morphine self-administration of d-ala2-methionine enkephalin

Conditioned Taste Aversions and the Regulation of Drug-Taking Behavior

Facilitation of memory processing by posttrial morphine: Possible involvement of reinforcement mechanisms?

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