Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors

Moura, Luciana Monteiro; Canteras, Newton S.; Sukikara, Marcia Harumi; Felício, Luciano Freitas

doi:10.1590/s0100-879x2010007500085

Cited by 22 publications

(21 citation statements)

References 27 publications

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“…All of these areas also influence nesting behavior in mammals (Slotnick and Nigrosh, 1975; Numan and Smith, 1984; Flannelly et al, 1986; Oxley and Fleming, 2000; Gonzalez-Mariscal et al, 2005; Moura et al, 2010), although amygdalar lesions have not been restricted to the MeA and have produced inconsistent results (Oxley and Fleming, 2000; Sheehan et al, 2001). In contrast, lesions of the LS consistently abolish nesting (Slotnick and Nigrosh, 1975; Flannelly et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Nesting behavior is associated with VIP expression and VIP–Fos colocalization in a network-wide manner

Kingsbury

Jan

Klatt

et al. 2015

Hormones and Behavior

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Many species, including humans, engage in a series of behaviors that are preparatory to the arrival of offspring. Such "nesting behaviors" are of obvious importance, but relevant neuroendocrine mechanisms remain little studied. We here focus on the potential roles of vasoactive intestinal polypeptide (VIP) in the performance of appetitive and consummatory nesting behaviors in male and female zebra finches (Taeniopygia guttata). Using combined immunocytochemistry for Fos and in situ hybridization for VIP, we now show that many VIP cell groups show increased transcriptional activity in response to nest building in male and female zebra finches. Particularly strong data come from the preoptic area (medial preoptic area and medial preoptic nucleus), where VIP-Fos co-expression correlates positively with three different measures of nesting behavior, as does the number of VIP-expressing cells. Remarkably, we find that VIP mRNA and/or VIP-Fos co-expression is correlated with nesting behavior in virtually every brain area that we examined, including the medial amygdala (anterior and posterior), medial bed nucleus of the stria terminalis, medial preoptic area, medial preoptic nucleus, anterior hypothalamus, ventromedial hypothalamus, periaqueductal gray complex (central gray and nucleus intercollicularis), and ventral tegmental area. Near-significant effects are also obtained in the tuberoinfundibular hypothalamus. Although most correlations are positive, negative correlations are observed for the VIP cell group of the anterior hypothalamus, a population that selectively promotes aggression, and also the periaqueductal gray complex. These data demonstrate a network-wide relationship between peptide production and social behavior that is, to our knowledge, unparalleled by other peptidergic modulators.

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Section: Discussionmentioning

confidence: 99%

Nesting behavior is associated with VIP expression and VIP–Fos colocalization in a network-wide manner

Kingsbury

Jan

Klatt

et al. 2015

Hormones and Behavior

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“…Instead, through its ascending and descending connections, the PAG is positioned to modulate a broad array of behavioral responses to a variety of stimuli and stressors—behavioral responses that involve concurrent modulation of somatic, autonomic, and neuroendocrine nervous system components (Shipley et al, 1991; Carrive, 1993; Floyd et al, 1996; Bandler and Keay, 1996; Keay and Bandler, 2001; Kirouac et al, 2004). More specifically, in addition to its indicated role in the modulation of defensive behavior, the PAG also has indicated involvement in various other interrelated functions and behaviors, including (but not limited to) nociception (Keay et al, 1994; Behbehani, 1995; Millan, 2002), reproductive (notably the lordosis reflex) (Sirinathsinghji, 1985; Hennessey et al, 1990; Lonstein and Stern, 1998; Murphy and Hoffman, 2001) and maternal (Lonstein and Stern, 1997; Sukikara et al, 2006, 2010; Moura et al, 2010) behaviors, and foraging and hunting behaviors (Comoli et al, 2003; Sukikara et al, 2006; Mota-Ortiz et al, 2009). The PAG may also directly modulate or be modulated by brain regions indicated to have a direct role in the control of ingestive behavior (Saper et al, 1976; Canteras et al, 1994; Thompson et al, 1996; Thompson and Swanson, 1998; Dong et al, 2001; Dong and Swanson, 2003, 2004; Mota-Ortiz et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems—motor, sensory, cognitive, and behavioral state—included in a basic structure–function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire.

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“…Most of the understanding of the neural circuits that mediate MB has been gathered from studies using adult animals. Recent studies have also shown an important role of the lateral periaqueductal gray (PAG) in the modulation of MB in lactating rats [35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Acute Lipopolysaccharide Switches the Selection of Maternal Behavior to Predatory Behavior in Female Rats

Mendes-Lima

Kirsten²,

Felício³

et al. 2017

Neuroimmunomodulation

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Objectives: A common problem during the postpartum period and during lactation is being affected by infection due to Gram-negative bacteria. In this situation, a sick mother needs to choose between caring for her pups or the need for survival. This study analyzed the effects of lipopolysaccharide (LPS)-induced sickness behavior on selection between maternal behavior (MB) and predatory behavior (PB) in lactating rats. To assess the LPS-induced sickness behavior, the plasma tumor necrosis factor-α (TNF-α) levels were measured. Methods: Lactating rats received 100 µg/kg LPS or saline solution on day 5 or 6 of lactation, 2 h before testing. Five pups and 5 cockroaches were introduced to the experimental cage at the same time and maternal and PB were observed for 30 min. The MB was measured by the pup contact, grouping, grooming, and kyphosis and the PB by contacting, eating, and foraging insects. General maternal activity was also observed, including exploration, self-grooming, and immobility. Immediately after the observations, blood was collected to measure the plasma TNF-α levels. Results: LPS administration reduced the time and frequency of pup contact, grouping, grooming, and kyphosis, with an increase in the latency to first pup contact and grouping. With regard to PB, the time of foraging and eating insects increased, and the latencies to first insect contact, eating insects, and foraging decreased. With regard to general maternal activity, immobility time and TNF-α levels increased in the LPS-treated group. Conclusions: LPS exposure switched MB to PB, prioritizing maternal survival. Thus, in more favorable situations, these rats may have new offspring and therefore her species would survive for long.

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Morphine infusions into the rostrolateral periaqueductal gray affect maternal behaviors

Cited by 22 publications

References 27 publications

Nesting behavior is associated with VIP expression and VIP–Fos colocalization in a network-wide manner

Nesting behavior is associated with VIP expression and VIP–Fos colocalization in a network-wide manner

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Acute Lipopolysaccharide Switches the Selection of Maternal Behavior to Predatory Behavior in Female Rats

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