“…Researchers have observed increased extraneuronal uptake of norepinephrine and increased levels of norepinephrine in the hippocampus and frontal cortex of rodents after treadmill training and wheel running (Dunn et al, 1996; Dishman, 1997). Increases in serotonin synthesis, metabolism, and release have been noted following exercise (Dunn and Dishman, 1991; Meeusen and De Meirleir, 1995; Wilson and Marsden, 1996; Chaouloff, 1997). Animal models utilizing chronic voluntary wheel running have also shown small increases in serotonergic neural activity in the dorsal raphe nucleus, an area of brain that is abundant in serotonergic neurons, during uncontrollable stress (Greenwood et al, 2003).…”